DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bbg and Mpdz

DIOPT Version :9

Sequence 1:NP_001246755.1 Gene:bbg / 39583 FlyBaseID:FBgn0087007 Length:2637 Species:Drosophila melanogaster
Sequence 2:NP_001292213.1 Gene:Mpdz / 17475 MGIID:1343489 Length:2069 Species:Mus musculus


Alignment Length:2339 Identity:472/2339 - (20%)
Similarity:773/2339 - (33%) Gaps:745/2339 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   619 NREIRFKIQTYESKTQD------EDKLPSLFDLVHSQ--ENDKDKDRDSDSLKTHNSITALLAAA 675
            ||.:: ..:..:||.::      ||||..|..::.|.  ....:.......||...:|..|..||
Mouse     8 NRALQ-AAERLQSKLKERGDVANEDKLSLLKSVLQSPLFSQILNLQTSLQQLKDQVNIATLATAA 71

  Fly   676 AAEAADLSRESPPPLVVGKCMKIVDDTNTTTCYTSSSSGEEDEDDLDASNREYICEDGEKLGPPE 740
            |                       |..:|....::..|..:.|..|.:.|.          |..|
Mouse    72 A-----------------------DHAHTPQFSSAVISNLQSESLLLSPNH----------GNLE 103

  Fly   741 LINGPGPSEAYFNMFWHSNMLPTIGEVE------------EEFSSLEPQSLTNGNL------VKS 787
            .:.|||....       .:..||..|::            |.|..|:|..   |.|      ::|
Mouse   104 ALPGPGAPAV-------MDGKPTCDELDQLIKNMAQGRHVEIFELLKPPC---GGLGFSVVGLRS 158

  Fly   788 EESKKLP--KMEVNAGGLAQLTDDKIADHD-ASATRADTRDEVTTNQTQEISSSSSSSVKSQKTT 849
            |...:|.  ..|:..|.:|. .|.::.:.| ..|......|:..|:| |.||.       .||..
Mouse   159 ENRGELGIFVQEIQEGSVAH-RDGRLKETDQILAINGQVLDQTITHQ-QAISI-------LQKAK 214

  Fly   850 TTTRVTTTKTS----SS---SSSSSCSSTVIPDVAFKLQPYEERDDILSEPITTIHEER-RVLSE 906
            .|.::...:.|    ||   |.|.|.:||:               ...|.|:...|.|. .::::
Mouse   215 DTVQLVIARGSLPPVSSPRISRSPSAASTI---------------SAHSNPMHWQHVETIELVND 264

  Fly   907 QKTLSESRTRDALTGEEQLVTSANSKSSSARFKKISSNDNLLDLGDEQDM----QEQPLTATITQ 967
            ...|.........||  .:|.:......:.:..::.|.|::|.:|| .|:    .||  .|.:.:
Mouse   265 GSGLGFGIIGGKATG--VIVKTILPGGVADQHGRLCSGDHILKIGD-TDLAGMSSEQ--VAQVLR 324

  Fly   968 ESSLRERLECPQDNQSIDRG----TLTLSERGKQLSEKEGLTTYTECETS-----EKESY-LEGQ 1022
            :...|.:|       .|.||    |...|..|..||.....|:....:.|     |.|:: :|..
Mouse   325 QCGNRVKL-------MIARGAVEETPASSSLGITLSSSTSSTSEMRVDASTQKNDESETFDVELT 382

  Fly  1023 QVLNGKG----GFVSQDENSDQPTYEREVSETLTIVNDGEKQVTKKL-----EQNKEIAGKKGAK 1078
            :.:.|.|    |::...:......:.:.::::..:.:||..|:..::     ...:....::..:
Mouse   383 KNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVE 447

  Fly  1079 LLKKTDEERRL-------EQEAQKLI--ESYQKVKKEAEKLYKLELADDDQGFDL---SAFEQAE 1131
            :|:.|.:..||       .|||:...  ::.:.|...||...|     |::...|   ::....|
Mouse   448 VLRHTGQTVRLTLMRKGASQEAELTSRGDTAKDVDLPAENCEK-----DEESLSLKRNTSILPIE 507

