DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and FRMPD2

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	NP_001018081.4	Gene:	FRMPD2 / 143162	HGNCID:	28572	Length:	1309	Species:	Homo sapiens

Alignment Length:	1416	Identity:	258/1416 - (18%)
Similarity:	436/1416 - (30%)	Gaps:	545/1416 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1453 KDLHQESNDLLSGSSSSSVTTPITTPILVSATSSMDSVQSVIEVVNGMP-----IISNQQTDDD- 1511
            :||..:|:|.        |..|.:.  |:||..|: |.|..:..:...|     ::..|..|:.
Human    46 EDLRNDSSDY--------VVCPWSA--LLSAAGSL-SFQGRVSHIEAAPFKAPELLQGQSEDEQP 99

  Fly  1512 DIDEVAAYDDGMHLEAEGTKDVRPVQEV-------------------------TTLTLDREHESD 1551
            |..::..|..||.|.......|.|.|.:                         :.|...|.||.:
Human   100 DASQMHVYSLGMTLYWSAGFHVPPHQPLQLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKE 164

  Fly  1552 -------------------LGTLSNHHSNISSISGINASSNIP--AATLISSSIKKTSTEAATTK 1595
                               |||:|.....:     :..||::.  .:.|:...::.||:|:
Human   165 VSVYPAPAGLHIRRLVGLVLGTISEVEKRV-----VEESSSVQQNRSYLLRKRLRGTSSES---- 220

  Fly  1596 PAAPQIPGKMELL-SSNTGTTTTTTTATHHLHQATTTK---QLLVQDYLSYASP----------- 1645
            ||| |.|   |.| .......:|.|.::...|.:|.|.   .|||...|..|.|
Human   221 PAA-QAP---ECLHPCRVSERSTETQSSPEPHWSTLTHSHCSLLVNRALPGADPQDQQAGRRLSS 281

  Fly  1646 -----------PT-------------YSRLPPDGHEFPPNF-----SEPLIMHSHPLKVTTELSY 1681
                       ||             :||         |.|     ..|:.:|. |..|.|
Human   282 GSVHSAADSSWPTTPSQRGFLQRRSKFSR---------PEFILLAGEAPMTLHL-PGSVVT---- 332

  Fly  1682 EIQKGGKDESSAPPL-----------PKTGPPATVPRKVYRQDLVINVEPAPSLTRDYQRS---- 1731
               |.||...:...|           .|....:||...........|:|........|.:|
Human   333 ---KKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFF 394

  Fly  1732 -LSGGT---PRKPSDWRKDEKSEKSVRD------KIAMFSSNNELDAIPPAPATAPISSSFTRKP 1786
             |...|   ...|..||  |:.:|:..:      :|..|.|:..|           :..|.||..
Human   395 FLDSETRLCKIAPEGWR--EQPQKTSMNTFTLFLRIKFFVSHYGL-----------LQHSLTRHQ 446

  Fly  1787 LN-RSSENLLDS---CSSSSAPSLKTRAMSVENLNDVQRQYQLAKQLPQLHVADSMYSLNTATPT 1847
            .. :..:::|:.   |:......|...|:..|..|..:.|   .:..|..||.|.:
Human   447 FYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQ---VESKPYFHVEDYI--------- 499

  Fly  1848 PSYASLPRRSHGGSYSSGVE--RRISFSGEGGDAANRKAAIT-----------NILEQRRRSLSK 1899
            |  |||..|.........|.  .|:|.:..|.||..:...:|           .:..::||...:
Human   500 P--ASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEE 562

  Fly  1900 L------RGLVIPERPQLLEPILDLPEIKSQVKAA--------SGEDS--------TDSGLGESH 1942
            :      :|:::             .|:|:..:.|        :|:.|        |.|..|:.|
Human   563 MALGICAKGVIV-------------YEVKNNSRIAMLRFQWRETGKISTYQKKFTITSSVTGKKH 614

  Fly  1943 RSTVNR-----------------NCQLGAGGAAN---NYRSILNTNQRRPLEQQLSQPPAKPPRT 1987
            ....:.                 |.|:|:|..::   ::...:......|..|..|:|
Human   615 TFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMANLSPAHQARSKP------- 672

