DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bbg and PDZD2

DIOPT Version :9

Sequence 1:NP_001246755.1 Gene:bbg / 39583 FlyBaseID:FBgn0087007 Length:2637 Species:Drosophila melanogaster
Sequence 2:XP_005248326.1 Gene:PDZD2 / 23037 HGNCID:18486 Length:2873 Species:Homo sapiens


Alignment Length:2839 Identity:577/2839 - (20%)
Similarity:934/2839 - (32%) Gaps:959/2839 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 DVGSGSS-----PTMEEQI-ENVTVFRLPGERLGFGLKFQGGTRSTELVQK---LYIQSCAADSP 129
            |.||.||     |..:::| ..||:.:.|  |:|.|:    |.....|...   :||.|.|..|.
Human   707 DEGSSSSLGRKTPGPKDRIVMEVTLNKEP--RVGLGI----GACCLALENSPPGIYIHSLAPGSV 765

  Fly   130 ASKVSTSWGNLREGDEIVSIDGRDVRE--LTRIDCVRGLKDNVAIKLVVRNGHGQKPPSEEDPQQ 192
            |...|    ||..||:|:.::..:||.  |:::..:........::||:    |:.|..:...|:
Human   766 AKMES----NLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVI----GRHPNPKVSEQE 822

  Fly   193 QEHL--------SITLNAQPPPPPPVPPRKLVRRQNSKENQAQLLIEKPLTPPPDAEYYLN---- 245
            .:.:        |...|:.|....|:....|.::.:       |:.|..|     ::|:.:    
Human   823 MDEVIARSTYQESKEANSSPGLGTPLKSPSLAKKDS-------LISESEL-----SQYFAHDVPG 875

  Fly   246 LLTESIKAGSESDDTASTISTVIDKFSVGSNYSSDS-----------SLNGHELAKVL-QPFTLL 298
            .|::.:.||||.:|...:..:..::.|:..:.|:..           :|..|..:.:. :..|:.
Human   876 PLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPGKPRANSLVTLGSHRASGLFHKQVTVA 940

  Fly   299 EQEFLPLEQPLGHPKLLIPGNNYENVEFKTEKVNVYENVELRSPETTPTPKPRVQLATVEPKKRS 363
            .|..||     |.|:.|      .|...:..||..|:..:....|..             .::..
Human   941 RQASLP-----GSPQAL------RNPLLRQRKVGCYDANDASDEEEF-------------DREGD 981

  Fly   364 IIPMPRKIPTPTKLPIEVTPPRVPILEEPKTPTNNKVDSP-KTPTNELKESPISAT------KIP 421
            .|.:|..:|.|.:...|..|.||.|........:|:.:.| ||..::...:|:..:      .||
Human   982 CISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLEESIP 1046

  Fly   422 KAKFSRAKTEGEIKLHLPAPKQQSPQS---KSRIPIVSTPTAQKTVPKPV-SPTMNGTPLSSNIP 482
            :.....|.....:.....||| .||.|   |......|.|..:.||.... |||..|:|.|    
Human  1047 EGMVDAASYAANLTDSAEAPK-GSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSPSS---- 1106

  Fly   483 RLLQKQKSETDLKLNLYRSKSKESSPRP-----PLQRANSAEAPERTFIPVLLNGNSKSSNSLES 542
               .:||||           ...|..||     |..:.:.|||.......|.|.|.:.....|:|
Human  1107 ---PQQKSE-----------GLGSRHRPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDS 1157

  Fly   543 ---VSSIGSSSSGNSVRSPKGPKPKPPERVQSLQK---------------TQIPKLQALPTTPPQ 589
               .:|:..:.:|   ..|.|...|     :||.|               :.:..|.|...|  :
Human  1158 RVQATSVKVTVAG---FQPGGAVEK-----ESLGKLTTGDACVSTSCELASALSHLDASHLT--E 1212

  Fly   590 QIPKLSMQTFKQ-------------SP-------PTPRSTPVGT--------PS-PTSNREIRFK 625
            .:||.:.:..:|             ||       |.|..|.|.|        || |.|.|..:.|
Human  1213 NLPKAASELGQQPMTELDSSSDLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVTKCK 1277

  Fly   626 IQT-----YESKTQDEDKLPSLFDLVHSQENDKDKDRDSDSLKT-HNS--ITALLAAA-AAE--- 678
            .::     :|......:|.        :...|..|.|.:....| ||:  :.||..|. .||   
Human  1278 ARSPVRLPHEGSPSPGEKA--------AAPPDYSKTRSASETSTPHNTRRVAALRGAGPGAEGMT 1334

