DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbg and Lnx1

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_001101828.1	Gene:	Lnx1 / 360926	RGDID:	1308159	Length:	728	Species:	Rattus norvegicus

Alignment Length:	701	Identity:	147/701 - (20%)
Similarity:	245/701 - (34%)	Gaps:	199/701 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2008 QESDTDSVFSHTARVATPPEKFALTRTLSSETNTSIASSNTSTLTSGSSAGSQASCSSLGSTPAV 2072
            |:...|...|.||...:|....|.|.:|.::.......:.||::..|....:.:.......|.|.
  Rat   149 QDGCPDGCASLTATTLSPEVSAAATISLMTDEPGLDNPAYTSSVEDGEPVTNPSDTGRSNRTRAR 213

  Fly  2073 DLTRRVLKS---QVINGEAVALSSRKSILASAKCRSAKSRGQEEDNDST------------DGEA 2122
            ...|..::|   :.||....||...||  .||....|.......:||:.            |||.
  Rat   214 PFERSTMRSRSFKKINRALSALRRTKS--GSAVANHADQGRDNSENDTVPEVFPRLFHLIPDGEI 276

  Fly  2123 CSLANRRMKPISSYKLQQQQIQLGKQLVVDKLINVAAYVELTSDTDDSSRRSDTPAKISAMFIDE 2187
            .|:...|:.|..|..:   ::..|.:..:..:|....|.:.....|......|...|::.|.|..
  Rat   277 TSIKINRVDPNESLSI---RLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISN 338

  Fly  2188 ERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELREKFERSAAAQAQTQNHSP 2252
            .        |:..| |::               .|:|.:......|||:..||.:......::.|
  Rat   339 V--------PHNYA-VRL---------------LRQPCQVLRLTVLREQKFRSRSNAPAPDSYGP 379

  Fly  2253 ---VIHKVTQKPHHER-----------------FSSLDSLASSSSGVSSTTQNVSTTQETATEFG 2297
               ..|.:..|...|.                 |:.|:...:...|.......|.........||
  Rat   380 RDDSFHVILNKSSPEEQLGIKLVRRVDEPGVFIFNVLNGGVADRHGQLEENDRVLAINGHDLRFG 444

  Fly  2298 SFSSLG-------SNQSLITAQDVQQ----IVEEA------------------DPPLKTPEAFII 2333
            |..|..       ....|:.::.|:|    |.:||                  ..|..|....::
  Rat   445 SPESAAHLIQASERRVHLVVSRQVRQPSPDIFQEAGCISNGQQSPVSGERSTSSKPAATCHEKVV 509

  Fly  2334 VLQRENPESSIGITLAGGSDYEAKEITIHKILSNTPA---AKDGRLKKGDRILAVNGMSMRGLTH 2395
            .:|:: |..|:|:|:.||:.:...::.|: ::|..|.   ::|||:|.||.:|.|||:.:..::.
  Rat   510 SVQKD-PNESLGMTVGGGASHREWDLPIY-VISVEPGGVISRDGRIKTGDILLNVNGIELTEVSR 572

  Fly  2396 RESISVLK-TPRPEVVLVVTRSESLVVKALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSL 2459
            .|::::|| ||           .|:|:|||..|           |:.|:.|.
  Rat   573 TEAVAILKSTP-----------SSVVLKALEVK-----------EQETQEDC------------- 602

  Fly  2460 DLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELL 2524
                         || |...|..:|:||                         ||.:. |....|
  Rat   603 -------------SP-AALDSNHNVTPP-------------------------GDWSP-SWVMWL 627

  Fly  2525 ERAAEARNAIAAEIRAQAEDAAASGGGARCVEIV--KDSCG-LGFSIEGGFDSPLGNRPLIVKKV 2586
            |......|                     |.:::  :::.| |||.|.||::...||:|..:|.:
  Rat   628 ELPQYLYN---------------------CKDVILRRNTAGSLGFCIVGGYEEYSGNQPFFIKSI 671

  Fly  2587 FMGGAAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMKQLPLGPVKICFA 2637
            ..|..|....::|.||.:|::||.|||.|........:|:|. |.:.:..|
  Rat   672 VEGTPAYNDGRIRCGDILLAVNGRSTSGMMHACLARMLKELK-GKITLTIA 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	25/85 (29%)
		PDZ_signaling	2553..2634	CDD:238492	27/83 (33%)
Lnx1	NP_001101828.1	RING	45..81	CDD:214546
		DegQ	<260..364	CDD:223343	23/130 (18%)
		PDZ_signaling	276..360	CDD:238492	17/110 (15%)
		PDZ_signaling	384..464	CDD:238492	12/79 (15%)
		PDZ_signaling	506..589	CDD:238492	27/95 (28%)
		PDZ_signaling	637..721	CDD:238492	26/84 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900