DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and ssp6

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	922	Identity:	155/922 - (16%)
Similarity:	281/922 - (30%)	Gaps:	341/922 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   920 TGEEQLVTSANSKSSSARFKKISSNDNLLDLGDEQDMQEQPLTATITQESSLRERLECPQDNQSI 984
            |..:.:.|:|:|.:::|....||:: |...:|.        |.|...|:       |.|..:|..
  Fly     8 TSCQSIATAASSAATTAAAVSISAS-NATSVGS--------LIAAACQQ-------EQPHPHQHY 56

  Fly   985 DRGTLTLSERGKQLSEKEGLTTYTECETSEKESYLEGQQVLNGKG--GFVSQDENSDQPTYEREV 1047
            .:            |:::.|         ..:|:.:....:||.|  |.:...::.|....|.|.
  Fly    57 SQ------------SQQQHL---------YHQSHQQASHYVNGTGSLGRLKFHKSLDASDEEIEY 100

  Fly  1048 SETLTIVNDGEKQVTKKLEQNKEIAGKKGAK--LLKKTDEERRLEQEAQKLIESYQKVKKEAEKL 1110
            ::               |.::..|.|:..::  |....||:||                   .:.
  Fly   101 AQ---------------LSRSTHILGRHKSERYLASNPDEDRR-------------------RRT 131

  Fly  1111 YKLELADDDQGFDLSAFEQAEEEDKPEVSEEIKEVKDSQPVKVDIQIEEEVKTPNQVIGEVKVED 1175
            ..:|..::..||.|.::....:.|     ||::.:.....|:..............||..:..:|
  Fly   132 IIVEKKNNSYGFTLQSYGIHYKRD-----EELEMITYVDYVEYGGPAYRAGMREGDVILSINGKD 191

  Fly  1176 VNKEIKETVQ--VSQQEIKKEVKVSHQETKETFKSEEKDESNELKIVKEEVKVTHQDLREQIQE- 1237
            :.|...:|:.  :.|.:.:..:.|..::.                :.|.::.:.:..|:..:|:
  Fly   192 MEKADHKTIVEFIKQCDTRMRMVVLFEDC----------------VRKVDLHMRYIQLQSMLQQK 240

  Fly  1238 IEAVKVVH-KEVKVIKESAKVTTTTSHKQATKEVIISKEDHKNDSAL----------PAVSTTKV 1291
            :..::.|| :|.::::...|..:..:.|:|....  |..|.:..|..          ||:||..|
  Fly   241 MNELERVHLRERELLEGKWKTHSLPARKKANANT--SPSDGEGVSPTEVAGEAGFYRPALSTEDV 303

  Fly  1292 E-------------IISPP---------LEDDLGYVL---------------------------H 1307
            .             ||.||         |:....|||                           .
  Fly   304 PNIAARQHGVGGPGIIPPPAQFMLTYHYLDPTYRYVLRPTHGSSEEFVDGLGLQRSSSDHQPPAQ 368

  Fly  1308 KHIIFPQEKV---------KTAPT------------PLPKP----KPKPPVPTNKPKMPVNLTK- 1346
            ::::...|.|         .||||            |.|.|    |.|||....||:...:..|
  Fly   369 RYVLQQTESVDANSMTQPTTTAPTQYHSTTGGSVKPPAPPPRTCEKHKPPAKPPKPEKEKSSGKH 433

  Fly  1347 -------------------PKSAPPPVPSKRSELSGSGGKP------TPTQRRGSLETAQPPKPL 1386
                               .||| .|.|...|..:.....|      .|::||.........|..
  Fly   434 CHVGHSCNPCLGHFRWKSAEKSA-VPAPDNVSLDAYDLASPCCDTHCVPSRRRHRQHKEHTHKHK 497

  Fly  1387 ERIIVGVEQRDEPEKPQPIINLASVDLPNVAPNS------------------------------- 1420
            .|....||.:::..:|:        ...:.:||:
  Fly   498 HRDRERVESKEQRVRPK--------STSHASPNANGGAGSGHHHHHHHHHHSHEQQQQQQQQQQQ 554

  Fly  1421 ----KQATVETTPVVEMPPDELQFESHQLPDDGEKEKDLHQESN-------DLLSGSSS------ 1468
                :|...:..|:..:|      ..|..|........:..:|.       ||.||.:|
  Fly   555 QQQQQQQQQQQQPIQTVP------HHHHYPHQMHNPCQVQSQSGSTRSRYFDLASGLASHCSLHS 613

  Fly  1469 -----------SSVTTPITT------PILVSATSSMDSVQSVIEVVNGMPIISNQQTDDDDIDEV 1516
                       :|.||.|:|      |...:|.|...|.:|             :|:.:....:.
  Fly   614 CTSSEFATGDTASYTTSISTDTLFWDPTSETAQSRQHSTKS-------------RQSYEQQPQQQ 665

  Fly  1517 AAYDDGMHLEAEGTKDVRPVQEVTTLTLDRE--HESDLGTLSNHHS--NISSISGINASSNIPAA 1577
            .....|.|.......|......|||..:..:  :.:.:..:....|  |:::.:|.|........
  Fly   666 QPTHQGHHHHHHHQGDYHQRYHVTTTQMQPQQIYPNTIAYVQKPKSWDNLANKAGFNVGYGYLDT 730

  Fly  1578 TLISSSIK-------------------KTSTEAATTKPAAPQIPGKMELLSSNTGTTTTTTTATH 1623
            ..:..:||                   .|..:.....|...:..|::        |||||||.|
  Fly   731 VAVKPAIKMQIAQQRHSMPRRNPYGRYSTYGDVENYAPPPTEFVGEL--------TTTTTTTIT- 786

  Fly  1624 HLHQATTTKQLL 1635
                |.:|::||
  Fly   787 ----AKSTEELL 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375	4/24 (17%)
		PDZ_signaling	2331..2413	CDD:238492
		PDZ_signaling	2553..2634	CDD:238492
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	14/90 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900