  Fly  1132 EEDKPEVSEEIKEVKDSQPVKVDIQIEEEVKTPNQVIGEVKVEDVNKEIKETVQVSQQEIKKEVK 1196
            ||..|.:|.|::|.:       |:|.|..:.|..|.|..:..|.|...:.:..:.|...|..|..
Mouse   508 EEGFPLLSAELEEAE-------DVQQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEAT 565

  Fly  1197 VSHQ------------ETKETFKSEEKDESNELKIVKEEVKVTHQDLREQIQEIEAVKVVHKEVK 1249
            |.|.            .:.:.|..:|..|.|.:.::.|    .|||:                |.
Mouse   566 VGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGINLLGE----NHQDV----------------VN 610

  Fly  1250 VIKESAKVTTTTSHKQATKEVIISKEDHKNDSALPAVSTTKVEIISPPLEDDLGYVLHKHIIFPQ 1314
            ::||.....|....::....:.:|:.|        ::....:|:...| ..|||           
Mouse   611 ILKELPIDVTMVCCRRTVPPIALSEMD--------SLDINDLELTEKP-HIDLG----------- 655

  Fly  1315 EKVKTAPTPLPKPKPKPPVPTNKPKMPVNLTKPKSAPPPVPSKRSELS------GSGGKPTPTQR 1373
            |.:.::.|                      ..|..|...|.....|:.      .:||:....::
Mouse   656 EFIGSSET----------------------EDPMLAMSDVDQNAEEIQTPLAMWEAGGQSIELEK 698

  Fly  1374 --RG----SLETAQPPKPLERIIV-------GVEQRDEPEKPQPIINLASVDLPNVAPNSKQATV 1425
              ||    .|:...|..|...:||       |:.::|..                          
Mouse   699 GSRGLGFSILDYQDPIDPANTVIVIRSLVPGGIAEKDGR-------------------------- 737

  Fly  1426 ETTPVVEMPPDELQFESHQLPDDGEKEKDLHQESNDLLSGSSSSSVTTPITTPILVSATSSMDSV 1490
                  ..|.|.|.|     .:|...|....:|:.:.|.|:.|..|...:..|:.:|......|.
Mouse   738 ------LFPGDRLMF-----VNDINLENSTLEEAVEALKGAPSGMVRIGVAKPLPLSPEEGYVSA 791

  Fly  1491 QSVIEVVNGMPIISNQQTDDDDIDEVAAYDDGMHLEAEGTKDVRPVQEVTTLTLDREHESDLGTL 1555
            :.                |.......|..:.|:..:|....|:..:.     |.|.|..::....
Mouse   792 KE----------------DAFLCSPHACKESGLSDKALFRADLALID-----TPDAESIAESRFE 835

  Fly  1556 SNHHSNISSISGINASSNIPAATLISSSIKKTSTEAATTKPAAPQIPGKMELLSSNTGTTTTTTT 1620
            |....:..|:....||        |.|....|.::.....|:.|..|.|         ..|:::.
Mouse   836 SQFSPDNDSVYSTQAS--------IFSLHDGTCSDGMNYGPSLPSSPPK---------DVTSSSE 883

  Fly  1621 ATHHLHQATTTKQLLVQDYLS---YASPPTYSR-LPPDGHEFPPNFSEPLIMHSHPLKVTTELSY 1681
            ....||  .:.::|..|:.|.   ..||||..| .|..|  ||        :..:......|..|
Mouse   884 VVLGLH--LSLEELYTQNLLQRQHAGSPPTDMRPAPTSG--FP--------ISDYTTTNAVEQKY 936

  Fly  1682 EIQKGGKDESSAPPLPKTGPPATVPRKVYRQDLVINVEPAPSLTRDYQRSLSGGTPRKPSDWRKD 1746
            |...           |...|.:.:|..:...:|      ||:|....|:.|:            |
Mouse   937 ECAN-----------PVAWPHSQLPSSLSTSEL------APALPAVAQKYLT------------D 972

