DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbg and Lnx2

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_001101799.1	Gene:	Lnx2 / 360761	RGDID:	1308222	Length:	686	Species:	Rattus norvegicus

Alignment Length:	652	Identity:	138/652 - (21%)
Similarity:	222/652 - (34%)	Gaps:	218/652 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  2111 QEEDNDSTDGEACSLANRRMKPISSYKLQQQQIQLGKQLVVDKLINVAAYVELTSDTDDSSRRSD 2175
            ||:|       .|.|..:|:    .:||.::...|..:| :|||:.:..:   :|...|..:|.|
  Rat    80 QEKD-------FCPLDRKRL----HFKLCKKSSILVHKL-LDKLLVLCPF---SSVCQDVMQRCD 129

  Fly  2176 TPAKISAMFIDEERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELREKFERS 2240
            ..|.:.                |:               .|..|.:|..|:::.|::
  Rat   130 LEAHLK----------------NR---------------CLGASHRRVDLERRKTSQ-------- 155

  Fly  2241 AAAQAQTQNHSPVIHKVTQKPHHERFSSLDSLASSSSGVSSTTQNVST-TQETATEFGSFSSLGS 2304
            |..|.:.:..|.||......|     ...|.|.:.....:||...:.. |::...:..:|
  Rat   156 AHTQIEGETGSTVIDPPGPSP-----PETDCLGTVPGERNSTPAPLPVWTEDPGLDNPAF----- 210

  Fly  2305 NQSLITAQDVQQIVEEADPPLKTPEAFI--IVLQRENPESSIGITLAGGSDYEAKEITIHKILSN 2367
             :....|..|||       ||..||..|  |.:.|.||...:||::.||::.....|.|.::..:
  Rat   211 -EESAAADSVQQ-------PLSLPEGEITTIEIHRTNPYIQLGISIVGGNETPLINIVIQEVYRD 267

  Fly  2368 TPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLKTPRPEVVLVVTRSESL------------- 2419
            ...|:||||..||:||.||...:..::|..:.:||..|...:.|.|.|....
  Rat   268 GAIARDGRLLAGDQILQVNNCDISNVSHNYARAVLSQPCSTLHLTVLRERRFGSRANNHADGSAP 332

  Fly  2420 ---VVKALTKKRSSL-----------------------GSLSSLNEKPTELDYERKRNYHKASRS 2458
               |.:.|..||.|.                       |.|::.:.:.:..|.....|.|...:.
  Rat   333 RDEVFQVLLHKRDSAEQLGIKLVRRTDEPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKQG 397

  Fly  2459 LDLDLDLVSNEAGE-------SPVATTPSTGS----------VSPP---QPASLHD--------- 2494
            .......:...:||       .|....||.||          ..||   :|:|..|
  Rat   398 TPELAAHIIQASGERVNLTIARPGKPQPSNGSREAGAHSSNHAQPPSHSRPSSHKDLTRCVTCQE 462

  Fly  2495 ----------EDAEATIAGIRARR---------------------QLSRGDA---------AKLS 2519
                      |....|:||.|..:                     ::.|||.         ..||
  Rat   463 KHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLS 527

  Fly  2520 TSE---LLERAAEA----RNAIAAEIRAQAEDAAASGGGA------------------------- 2552
            .||   :|:.:|.:    ..|:..:|..:|..|.....||
  Rat   528 HSEAVAMLKASAASPAVILKALEVQIAEEAAQATEEQPGAFSENEYDASWSPSWVMWLGLPSALH 592

  Fly  2553 RCVEIVKDSCGL---GFSIEGGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSR 2614
            .|.:||.....|   ||||.||::....|:|..:|.:.:|..|....:::.||.|:::||.||..
  Rat   593 SCHDIVLRRSYLGSWGFSIVGGYEENHSNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVG 657

  Fly  2615 MT 2616
            |:
  Rat   658 MS 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	27/83 (33%)
		PDZ_signaling	2553..2634	CDD:238492	23/67 (34%)
Lnx2	NP_001101799.1	mRING-HC-C3HC3D_LNX2	46..90	CDD:319694	5/16 (31%)
		PDZ	229..315	CDD:214570	28/85 (33%)
		PDZ	335..421	CDD:214570	12/85 (14%)
		PDZ_signaling	462..538	CDD:238492	13/75 (17%)
		PDZ_signaling	595..679	CDD:238492	22/65 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900