DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and Grip

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster

Alignment Length:	1249	Identity:	260/1249 - (20%)
Similarity:	399/1249 - (31%)	Gaps:	430/1249 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1546 REHESDLGTLSNHHSNISSISGINASSNIPAATLISSSIKKTSTEAATTKPAAPQIPGKMELLSS 1610
            ::.||...:.:.||             :.|..|.::..:   |.:.|.: ||..:..|    |:.
  Fly    31 QQQESHNNSFNGHH-------------HPPTDTALAPML---SVDRAMS-PAQSEDSG----LAP 74

  Fly  1611 NTGTTTTTTTATHH-LHQATTTKQLLVQDYLSYASPPTYSRLPPDGHE---FPP----------- 1660
            ..|||..|.|...: ||.|.|..:   ::.|||  ||....|.|.||.   ..|
  Fly    75 ERGTTYATITLPRNALHLAITFAE---RNDLSY--PPVVGSLNPVGHAADFLAPGDRLHQIDGIS 134

  Fly  1661 --NFSEPLIMH------SHPLKVTTELSYEIQ-------------------------------KG 1686
              ..|...:|:      |.......|:.|.:.                               :|
  Fly   135 TIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRG 199

  Fly  1687 GKDESSAPPLPKT-----GPPATVPRKVYRQDLVINVEPAPSLTRDYQRSLSGGTPRKPSDWRKD 1746
            |.|.    ||..|     ||       ||:..   .::|...|.|....||.|.|..:.....|.
  Fly   200 GADY----PLIVTHVRPHGP-------VYKTG---RIKPGDRLLRVDNVSLIGKTLAEAQQIIKC 250

  Fly  1747 E------------------------------KSEKSVRDKIAMFSSNNELDAIPPAPATAPISSS 1781
            .                              :.|:.:.||:.:...|        ..|..|.|.|
  Fly   251 GGHVSGYTNLTIEYDVSVVQSVEFSMGPLLIEIERPMNDKLGLVLCN--------YTAAVPASGS 307

  Fly  1782 FTRKPLNRSSENLLDSCS---SSSAP-SLKTR--AMSVE----NLNDVQRQYQLAKQLPQLHVAD 1836
            .:..|  .|.|.:.:|..   :|..| |:..|  |:||.    :::|...:          |.|.
  Fly   308 GSSTP--SSGEKIEESAGVFIASILPASIADRCGALSVGDQVLSIDDTMIE----------HTAF 360

  Fly  1837 S----MYSLNTATP--------TPSYASLPRRSH---GG---SYSSGVERRISFSGEGGDAANRK 1883
            |    |..|:|:|.        .|::| |.||.|   |.   |:|:...|:.|.:|.......||
  Fly   361 SPDEVMTILDTSTGRGYTQMQIMPAHA-LARRGHTTLGSPKYSFSTLESRKSSTAGRQRQRFARK 424

  Fly  1884 AAITNILE-------------------QRRRSLSKLRGLVIPER-PQLLEPILDLPEIKSQVKAA 1928
            :::.  ||                   ....||....||...|. |.||:.......|.|:..:.
  Fly   425 SSLP--LENPACGTPGSTGGSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHGAGIILSETVSG 487

  Fly  1929 SGEDSTDSGLGESHRSTVNRNCQLGAGG---AANNYRSILNTNQRRPLEQQLSQPPAKPPRTSLT 1990
            ||.....:.......|..:|:..:.||.   |.|...|:.....|:.||...|:..|    ::.|
  Fly   488 SGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAAAMRQLLEGGSSRNGA----SNGT 548

  Fly  1991 PLQPRSMMIPPPPPPLDQESDTDSVFSHTARVATPPEKFALTRTLSSETNTSIA-SSNTSTLTSG 2054
            |.....:.|....|  |.......|||           ..|.|........|:: ||:...:.|.
  Fly   549 PANWLELEIEFDMP--DAVVPASGVFS-----------VKLLRAGKCGLGLSVSGSSHGGLVISD 600