  Fly   679 -----------AADLSRESPPPLVVGKCMKIVDDTNTTTCYTSSSSGEEDEDDLDASNREYICED 732
                       .:...|:..|    |...|.::   .|..:...||.|                 
Human  1335 PAGAVLPGDPLTSQEQRQGAP----GNHSKALE---MTGIHAPESSQE----------------- 1375

  Fly   733 GEKLGPPELINGP------GPSEAYFNMFWHSNMLPTIGEVEEEFSSLEPQSLTNGNLVKSEESK 791
                  |.|:.|.      .|..:.       :|||:....:|....:.......|       |:
Human  1376 ------PSLLEGADSVSSRAPQASL-------SMLPSTDNTKEACGHVSGHCCPGG-------SR 1420

  Fly   792 KLPKMEVNAGGLAQLTDDKIADHDASATRADTRDEVTTNQTQEISSSSSSSVKSQKTTTTTRVTT 856
            :.|..::         |..|.:.||||.|:      .::||.: |.|...|.:..          
Human  1421 ESPVTDI---------DSFIKELDASAARS------PSSQTGD-SGSQEGSAQGH---------- 1459

  Fly   857 TKTSSSSSSSSCSSTVIPDVAFKLQPYEERDDILSEPITTIHEERRVLSE-----QKTLSESRTR 916
             ..:.:...|||.:..:|            ....|.|       ||..:.     .:..|:....
Human  1460 -PPAGAGGGSSCRAEPVP------------GGQTSSP-------RRAWAAGAPAYPQWASQPSVL 1504

  Fly   917 DALTGEEQLVTSANSKSSSAR-FKKISSNDNLLD-------------LGDEQDMQEQPLTATITQ 967
            |::..::....:.|..|:.:| |.....:...|.             .||.:|....|.:.|...
Human  1505 DSINPDKHFTVNKNFLSNYSRNFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAP 1569

  Fly   968 ESSLRERLECPQDNQSIDRGTLTLSERGKQLSEKEGL-------------------TTYTECETS 1013
            .:|.|       |..|..|..::|.:.....||:|.:                   |....|..|
Human  1570 RASAR-------DGWSPPRSRVSLHKEDPSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPAS 1627

  Fly  1014 EK----------ESYLEGQQVLNGKGGFVSQDENSDQPTYEREVS----ETLTIVNDGEKQVTKK 1064
            .|          ||....::......|..:...:|.||:...|:|    ||...::..:......
Human  1628 AKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLEMSSQEHETHADISTSQNHRPSC 1692

  Fly  1065 LEQNKEIAGKKGAKLLKKTDEERRLEQEAQ-----KLIESYQKVKKEAEKLYKLELADDD----- 1119
            .|:..|:.....|.      |...|.:.|:     .:|.|...:....|.    :|.||:     
Human  1693 AEETTEVTSASSAM------ENSPLSKVARHFHSPPIILSSPNMVNGLEH----DLLDDETLNQY 1747

  Fly  1120 -----QGFDLSAFEQAEEEDKPEVSEEIKE---VKDSQPVKVDIQIEEEVKTPNQVIGE---VKV 1173
                 ....||:|    ..|.|:..|.:.|   :.:||      .:::.::.|..:...   ...
Human  1748 ETSINAAASLSSF----SVDVPKNGESVLENLHISESQ------DLDDLLQKPKMIARRPIMAWF 1802

  Fly  1174 EDVNKEIKET---------------------VQVSQQEIKKEVKVSHQETKETFKSEEKDESNEL 1217
            :::||..:.|                     :|:.....||.|.|.|...:.....|.||.|   
Human  1803 KEINKHNQGTHLRSKTEKEQPLMPARSPDSKIQMVSSSQKKGVTVPHSPPQPKTNLENKDLS--- 1864

  Fly  1218 KIVKEEVKVTHQDLREQIQEIEAVKVVHKEVKVIKESAKVTTTTSHKQATKEVIISKEDHKNDSA 1282
            |....|:.:|:....:...:::.:.        :|..|||   .|...|...|.....||:.   
Human  1865 KKSPAEMLLTNGQKAKCGPKLKRLS--------LKGKAKV---NSEAPAANAVKAGGTDHRK--- 1915