  Fly  1747 EKSEKSVRDKIAMFSSNNELDAIPPAPATAPISSSFTRKPLNRSSENLLDSCSSSSAPSLKTRAM 1811
            :.|..|..:.:.:.|.:.|               :|.|........:.|....|::...|.....
Mouse   973 QSSLASDAESVNLQSMSQE---------------AFERTVTIAKGSSSLGMTVSANKDGLGVIVR 1022

  Fly  1812 SVENLNDVQRQYQLAKQLPQLHVADSMYSLN-----TATPTPSYASLPRRSHGG---SYSSG--- 1865
            |:.:...:.|..::|       |.|.:.|:|     :.|...:.|.|.|.|..|   .:|:.   
Mouse  1023 SIIHGGAISRDGRIA-------VGDCILSINEESTISLTNAQARAMLRRHSLIGPDIKFSAAPAD 1080

  Fly  1866 ----------------VERRISF----------------------------SGEGGDAANRKAAI 1886
                            .|.|:||                            .|||.::..:.||.
Mouse  1081 DRAPFYVITYVPAEHLEEFRVSFGQQAGGIMALDIFSSYTGRDIPELPEREEGEGEESELQNAAY 1145

  Fly  1887 TNILEQRR----RSLSK---------------------LRGLVIPERPQLLEPILDLPEIKS--- 1923
            ::..:.||    |..||                     :||:.|   ..:||   |.|..|:   
Mouse  1146 SSWSQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFI---KHVLE---DSPAGKNGTL 1204

  Fly  1924 ----QVKAASGEDSTDSGLGESHRSTVNRNCQLGAGGAANN-----YRSILNTNQRRPLEQQLSQ 1979
                ::....|.|..|:    ||...|.      |...|.|     .:||:|..::.||.   |.
Mouse  1205 KPGDRIIEVDGMDLRDA----SHEQAVE------AIRKAGNPVVFMVQSIINRPRKSPLP---SL 1256

  Fly  1980 PPAKPPRTSLTPLQP--RSMMIPPPPPPLDQESDTD------------SVFSHTARVATPPEKFA 2030
            |.:..|:.|.:...|  .|:.:.....|...||:|:            ||||........|...|
Mouse  1257 PHSLYPKYSFSSTNPFADSLQLTTDQAPSQSESETEKPALCNVPPSSPSVFSEMGSDCAQPSATA 1321

  Fly  2031 LTRTLSSETNTSIASSNTSTLTSGSSAGS------QASCSSLGSTPA--VDLTR----------- 2076
            ::.....|.....:..|... ..||..|.      :...|.||.:.|  .|.||           
Mouse  1322 VSEDEDKEDEFGYSWKNIQE-RYGSLTGQLHVIELEKGQSGLGLSLAGNKDRTRMSVFIVGIDPT 1385

  Fly  2077 ----RVLKSQV------INGEAVALSSRKSILASAKCRSAKSR-----------------GQEED 2114
                |..:.|:      |||:.:...|.::..:..||..:|.:                 |...|
Mouse  1386 GAAGRDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGIAAD 1450

  Fly  2115 NDST--------DGEACSLANRRMKPISS----YKLQ--QQQIQLGKQLVVDKLINVAAYVELTS 2165
            :.|:        :.|.||..:.....:||    |:|:  :.|..||..:..:..||   .|.:.|
Mouse  1451 SPSSTSDSPQNKEVEPCSTTSASAADLSSLTDVYQLELPKDQGGLGIAICEEDTIN---GVMIES 1512

  Fly  2166 DTDDSSRRSDTPAKIS--AMFIDEERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQ 2228
            .|:......|...|..  .:.:|:|..|   |.|       ||:     ...||.:||       
Mouse  1513 LTEHGGAAKDGRLKPGDHILAVDDEVVA---GCP-------VEK-----FISLLKTAK------- 1555

