DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and Fife

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_001261340.1	Gene:	Fife / 38337	FlyBaseID:	FBgn0264606	Length:	1314	Species:	Drosophila melanogaster

Alignment Length:	1618	Identity:	314/1618 - (19%)
Similarity:	467/1618 - (28%)	Gaps:	636/1618 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  1266 ATKEVIISKEDHKNDSALPAVSTTKVEIISPPLEDDLGYVLHKHIIFPQEKVKTAPTPLPKPKPK 1330
            ||.|....::.|..||...|..|..:..:...:...|..|..|               :.|..|:
  Fly    15 ATDEQTSERQQHAADSGGGASQTGALNKMKATISSSLLTVTDK---------------VNKMSPR 64

  Fly  1331 PP-VPTNKPKMPVNLTKPKSAPPPVPSKRSEL------------SGSGGKPTPTQRRGSLETAQP 1382
            |. |||:..      |......|...|::.:.            :.|||....|...|.
  Fly    65 PSLVPTDAD------TSGSYGSPSYQSQQQQQQDYGSSLNNNNNNSSGGGTATTGGGGG------ 117

  Fly  1383 PKPLERIIVGVEQRDEPEKPQPIINLASVDLPNVAPNSKQATVETTPVVEMPPDELQFESHQ--L 1445
                     |...:.||.:.   .....|.|.:..|:....|.              ||..|  .
  Fly   118 ---------GAAAKQEPGRR---AGACRVCLKSFKPDDYHKTC--------------FECQQRVC 156

  Fly  1446 PDDGEKEK-DLHQESN----DLLSGSSSSSVTTPITTPILVSATSSMDSVQSVIEVVNGMPIISN 1505
            .|.....| |.|:::.    .:.....:|.|..|            .||..|:::|
  Fly   157 EDCASYSKLDEHEDATMWRCSVCRRKMASRVCIP------------QDSTDSMLDV--------- 200

  Fly  1506 QQTDDDDIDEVAAYDDGMHLEAEGTKDVRPVQEVTTLTLDREH-ESDLGTLSNHHSNISSISGIN 1569
                                         ||.|    .|.|.| ::.||:
  Fly   201 -----------------------------PVLE----ALQRRHSDAKLGS--------------- 217

  Fly  1570 ASSNIPAATLISSSIKKTSTEAATTKPAAPQIPGKMELLSSNTGTTTTTTTATHHLHQATTTKQL 1634
                       |:.....|..||...|.:|::                   ..|......:.|:|
  Fly   218 -----------STQTLAPSNGAALAPPRSPEL-------------------RRHSDVSPASLKEL 252

  Fly  1635 LVQDYLSYASPPTYSRLPP--DGHEFPPNFSEPLI------------MHSH-------------- 1671
            ..|.....:..|:.|..||  :|.:..|.|..||.            .||:
  Fly   253 ERQLKGGRSMAPSRSNSPPRGEGPDGQPPFGAPLSRMQSRRGSRVARQHSYDDDMKTGPVGGSMG 317

  Fly  1672 -----------------PLKVTTELSYEIQKGGKDESSAPPL------PKTG---PPATVP---R 1707
                             |.....:.:|::...|..:..|.|.      |..|   ||..:|   |
  Fly   318 GGGPALGLGADGAGLGIPTMPRRKSAYDVFAPGLTQGGATPATQLQRSPGEGGIMPPIQLPGSRR 382

  Fly  1708 KVYRQDLVINVEPAPSLTRDYQRSLSGGTPRKPS------DWRKDEKSEKSVRDKIAMFSSNNEL 1766
            ..:|       .|.||  .|.|...|.|:|.|.|      |.|:..:....:.| |||..:...|
  Fly   383 PSFR-------VPHPS--EDIQNDDSPGSPDKGSPVLTVDDDRRMRRRGSQLPD-IAMLQNRGAL 437

  Fly  1767 DAIPPAPATAPISSSFTRKPLNRSSENLLDSCSSSSAPSLKTRAMSVENLNDVQRQYQLAKQLPQ 1831
            .|:||:....|: :|||       ..||.|    ..||..:| :|..|.:..|
  Fly   438 PAVPPSSIPPPM-ASFT-------GPNLED----LEAPRRQT-SMDGEAIRIV------------ 477

  Fly  1832 LHVADSMYSLNTATPTPSYASLPR---------RSH----------GGSYSSGVERR----ISFS 1873
            :|..||         .|..||..|         ::|          ||  .:|.:.|    |.::
  Fly   478 IHDVDS---------GPICASKRRIILRRDPTDKAHRTRGFGMRVVGG--KTGADGRLFAYIVWT 531

  Fly  1874 GEGGDAANRKAAITNILEQRRRSLSKLRGLVIPERPQLLEPILDLPEIKSQVKAASGEDSTDSGL 1938
            ..||      ||..|.|:|..:.| :..|:.:.:|.  .|.:..:.:....|.....|.:||.
  Fly   532 VPGG------AAEKNGLQQGDKIL-EWNGMSLIDRS--FEEVCSIMDRTGDVVELLVEHATDF-- 585

