DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and Ush1c

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	XP_006229284.1	Gene:	Ush1c / 308596	RGDID:	1303329	Length:	910	Species:	Rattus norvegicus

Alignment Length:	767	Identity:	159/767 - (20%)
Similarity:	274/767 - (35%)	Gaps:	179/767 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   920 TGEEQLVTSANSKSSSARFKKISSNDNLLDL--GDEQDMQEQPLTATITQESSLRERLECPQDNQ 982
            |.||.:......|:.|.:.:.|    .|:.:  ..|:.::.|.:...:::...:|..|..|
  Rat   146 THEEVINLIRTKKTVSIKVRHI----GLIPVKSSPEEPLKWQYVDQFVSESGGVRGGLSSP---- 202

  Fly   983 SIDRGTLTLSERGKQLS--EKEGLTTYTECETSEKESYLEGQQVLNGKGGFVSQD---ENSDQPT 1042
                |..|..|:...:|  ...||    .|..|.......|..|.|.|.|.:|.:   |..||..
  Rat   203 ----GNRTTKEKKVFISLVGSRGL----GCSISSGPIQKPGIFVSNVKPGSLSAEVGLETGDQIV 259

  Fly  1043 YEREVSETLTIVNDGEKQVTKKLEQNKEI-------AGKKGAKLLKKTDEER------------- 1087
               ||: .:...|...|:....|:.::.:       ||::    |..||.||
  Rat   260 ---EVN-GIDFTNLDHKEAVNVLKSSRSLTISIVAGAGRE----LFMTDRERLEEARQHELQRQE 316

  Fly  1088 -----RLEQEAQKLIESYQKVKKEAEKLYKLELADDDQGFDLSAFEQAEEEDKPEVSEEIKEVKD 1147
                 ||..|:.|:::..|:::::..|....:.|::::.:         .::..::|||  |.|.
  Rat   317 LLMQKRLAMESNKILQEQQEMERQRRKEIAQKAAEENERY---------RKEMEQISEE--EEKF 370

  Fly  1148 SQPVKVDIQIEEEVKTPNQVIGEV-------------------KVEDVNKEIKETVQVSQQEIKK 1193
            .:..:.|...:|::..|..:..||                   |...:.|:.||         ||
  Rat   371 KKQWEEDWGSKEQLILPKTITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKAKE---------KK 426

  Fly  1194 EVKVSHQETKETFKSEEKDESNELKIVKEEVKVTHQDLREQIQEIEAVKVVHKEVKVIKESAKVT 1258
            :.|   .::.:..:..:|:...|.|:.||:.::..::.:.:|..: |.:|...|.:.::||.|..
  Rat   427 KAK---YDSLQDLRKNKKELEFEQKLYKEKEEMLEKEKQLKINRL-AQEVSETEREDLEESEKTQ 487

  Fly  1259 TTTSHKQATK-EVIISKEDHKNDSAL-PAVSTTKVEIISPPLEDDLGYVLHKH-----------I 1310
            ........|: :.|.|.|:...:... |......|..:.|||....|.: |.|           .
  Rat   488 YWVERLCQTRLQQISSAENEITEMTTGPPPPPPSVSPLVPPLRRFAGGI-HLHTTDLDDIPLDMF 551

  Fly  1311 IFPQEKVKTAPTPLPKPKPKPPVPTNKP-KMPVNLTKPKS-------------APPPVPSKRSEL 1361
            .:|.:    .|:.|| ..|.|| |:|.| |:|.....|.|             .|||:|.
  Rat   552 YYPPK----TPSALP-VMPHPP-PSNPPSKVPAPPVLPSSDHMSSSSSPWVQHTPPPIPI----- 605

  Fly  1362 SGSGGKPTPTQRRGSLETAQP-PKPLERIIVGVEQR-DEPEKPQPIINLASVDLPNVAPNSKQAT 1424
                 .|.|:.....|...:| |..||.::.....| .:|..|       :.|. ....:|.:.|
  Rat   606 -----PPPPSIPTQDLTPTRPLPSALEEVLGNHPFRTGDPGHP-------ATDW-EANTHSGKPT 657

  Fly  1425 VETTPVVEMPPDELQFESHQLPDDG------EKEKDLHQESNDLLSGSSSSSV-TTPITTPILVS 1482
            ...||....||....|.....|..|      .|...:|||.|.:...:..|.| ...:...::|.
  Rat   658 SSPTPERSFPPAPKTFCPSPQPPRGPGVSTISKPVMVHQEHNFVYRPAVKSEVLPQEMLKRMVVY 722

  Fly  1483 ATSSMDSVQSVIEVVNGMPIISNQQTDDDDIDEVAAYDDG-MHLEAEGTKDVRPVQEVTTLTLDR 1546
            .|:.....:...|..:...:.|.:|....|:..:....:| :.|..||..| .||.:|....:
  Rat   723 QTAFRQDFRKYEEGFDPYSMFSPEQIAGKDVRLLRIKKEGSLDLALEGGVD-SPVGKVVVSAV-- 784

  Fly  1547 EHESDLGTLSNHHSNI---SSISGINASSNIPAATLISSSIKKTSTEAATTK 1595
             :|   |..:..|..:   ..|..||..        |.:.......|||..|
  Rat   785 -YE---GGAAERHGGVVKGDEIMAINGK--------IVTDYTLAEAEAALQK 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375	8/42 (19%)
		PDZ_signaling	2331..2413	CDD:238492
		PDZ_signaling	2553..2634	CDD:238492
Ush1c	XP_006229284.1	harmonin_N	2..80	CDD:259819
		PDZ_signaling	85..165	CDD:238492	5/18 (28%)
		PDZ_signaling	209..289	CDD:238492	20/87 (23%)
		Cgr1	<316..>358	CDD:281823	7/50 (14%)
		PDZ_signaling	751..838	CDD:238492	20/89 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900