  Fly  2055 SSAGSQASCSSLGSTPAVDLTRRVLKSQVINGEAVALSSRKSILASAKCRSAKSRGQEEDNDSTD 2119
            ...||.|..|  ||..:.|:...|.:..|.:....||              .|..|:.::...:.
  Fly   601 VKMGSPAHRS--GSLRSGDILLAVDQHPVQHFNVDAL--------------LKEEGRSQNPSHSS 649

  Fly  2120 GEACSLANRRM-----KPISS---YKLQQQQIQLGKQLVV----DKLINVAAYVELTSDTDDSSR 2172
            .:..:|..:|:     .|:||   .......|.||..:.|    |..:..:|||......|..|.
  Fly   650 SDFTTLTIKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSL 714

  Fly  2173 RSDTPA----KISAMFIDEE-------RKASFKGDPNQQAKVKVEQV--KPMVLPMLLPSAKREP 2224
            :|.||.    ::.:|  |:.       |..|.....||.|......|  :..|.|         |
  Fly   715 KSRTPQPDYFRVPSM--DDASLQSVQLRSGSGSNGGNQAANSWSTGVNSRSYVAP---------P 768

  Fly  2225 LKQQTTAELREKFERSAAAQAQTQNHSPVIHKVTQKPHHE--RFSSLDSLASSSSGVSSTTQNVS 2287
            ..|..|.||.|:.:.      |.|.:          |.:|  |::|:|                .
  Fly   769 NTQSLTTELPEEEDE------QEQMY----------PGYELNRYASVD----------------C 801

  Fly  2288 TTQETATEFGSFSSLGSNQSLITAQDVQQIVEEADPPLKTPEAFIIVLQRENPESSIGITLAGGS 2352
            |......|...:.|..|:.|..:...:.||              |..::.|.....:||||||..
  Fly   802 TALPPPMENKVYGSAASSSSKSSGSSLHQI--------------IFTVRLEPKGGLLGITLAGSE 852

  Fly  2353 DYEAKEITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLKTPRPEVVLVVTRSE 2417
            |. .|.|||..::....|.|:|::..||::||::..|::|:....:.|:|:
  Fly   853 DI-TKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQ-------------- 902

  Fly  2418 SLVVKALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTG 2482
                        :||.|..|                |..||.||                  :.|
  Fly   903 ------------NLGDLVDL----------------KILRSHDL------------------ANG 921

  Fly  2483 SVSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAA 2547
            |         |....:|..|.::.|   .|..:|....|:                  ::....|
  Fly   922 S---------HLPQTQAIYAKVQRR---PRSPSANTEASK------------------ESGSGNA 956

  Fly  2548 SGGGA----------RC--VEIVKDSC--GLGFSIEGGFDSPLGNRPLIVKKVFMGGAAQKTNQV 2598
            :||||          |.  |.:.||..  ..|||:..|    |..|.:.:.::..||.|.....:
  Fly   957 NGGGAVNGNSGSGKPRVFHVTLYKDKVYDDYGFSVSDG----LYERGVFINRIRSGGPADMCGLL 1017

  Fly  2599 RNGDEILSINGAST 2612
            :..|.|:.:|...|
  Fly  1018 KPFDRIMQVNEMKT 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	24/81 (30%)
		PDZ_signaling	2553..2634	CDD:238492	17/64 (27%)
Grip	NP_572285.2	PDZ	82..147	CDD:294084	18/69 (26%)
		PDZ_signaling	183..254	CDD:238492	18/84 (21%)
		PDZ_signaling	278..375	CDD:238492	27/116 (23%)
		PDZ	496..>521	CDD:294084	5/24 (21%)
		PDZ_signaling	571..658	CDD:238492	23/113 (20%)
		PDZ_signaling	832..913	CDD:238492	29/123 (24%)
		PDZ_signaling	973..1055	CDD:238492	16/63 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900