  Fly  1283 LPAVS-TTKVEIISPPLEDDLGYVLHKHIIFPQEKVKTAP-TPLPKPKPKPPVPTNKPKMPV--- 1342
             |.:| .|..:.:|..:...|....|:.   |......|| :|....:.|||:.|:.|..|.   
Human  1916 -PLISPQTSHKTLSKAVSQRLHVADHED---PDRNTTAAPRSPQCVLESKPPLATSGPLKPSVSD 1976

  Fly  1343 ----NLTKPKSAPPPVPSK-------RSELSGSGGKPTPTQRRGSLETAQPPKPLERIIVGVEQR 1396
                ....|.::|.|||.:       .:.||    :|.    ||...|.:.||          .|
Human  1977 TSIRTFVSPLTSPKPVPEQGMWSRFHMAVLS----EPD----RGCPTTPKSPK----------CR 2023

  Fly  1397 DEPEKPQ----PIINLASVDLPNVAPNSKQATVETTPVVEMPPDELQFESHQLPDDGEK----EK 1453
            .|...|:    |:...||.:..:||.|.:              .|.:..||...|..:.    ||
Human  2024 AEGRAPRADSGPVSPAASRNGMSVAGNRQ--------------SEPRLASHVAADTAQPRPTGEK 2074

  Fly  1454 DLHQESNDLLSGSSSSSVTTPITTPILVSATSSMDSVQSVIEVVNGMPIISNQQTDDDDIDEVAA 1518
            ..:..::|.|..::...:       :.:||       ::|.|.|.|     |:..:.|......|
Human  2075 GGNIMASDRLERTNQLKI-------VEISA-------EAVSETVCG-----NKPAESDRRGGCLA 2120

  Fly  1519 YDDGMHLEAEGTKDVRPVQEVTTLTLDREHESDLGTLSNHHSNISSISGINASSNIPAATLISSS 1583
              .|...|....:..|.|.|.:|     .|.|   :|.:|.|....    ..|.:...|.|.|||
Human  2121 --QGNCQEKSEIRLYRQVAESST-----SHPS---SLPSHASQAEQ----EMSRSFSMAKLASSS 2171

  Fly  1584 IKKTSTEAATTKPAAPQIPGKMELLSSNTGTTTTT----TTATHHLH----QATTTKQLLVQDYL 1640
               :|.:.|..|....|  ||..|:|.:.|....:    .:...||:    .||.|         
Human  2172 ---SSLQTAIRKAEYSQ--GKSSLMSDSRGVPRNSIPGGPSGEDHLYFTPRPATRT--------- 2222

  Fly  1641 SYASPPTY-SRLPPDGHEFPPNFSEPLIMHSHPLKVTTELSYEIQKGGKDESSAPPLPKTGPPAT 1704
             |:.|..: |....:||  ||          |.|             |:...|..|:..      
Human  2223 -YSMPAQFSSHFGREGH--PP----------HSL-------------GRSRDSQVPVTS------ 2255

  Fly  1705 VPRKVYRQDLVINVEPAPSLTRDYQRSLSGGTPRKPSDWRKDEKSEKSVRDKIAMFSSNNELDAI 1769
                        :|.|....:|....||:.|         :...|.|.:.|......:.:|.|.|
Human  2256 ------------SVVPEAKASRGGLPSLANG---------QGIYSVKPLLDTSRNLPATDEGDII 2299

  Fly  1770 PPAPATAPISSSF--TRKPLNRSSENLLDSC-------SSSSAPSLKTRAMSVENLNDVQRQYQL 1825
            .....:..::...  ||:          ..|       .|:|..|:|.|..|.|||.:       
Human  2300 SVQETSCLVTDKIKVTRR----------HYCYEQNWPHESTSFFSVKQRIKSFENLAN------- 2347

  Fly  1826 AKQLPQLHVADSMYSLNTATPTPSYASLP---RRSHGGSYSSGVERRISFSGEGGDAANRKAAIT 1887
                     ||...:.:.|:|..|.:|.|   |||.|...|..:       |..||||.|..   
Human  2348 ---------ADRPVAKSGASPFLSVSSKPPIGRRSSGSIVSGSL-------GHPGDAAARLL--- 2393

  Fly  1888 NILEQRRRSLSKLRGLVIPERPQLLEPILDLPEIKSQVKAASGEDSTDSGLGESHRSTVNRNCQL 1952
                  |||||                             :..|:.:::|               
Human  2394 ------RRSLS-----------------------------SCSENQSEAG--------------- 2408