  Fly  1939 GESHRSTVNRNCQL--------GAGGAANNYRSILNTNQRRPLEQQLSQPPAKPPRTSLTPLQPR 1995
                     |.|.|        .|||.:...||     ...|:...|...|  ...|..:|..|.
  Fly   586 ---------RMCDLFDENLPPGNAGGQSGPRRS-----GDGPVGLGLIAEP--ETTTDKSPASPT 634

  Fly  1996 SMMIPPPPPPLDQE------------------------------SDTDSVFSHTARVATPPEKFA 2030
            ...:|..|..:.:|                              :..|..:.|    ...||.:|
  Fly   635 RRKLPKTPEQIAREKLVTGRVQIQVWYHAERSELVVSLMAGDDLAPRDEAYGH----GNLPEAYA 695

  Fly  2031 LTRTLS-------SETNTSIASSN---TSTLTSGSSAGSQ----------------------ASC 2063
            ..|.|.       .:|..|..:.|   .:|||.|......                      ..|
  Fly   696 KVRILPKCGDGSVQQTEVSRPTQNPIWNATLTFGHVKADTLMVRYIDIQLWDLVPHTESIFLGEC 760

  Fly  2064 SSLGSTPAVDLTRRVLKSQVI----------NGEAV----ALSSRKSILASAKCRSA-------- 2106
            |       ::|.:..|..|.|          .|.::    ::|.|.||.|.|...|.
  Fly   761 S-------IELQQAFLDDQAIWCRLEDTKGLRGISISKSPSVSPRGSIAAGAGAPSGDVTRLLRR 818

  Fly  2107 ---KSRGQEEDNDSTDGEACSL--------ANRRMKPISSYKLQQQQIQLGKQLVVDKLINVAAY 2160
               ..|...:|.||. |:..||        |..|.....|..::.:..||||..
  Fly   819 DYNMQRSNSDDVDSI-GDGTSLLHPDHAWIAGSRRGSSQSETMEVEVYQLGKDF----------- 871

  Fly  2161 VELTSDTDDSSRRSD---------------TPAKISAMFIDEERKASFKGDPNQQAK-------- 2202
                |.:...||||.               ||.  ::..:...|.:..:.||::..|
  Fly   872 ----SRSLPGSRRSSFQDAEKNRLEEDAMATPP--TSYLVGRRRSSVARRDPDEILKSLKAVRGE 930

  Fly  2203 ------VKVEQVKPM--------VLPMLLPSAKRE---PLKQQTTAELREKFERSAAAQAQTQNH 2250
                  :..||.|.|        .||. .||:::.   .|.||...:|::..:.....|...|..
  Fly   931 LGRTMSLGTEQHKRMGSRRASRVGLPS-GPSSRKSSVLDLSQQHQQQLQQLQQLQLQQQQYLQQQ 994

  Fly  2251 SPV----------------------IHKVTQKPHHERFSSLDSL--ASSSSGVSSTTQ---NVST 2288
            .|:                      ...|:|.|......:|..|  |:|:|.|:..||   .:.|
  Fly   995 LPMGVGNADTSPPSEDEDKRYRPRWKGSVSQLPPQSPKQALSRLKQAASASNVAQDTQRQGQLLT 1059

  Fly  2289 TQETATEFGSFSSLGSNQSLITAQDVQQIVEEADPPLKTPEAFIIVLQRENPESSIGITLAGGSD 2353
            |........|...||.:|              |.||..|...    |||:            ||.
  Fly  1060 TNPLQQRKSSMFQLGESQ--------------ASPPTTTTTH----LQRK------------GSM 1094

  Fly  2354 YEAK--EITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLK-------TPRPEV 2409
            |.||  |...|    .||..|                   |..::.|:..|.       :|:.:.
  Fly  1095 YVAKVTETPPH----GTPTRK-------------------GSVYQRSVVGLSVDSPGADSPQRKQ 1136

  Fly  2410 VLVVTRSESLV-VKALTKKRSSLG---SLSSLNEKPTELDYER----KRNYHKASRSLDLDLDLV 2466
            .:|.|.|.|.| :..||...||.|   ..|.::.|...|...|    |..:.|...:::::|...
  Fly  1137 SVVKTLSGSYVNICPLTGGESSYGLKLGPSQIHPKGYRLTTARYGELKMGFLKIKGNVEVELICA 1201

  Fly  2467 SNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEAR 2531
            .|...|.  ..||      |......:.:|      |.|.|.:         ..:.::..|||.
  Fly  1202 RNIVNED--CETP------PDTYVKCYIKD------GDRLRHK---------KKTRVVRHAAEP- 1242

  Fly  2532 NAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFDSPLGNRPLIVKKVFMG 2589
             .....|:.|:.|..    |...|.:|...| :||....|    ||...:.:.|:.:|
  Fly  1243 -LYRQTIKYQSSDVF----GRNIVIMVWQRC-VGFEHNQG----LGGTEVNLDKLSIG 1290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	17/90 (19%)
		PDZ_signaling	2553..2634	CDD:238492	10/37 (27%)
Fife	NP_001261340.1	FYVE_BSN_PCLO	130..187	CDD:277290	12/70 (17%)
		PDZ_signaling	491..580	CDD:238492	19/99 (19%)
		DegQ	<526..577	CDD:223343	13/59 (22%)
		C2A_RIM1alpha	651..779	CDD:175997	20/138 (14%)
		C2	1163..1304	CDD:301316	33/162 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900