  Fly  2229 TTAELREKFERSAAAQAQTQNHSPVIHKVTQKPHHERFSSLDSLASSSSGVSSTTQNVSTTQETA 2293
            .|.:|..:.|..|..                             |..||.|:.:.:....:|..|
Mouse  1556 ATVKLTVRAENPACP-----------------------------AVPSSAVTVSGERKDNSQTPA 1591

  Fly  2294 TEFGSFSSLGSNQSLITAQDVQQIVEEADPPLKTPEAF--------II-----VLQRENPESSIG 2345
                           :.|.|::.|...:..  .||..|        ||     .::....::.:|
Mouse  1592 ---------------VPAPDLEPIPSTSRS--STPAVFASDPATCPIIPGCETTIEISKGQTGLG 1639

  Fly  2346 ITLAGGSDYEAKEITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLKTPRPEVV 2410
            :::.||||.....|.||::.....|.|||||..||:||.|||:.:|..||.|:|:||:.....|.
Mouse  1640 LSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVR 1704

  Fly  2411 LVVTRSESLVVK---------------------ALTKKRSSLGSLSSLNEKPTELDYE------- 2447
            |.:.|.|:...:                     ::..||:..|...|...|....|.:       
Mouse  1705 LTLYRDEAPYKEEDVCDTFTIELQKRPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGD 1769

  Fly  2448 ----------RKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEA--- 2499
                      |.......:..|...|..|:.|.|.  |...|......|.|.:.:.:....:   
Mouse  1770 QILMVNGEDVRHATQEAVAALLKCSLGAVTLEVGR--VKAAPFHSERRPSQSSQVSESSLSSFTP 1832

  Fly  2500 TIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGARCVEIVK---DS 2561
            .::||              :|||.||..:: :||:|:||:           |.|.|||.|   ||
Mouse  1833 PLSGI--------------NTSESLESNSK-KNALASEIQ-----------GLRTVEIKKGPADS 1871

  Fly  2562 CGLGFSIEGGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMK 2625
              ||.||.||..||||:.|:.:..:...|.|.:|.::|.||.|::|.|.||..||...|.|.||
Mouse  1872 --LGLSIAGGVGSPLGDVPIFIAMMHPNGVAAQTQKLRVGDRIVTICGTSTDGMTHTQAVNLMK 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bbgNP_001246755.1 PDZ_signaling 90..177 CDD:238492
ATP-synt_B <1084..>1109 CDD:304375 7/33 (21%)
PDZ_signaling 2331..2413 CDD:238492 33/94 (35%)
PDZ_signaling 2553..2634 CDD:238492 35/76 (46%)
MpdzNP_001292213.1 L27_2 6..63 CDD:117611 12/55 (22%)
PDZ_signaling 140..222 CDD:238492 22/93 (24%)
PDZ_signaling 256..335 CDD:238492 16/90 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 348..372 5/23 (22%)
PDZ 375..464 CDD:214570 12/88 (14%)
PDZ_signaling 553..622 CDD:238492 17/88 (19%)
PDZ_signaling 694..777 CDD:238492 20/119 (17%)
PDZ_signaling 994..1064 CDD:238492 14/76 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1125..1144 3/18 (17%)
PDZ_signaling 1151..1242 CDD:238492 22/106 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1278..1313 8/34 (24%)
PDZ 1349..1434 CDD:214570 16/84 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1449..1473 5/23 (22%)
PDZ_signaling 1483..1563 CDD:238492 25/104 (24%)
MPDZ_u10 1564..1625 CDD:293272 16/106 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1571..1611 11/56 (20%)
PDZ 1626..1710 CDD:214570 30/83 (36%)
PDZ_signaling 1722..1802 CDD:238492 10/79 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1809..1848 10/52 (19%)
PDZ_signaling 1859..1944 CDD:238492 35/77 (45%)
PDZ_signaling 1985..2068 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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