  Fly  1953 GAGGAANNYRSILNTNQRRPLEQQLSQPPAKPPRTSLTPLQPRSMMIPPPPPPLDQESDTDSVFS 2017
                                               :|.|                |.:.:.|:.:
Human  2409 -----------------------------------TLLP----------------QMAKSPSIMT 2422

  Fly  2018 HTARVATPPEKFALTRTLSSETNTSIASSNTSTLTSGSSAGSQASCSSLG-STPAVDLTRRVLKS 2081
            .|.....|||                      |.:.||.:..:.|...|| .||.:.|...|.::
Human  2423 LTISRQNPPE----------------------TSSKGSDSELKKSLGPLGIPTPTMTLASPVKRN 2465

  Fly  2082 QVINGEAVALSSRKSILASAKCRSAKSRGQEEDNDSTDGEACSLANRRMKPISSYKLQQQQIQLG 2146
            :                                        .|:.:.:..|:|..|||:.:....
Human  2466 K----------------------------------------SSVRHTQPSPVSRSKLQELRALSM 2490

  Fly  2147 KQLVVDKLINV-----AAYVELTSDTDDSSRRSDTPAKISAMFIDEERKASFKGDPNQQAKVKVE 2206
            ..|  |||.:.     .:.|...::.:.:.|||..|   .|..:....|...:..|....     
Human  2491 PDL--DKLCSEDYSAGPSAVLFKTELEITPRRSPGP---PAGGVSCPEKGGNRACPGGSG----- 2545

  Fly  2207 QVKPMVLPMLLPSAKREPLKQQTTAELREKFERSAAAQAQTQNHSPVIHKVTQKPHHERFS-SLD 2270
               |..      ||...|.....|.|         |||              ..|....:| :||
Human  2546 ---PKT------SAAETPSSASDTGE---------AAQ--------------DLPFRRSWSVNLD 2578

  Fly  2271 SLASSSSGVSSTTQNVSTTQETATEFGSFSSLGSNQSLITAQDVQQIVEEADPPLKTPE--AFII 2333
            .|. .|:|.....|:|            .||:||..:::|      :::||....:..|  .||:
Human  2579 QLL-VSAGDQQRLQSV------------LSSVGSKSTILT------LIQEAKAQSENEEDVCFIV 2624

  Fly  2334 VLQRENPESSIGITLAGGSDYEAKEITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRES 2398
            :.::|.  |.:|.::|||:|.|.|.||:|::.|...|:::|.:.:||.:|:|||.|:.||.|...
Human  2625 LNRKEG--SGLGFSVAGGTDVEPKSITVHRVFSQGAASQEGTMNRGDFLLSVNGASLAGLAHGNV 2687

  Fly  2399 ISVLKTPRPEVVLVVTRSESLVV--KALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDL 2461
            :.||...:       ...::|||  |.:.:.|.     |:..|.||                   
Human  2688 LKVLHQAQ-------LHKDALVVIKKGMDQPRP-----SARQEPPT------------------- 2721

  Fly  2462 DLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARRQLSRGDAAKLS-TSELLE 2525
                 :|..|.....|.|....:             |.|...::.::|.|:..:.::. .:.||.
Human  2722 -----ANGKGLLSRKTIPLEPGI-------------ENTEQRMQVQQQHSQEGSPRIGRPTVLLG 2768

  Fly  2526 RAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFDSPLGNRPLIVKKVFMGG 2590
            .:|..|.::|..             .|.|||::|.|.|||.|::||..|..|:.||::|:|:.||
Human  2769 SSAVIRRSVAVH-------------DALCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGG 2820

  Fly  2591 AAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMKQLPLGPVKI 2634
            ||::...:..|||||:|||.....:...||||.||.:|.|||::
Human  2821 AAEQAGIIEAGDEILAINGKPLVGLMHFDAWNIMKSVPEGPVQL 2864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bbgNP_001246755.1 PDZ_signaling 90..177 CDD:238492 25/91 (27%)
ATP-synt_B <1084..>1109 CDD:304375 5/29 (17%)
PDZ_signaling 2331..2413 CDD:238492 29/81 (36%)
PDZ_signaling 2553..2634 CDD:238492 39/80 (49%)
PDZD2XP_005248326.1 PDZ_signaling 335..416 CDD:238492
PDZ_signaling 589..670 CDD:238492
PDZ_signaling 726..810 CDD:238492 24/93 (26%)
PDZ_signaling 2623..2694 CDD:238492 28/72 (39%)
PDZ 2785..2867 CDD:214570 38/80 (48%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 68 1.000 Domainoid score I9725
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11324
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.000

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