DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbg and Zasp67

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_648358.2	Gene:	Zasp67 / 39148	FlyBaseID:	FBgn0036044	Length:	730	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	140/757 - (18%)
Similarity:	255/757 - (33%)	Gaps:	210/757 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 AEYYLNLLTESIKAGSESDDTASTISTVIDKFSVGSNYSSDSSLNGHELAKVLQPFTLLEQEFLP 304
            |:|...|....:..||.:|:....:..:|    |..|.::.:.|...|..:::
  Fly    23 ADYDYPLTVVKVTEGSIADEAGLRVEDII----VRINDTAATPLTHDEAHRLI------------ 71

  Fly   305 LEQPLGHPKLLIPGNNYENVEFKTEKVNVYENVE---LRSPETTPTPKPRVQLATV-------EP 359
                :|...:...|...||.|...|.:..:...|   .:||..|.:|.|...|:.:       .|
  Fly    72 ----MGSGSVFYFGVYRENEEDAYECLKKFPTSEGSLTKSPMPTISPSPTPSLSQLTETTNARTP 132

  Fly   360 KKRSIIPMPRKIPTPTKL--PIEVTPPRVPILEEPKTPTN-----------NKVDSP-KTPTNEL 410
            :....:|:||::...|..  .:||.   |.:|.|.:.|.:           |..|:| :.....|
  Fly   133 EPEPFVPLPRELAAATMAAPAVEVD---VDVLAECRQPMSEVHSEEKRGDVNGHDAPGQADEGGL 194

  Fly   411 KESPISATKIPKAKFSRAKTEGEIKLHLPAPKQQSPQSKSRIPIVSTPTAQ-------------K 462
            ....:....:|....|......||||           .:..|..|.:..::             :
  Fly   195 PVENLYLPDLPDRPCSALSERQEIKL-----------VEEEIAAVLSGESEVLKEHNVLGVNFYR 248

  Fly   463 TVPKPVSPTMNGTPLSSNIPRLLQKQKSETDLKLNLYRSKSKESSPRPPLQRANSAEAPERTFIP 527
            ..|||      |..:||::.|.|.::.::|.|:      |.||:.     |.:...:.|.|   |
  Fly   249 IFPKP------GVCMSSDVLRSLNEEVTKTKLE------KDKENR-----QWSTFLQRPNR---P 293

  Fly   528 VLLNGNSKSSNSLESVSSIGSSSSGNSVRSPKGPKPKPPERVQSLQKTQIPKLQALP--TTPPQQ 590
            |     .||..|||:.....::.....|:|  .|:.|.|          :|:.:..|  .|||::
  Fly   294 V-----PKSKQSLEAERRAANAYKVTIVKS--APREKSP----------MPEAKPAPKEATPPKE 341

  Fly   591 IPKLSMQTFKQSPPTPRSTPVGTPSPTSNREIRFKIQTYESKTQDEDKLPSLFDLVHSQENDKDK 655
            :.|      |:..|.|.......|.|..:          |.....:.::|:|..|..::..|:.
  Fly   342 VEK------KEEEPVPEEVVEPEPEPEKD----------EEPLPTDSEVPNLEQLPETELPDEQ- 389

  Fly   656 DRDSDSLKTHNSITALLAAAAAEAADLSRESPPPLVVGKCMKIVDDTNTTTCYTSSSSGEEDEDD 720
                                 .|.:|..:|...|.||                ..:..|..|.::
  Fly   390 ---------------------PEKSDAPKEVCEPEVV----------------IQTEPGSPDGNE 417

  Fly   721 LDASNREYICEDGEK-LGPPELINGPGPSEAYFNMFWHSNM------------LP-----TIGEV 767
                     ..||.. ..||.....|.|.::...:.....:            ||     |:..|
  Fly   418 ---------ASDGPAGATPPAEPITPVPVKSEEELALERQLADVQRQLAALSSLPSTIQSTLDAV 473

  Fly   768 EEEFSSLEPQSLTNGNLVKSEESKKLPKMEVNAGGLAQLTDDKIADHDASATRADTRDEVTTNQT 832
            .::.:.|.|      .:...::.|:||:::.|:|...|:.:......:...|..:|.|   ..:.
  Fly   474 TKQLADLLP------TIKLQQQEKQLPQIDENSGNEEQVEEGVTTATNTINTAGETED---AGKD 529

  Fly   833 QEISSSSSSSVKSQKTTTTTRVTTTKTSSSSSSSSCSSTVIPDVAFKLQPYEERDDILSEPITTI 897
            ..||.|.:..|...::.........:..:..|.|:..:.:..|         ::.|:..|.....
  Fly   530 ISISGSDNPPVGPCESNEDRCDANDREVAEISRSTDDNRLAKD---------KKKDLDQEQKQQQ 585

  Fly   898 HEERRVLSEQKTLSESRTRDALTG-EEQLVTSANSKSSSARF 938
            .:::..|||::...:.:..|.:.. ||.||...|.:.|...|
  Fly   586 QQQQEPLSEEQNFKKQKRHDVIEELEEHLVRKNNPRRSKRAF 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492
		PDZ_signaling	2553..2634	CDD:238492
Zasp67	NP_648358.2	PDZ_signaling	2..75	CDD:238492	12/71 (17%)
Zasp67	NP_648358.2	DUF4749	653..>699	CDD:292558
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900