DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and GRIP1

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	XP_016874587.1	Gene:	GRIP1 / 23426	HGNCID:	18708	Length:	1188	Species:	Homo sapiens

Alignment Length:	976	Identity:	186/976 - (19%)
Similarity:	315/976 - (32%)	Gaps:	349/976 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1760 FSSNNELDAI---------PPAPATAPISSSFTRKPLNRSSENLLDSCSSSSAPSLKTRAMS--V 1813
            ||::..|||.         ||        ...|:..|::|....|...:|..:|..|:.:.:  .
Human    52 FSASEALDAYIDDFHLNYEPP--------DIDTKVNLDQSPLEFLAKSNSDESPYTKSASQTKPP 108

  Fly  1814 ENLNDVQRQYQLAKQLPQLHVADSMYSLNTATPTPSYASLPRRSHGGSYSSGVER----RISFSG 1874
            :....|:||     .:|:.....::..|.....|         :.|.:.|.|:::    |:|...
Human   109 DGALAVRRQ-----SIPEEFKGSTVVELMKKEGT---------TLGLTVSGGIDKDGKPRVSNLR 159

  Fly  1875 EGGDAANRK--------AAITNILEQRRRSLSKLR-----GLV--IPERPQLLEPILDLPEIKSQ 1924
            :||.||...        .|:..|      :|:|.|     .|:  :.|| .:||...:||.:..|
Human   160 QGGIAARSDQLDVGDYIKAVNGI------NLAKFRHDEIISLLKNVGER-VVLEVEYELPPVSVQ 217

  Fly  1925 VKAASGEDSTDSGLGESHRSTVNRNCQLGAGGAANNYRSIL------NTNQRRPLEQQLSQPPAK 1983
                             ..|.:.|..::......|.:..::      :.|:.||:
Human   218 -----------------GSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPV---------- 255

  Fly  1984 PPRTSLTPLQPRSMMIPPPPPPLDQESDTD------SVFSHTARVATPPEKFALTRTLSSETNTS 2042
                .:|.::|..        |.|:|....      ||........|..|..::.:....|. ..
Human   256 ----VITCVRPGG--------PADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEA-AL 307

  Fly  2043 IASSNTSTLTSGSSAGSQASCSSLGSTPAVDLTRRVLKSQVINGEAVALSSRKSILASAKCRSAK 2107
            :...:.|.:.|.::| |......:..||...|...:..|...|.:.:.:...||...:.:|.:..
Human   308 LIEYDVSVMDSVATA-SGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALH 371

  Fly  2108 SRGQEEDNDSTDGEACSLANRRMKPISSYKLQQQQIQLGKQLVVDKLINVAAYVELTSDTDDSSR 2172
            ........|.|..|.|:||..                                .:..::|.|
Human   372 VGDHILSIDGTSMEYCTLAEA--------------------------------TQFLANTTD--- 401

  Fly  2173 RSDTPAKISAMFIDEERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELR--- 2234
                                              |||..:||           ..||...|:
Human   402 ----------------------------------QVKLEILP-----------HHQTRLALKGPD 421

  Fly  2235 ----EKFERSAAAQAQTQNHSPV---IHKVTQKPHHERFSSL-----------DSLASSS----- 2276
                ::.:|.....:...|||.:   .|..|..|.|.|..:|           .:|.|||
Human   422 HVKIQRSDRQLTWDSWASNHSSLHTNHHYNTYHPDHCRVPALTFPKAPPPNSPPALVSSSFSPTS 486

  Fly  2277 -SGVSSTTQNVST-------TQETAT---------EFGSFSSLGSNQSLITAQDVQQIVEEADPP 2324
             |..|.::.|:.|       |....|         :|.|..||.|:...:..|.|.....|
Human   487 MSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTE---- 547

  Fly  2325 LKTPEAFIIVLQRENPESSIGITLAGGSDYEAKEIT----IHKILSNTPAAKDGRLKKGDRILAV 2385
                     |:...:|.:..||.|. ||.:..:.::    |..|.:::||.:.|.|:.|||::|:
Human   548 ---------VVLTADPVTGFGIQLQ-GSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAI 602

  Fly  2386 NGMSMRGLTHRESISVLKTPRPEVVLVVTRSESLVVKALTKKRSSLGSLSSLNEKPTELDYERKR 2450
            ||:.....|..|:..:|:.                              ||:..|.|
Human   603 NGIPTEDSTFEEASQLLRD------------------------------SSITSKVT-------- 629

  Fly  2451 NYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARR------- 2508
                    |:::.|:     .||.:   ||:|:.....|.. |:.:...||:...:|:
Human   630 --------LEIEFDV-----AESVI---PSSGTFHVKLPKK-HNVELGITISSPSSRKPGDPLVI 677

  Fly  2509 -QLSRGDAA-KLSTSELLERAAEARN--------AIAAEIRAQAEDAA---------------AS 2548
             .:.:|..| :..|.||.::.....|        ..|.:|..|.||..               :|
Human   678 SDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESS 742

  Fly  2549 GGGARCVEIVKDSCGLGFSIEG---GFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGA 2610
            |.....||:.:....||.:|.|   .||      |:|:..:..||.|::|..:..||.||:||.:
Human   743 GAIIYTVELKRYGGPLGITISGTEEPFD------PIIISSLTKGGLAERTGAIHIGDRILAINSS 801

  Fly  2611 S 2611
            |
Human   802 S 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	22/85 (26%)
		PDZ_signaling	2553..2634	CDD:238492	21/62 (34%)
GRIP1	XP_016874587.1	PDZ_signaling	128..208	CDD:238492	21/95 (22%)
		PDZ_signaling	227..310	CDD:238492	14/105 (13%)
		PDZ_signaling	325..408	CDD:238492	19/151 (13%)
		PDZ_signaling	545..633	CDD:238492	28/147 (19%)
		PDZ_signaling	646..730	CDD:238492	16/84 (19%)
		PDZ_signaling	746..827	CDD:238492	21/63 (33%)
		PDZ_signaling	1062..1142	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810