DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bbg and Pard3b

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_001178737.1	Gene:	Pard3b / 301455	RGDID:	1584992	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	659	Identity:	131/659 - (19%)
Similarity:	199/659 - (30%)	Gaps:	275/659 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly  1990 TPLQPRSMMIPPPPPPLDQESDTDSVFSHTARVATPPEKFALTRTLSSETNTSIASSNTSTLTSG 2054
            |||..|....|.|.|..|.:..|          |:|..:......|.|..|.    .|...:.
  Rat   133 TPLLVRRSSDPAPGPHADAQPST----------ASPSGQSLKPVVLDSAQNL----ENRDVMN-- 181

  Fly  2055 SSAGSQASCSSLGST--PAVDLTRRVLKSQVINGEA-----------VALSSR------KSILAS 2100
               |.|.....|..|  ...|:||.|    .|:||.           .:||.|      :.|..:
  Rat   182 ---GEQTGLLMLHKTKNELSDMTRAV----EISGEGDPLGIHVVPFFSSLSGRILGLFIRGIEEN 239

  Fly  2101 AKCRSAKSRGQEEDN------------DSTDGEACSLANRRMKP---ISSYKLQQQQIQLGKQLV 2150
            ::|   |..|..::|            |.|..:|..:..:.||.   :....|.|.:.|..|
  Rat   240 SRC---KQEGLFQENECIVKINNVELLDKTFAQAQDVFRQAMKSPSVVLHVLLPQNREQYEK--- 298

  Fly  2151 VDKLINVAAYVELTSDTDDSSRRSDTPAKISAMFIDEERKASFKGDPNQQAKVKVEQVKPMVLPM 2215
                 :|...:.:..:.|.:||.                    |..|..:.|..::.|.|
  Rat   299 -----SVIGQLNIFGNNDSASRT--------------------KAPPPTRGKAGLKAVNP----- 333

  Fly  2216 LLPSAKREPLKQQTTAELREKFERSAAAQAQTQNHSPVIHKVTQKPHHERFSSLDSLASSSSGVS 2280
                         |.|...|. |.|.:.|   |:.||.:.::.:||.....|.|....|..:
  Rat   334 -------------TRANSPEG-EESPSPQ---QSKSPRVPRLGRKPSSPSLSPLMGFGSKKN--- 378

  Fly  2281 STTQNVSTTQETATEFGSFSSLGSNQSLITAQDVQQIVEEADPPLKTPE--AFIIVLQRENPESS 2343
                                          |:.::..::      |.||  .|.:|.:    :||
  Rat   379 ------------------------------AKKIKIDLK------KGPEGLGFTVVTR----DSS 403

  Fly  2344 IGITLAGGSDYEAKEITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLK-TPRP 2407
            |         :....|.:..||....|.|||||:.|||||.|||..:.|.|..|.:::|: |.:.
  Rat   404 I---------HGPGPIFVKNILPKGAAVKDGRLQSGDRILEVNGRDVTGRTQEELVAMLRSTKQG 459

  Fly  2408 EVV-LVVTRSESLVVKALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAG 2471
            |.| ||:.|.|              ||.     .|.||..|..........|..|.|::..|::|
  Rat   460 ETVSLVIARQE--------------GSF-----LPRELKGEPDCYALSLESSEQLTLEIPLNDSG 505

  Fly  2472 ESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAA 2536

  Rat   506 ----------------------------------------------------------------- 505

  Fly  2537 EIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFDSPLG-NRPLIVKKVFMGGAAQKTNQVRN 2600
                                    |.|||.|::|......| :..:.:|.:..||||.|..::|.
  Rat   506 ------------------------SAGLGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRM 546

  Fly  2601 GDEILSING 2609
            .|:::::||
  Rat   547 NDQLIAVNG 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	30/83 (36%)
		PDZ_signaling	2553..2634	CDD:238492	17/58 (29%)
Pard3b	NP_001178737.1	DUF3534	1..143	CDD:288873	4/9 (44%)
		PDZ_signaling	201..288	CDD:238492	19/93 (20%)
		PDZ	380..469	CDD:214570	34/107 (32%)
		PDZ_signaling	501..589	CDD:238492	19/144 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900