  Fly  1988 SLTPLQPRSMMIPPPPPPLDQESDTDSVFSHTARVATPPEKFALTRTLSSETNTSIASSNTSTLT 2052
             |..:|                           |::....:..::| |.......:::|..:...
Human   673 -LIWIQ---------------------------RLSCSENELFVSR-LQGAAGGLLSTSMDNFNV 708

  Fly  2053 SGSSAGSQASCSSLGSTPAVDLTRRVLKSQVINGEAVALSSRKSILASAKCRSAKSRGQEEDNDS 2117
            .||   .:|....:|.:|...  |..|||..:..:.:...|    |:....:|.
Human   709 DGS---KEAGAEGIGRSPCTG--REQLKSACVIQKPMTWDS----LSGPPVQSM----------- 753

  Fly  2118 TDGEACSLANRRMKPISSYKLQQQQIQLGKQLVVDKL-----------INVAAYVELTSDTDDSS 2171
               .|.|..|||...|:         :.|:::|...|           ||...|          |
Human   754 ---HAGSKNNRRKSFIA---------EPGREIVRVTLKRDPHRGFGFVINEGEY----------S 796

  Fly  2172 RRSDTPAKISAMFIDEERKASFKGDPNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELREK 2236
            .::|....||::         ..|.|.::||.    :||
Human   797 GQADPGIFISSI---------IPGGPAEKAKT----IKP-------------------------- 822

  Fly  2237 FERSAAAQAQTQNH--------SPVIHKVTQKPHHERFSSLDSLASSSSGV--------SSTTQN 2285
                 ..|....||        :..:..:...|     .:::.:.|.|.||        .::|.|
Human   823 -----GGQILALNHISLEGFTFNMAVRMIQNSP-----DNIELIISQSKGVGGNNPDEEKNSTAN 877

  Fly  2286 VSTTQETATEFGSFSSLGSNQSLITAQDVQQIVEEAD---------------------------- 2322
            ...:......||...||.|:     .||..:..||.|
Human   878 SGVSSTDILSFGYQGSLLSH-----TQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCP 937

  Fly  2323 ---PPLKTPEAFIIVLQRENPESSIGITLAGGSDYEAK--EITIHKILSNTPAAKDGRLKKGDRI 2382
               |.:...|.:.:.|.:|  :.::|.::.||.:....  .|.:..|:...||||:|::.:|||:
Human   938 PSPPEISAGEIYFVELVKE--DGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRL 1000

  Fly  2383 LAVNGMSMRGLTHRESISVLKTPRPEVVLVVTRSESLVVKALTKKRSSLGSLSSLNEKPTELDYE 2447
            |.|:|:.:.||||::::..|..|.....||:.|......:.......|:|.             |
Human  1001 LQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGD-------------E 1052

  Fly  2448 RKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRARRQLSR 2512
            |                            |..|..:..|.:|:|.                 :|.
Human  1053 R----------------------------TAVSLVTALPGRPSSC-----------------VSV 1072

  Fly  2513 GDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFDSPLG 2577
            .|..|.                  |::.:..   |:|.|...|::.|:||           |.|.
Human  1073 TDGPKF------------------EVKLKKN---ANGLGFSFVQMEKESC-----------SHLK 1105

  Fly  2578 NRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMKQLP 2628
            :..:.:|::|.|..|::...:..||.||::||.||..:...:..:.::..|
Human  1106 SDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAP 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	25/83 (30%)
		PDZ_signaling	2553..2634	CDD:238492	19/76 (25%)
FRMPD2	NP_001018081.4	KIND	15..197	CDD:214801	31/166 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..249		12/42 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..302		4/35 (11%)
		B41	346..550	CDD:214604	44/230 (19%)
		FERM_C_PTPH13	546..647	CDD:270008	16/113 (14%)
		PDZ_signaling	773..857	CDD:238492	19/142 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	859..880		5/20 (25%)
		PDZ	947..1034	CDD:214570	27/88 (31%)
		PDZ	1078..1167	CDD:214570	23/111 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810