DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and il16

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	XP_021333386.1	Gene:	il16 / 100534674	ZFINID:	ZDB-GENE-130103-3	Length:	1540	Species:	Danio rerio

Alignment Length:	1161	Identity:	226/1161 - (19%)
Similarity:	411/1161 - (35%)	Gaps:	339/1161 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1564 SISGINASSNIPAATLISSS-----IKKTSTEAATTKPAAPQIPGKMELLSSNTGTTTTTTTATH 1623
            |:.|.|:|...|.:...|..     :.:::::....:...|.|....|...|.......:|||..
Zfish   605 SMDGCNSSLRRPESCCHSRQKCMRCVDRSTSQLTCRRTQKPMIRSCSEGAYSQRCCIPNSTTAQS 669

  Fly  1624 HLH----QATTTKQLLVQDYLSYASPPTYSRLPPDGHEFPPNFSEPLIMHSHPLKVTTELSYEIQ 1684
            .||    ..||..:..:.:.||.:|      ...|.:..|         :..|:....:.::::
Zfish   670 FLHTDHVSLTTNSETSLNNTLSQSS------FTDDDYNIP---------YKCPVNFNGKQTFDV- 718

  Fly  1685 KGGKDESSAPPLPKTGPPATVPRKVYRQDLVINVEPAPSLTRDYQRSLSGGTPRKPSDWRKDEKS 1749
                :.||.        ....|||..||...::.:.|        .::|.|:.|
Zfish   719 ----NASSG--------LVNQPRKYCRQQQEVSSQEA--------LNVSSGSSR----------- 752

  Fly  1750 EKSVRDKIAMFSSNN---------------------------ELDAIPPAPATAPISSSFTR-KP 1786
            :..|:::..|.|.:|                           ||.....|..:.|.|.|..| ..
Zfish   753 DSPVKEEDLMLSQSNCQFFCSLYRALRKISRLLFKNEVVEHAELGTKASACISEPKSDSTHRGDR 817

  Fly  1787 LNRSSENLLDSCSSSSAPSLKTRAMSVENLNDVQRQYQLAKQLPQLHVADSMYSLNTATPTPSYA 1851
            |::..|.....|.||....|:.:|                      |:     .::|..|...:.
Zfish   818 LHKDPECSSQVCGSSKRVGLRRQA----------------------HL-----EVSTDQPLDPWV 855

  Fly  1852 SLPRRSHGGSYSSGVERRISFSGEGGDAANRKAAITNILEQRRRSLSKLRGLVIPERPQLLEPIL 1916
            .|.......||.|.     :.|...||:.....|......:..::.|..:|  .|..|:......
Zfish   856 KLTDSPENQSYCSK-----TMSDHNGDSEVNGTASETTESKSEQATSVKKG--PPVAPKSARARQ 913

  Fly  1917 DLPEIKSQVKAASGEDSTDSGLGESHRSTVNRNCQLGAGGAANNYRSILNTNQRRPLEQQLSQPP 1981
            .:..||      ||:..|::...:....:.......|....|.:....|:..|:....:..|.|.
Zfish   914 SMKSIK------SGKPITEAFRNQQDNRSHETGRTFGISSRAASSGGNLSIRQKISSFETFSSPD 972

  Fly  1982 AKPPRTSLTPLQPRSMMIPPPP-PPLDQESDTDSV-FSHTARV--------------ATPPEKFA 2030
            ...        :|...|.|... ||.::.:.|.|. :|:..|.              :|||  .:
Zfish   973 GSE--------RPSWRMAPTASVPPTEKTTKTSSADYSNADRTRVNTSNLRNNDYCQSTPP--IS 1027

  Fly  2031 LTRTLSSETNTSIASSNTSTLTSGSSAGSQASCSSLG-STPAVDLTRRVLKSQVINGEAVALSSR 2094
            .|..||.|.:||:...:...:...|::....:|.|:. ..|.||.|..:         ..|:.:.
Zfish  1028 ATTLLSEEHSTSLILESHPGVEKQSTSHDSETCKSIPVEEPTVDPTEEI---------TTAVETE 1083

  Fly  2095 KSILASAKCRSAKSRGQEEDNDSTDGEACSLANRRMKPISSYKLQQQQIQLGKQLVVDKLINVAA 2159
            :.:::|||             .|.|.|        .||:||.:.:|:.:...|..|..:.:..|
Zfish  1084 QELVSSAK-------------SSVDTE--------HKPVSSSETEQEPVSSTKSSVETEPVTSA- 1126

  Fly  2160 YVELTSDTDDSSRRSDTPAKISAMFIDEERKASFKGDPNQQAK---VKVEQVKPMVLPMLLPSA- 2220
                .:..:..|...|.|:....    ..|.:|.|..|.::|:   .....::...|| |.||:
Zfish  1127 ----ETKQEPVSSEKDLPSVTHV----PRRSSSSKEAPGEKAEDAGTHAVSLRTRSLP-LSPSSD 1182

  Fly  2221 -------KREPL-------KQQTTAELRE----------KFERSAAAQAQTQNHSPVIH-KVTQK 2260
                   :.|.|       .|.::|.:|.          :.....:|...:..|:|:.. ...:.
Zfish  1183 GPISSGLEGESLGIILSFSNQVSSALMRSMQSLPQSPCIRLGNPWSAPPGSPLHNPIEEDSAAEN 1247

  Fly  2261 PH-------HERFSSLDSLASSSSGVSSTTQNVSTTQ---ETATEFGSFSSLGSNQSLITAQDVQ 2315
            ||       :|:..|: |||..........:...|..   |.|....|.:...|..|::...::|
Zfish  1248 PHASTALENNEKGFSV-SLAELRERTIERGEECKTDDWKPEQALTSASAACAQSMLSVLPQPEIQ 1311

  Fly  2316 QIVEEA----DPPLKTPEAFIIVLQRENPESSIGITLAGGSDYEAKEITIHKILSNTPAAKDGRL 2376
            ::::|.    :..|:..|...:|:..:...:.:|.::|||.|.|.|..|:|::..:..||::|.:
Zfish  1312 RMIQEVKDLDEDTLRQLEDIHVVILHKEEGAGLGFSIAGGIDLENKATTVHRVFPSGLAAQEGTI 1376

  Fly  2377 KKGDRILAVNGMSMRGLTHRESISVLKTPRPEVVLVVTRSESLVVKALTKKRSSLGSLSSLNEKP 2441
            :|||.:|::||.:::.:||.::.::|:..|       |..:::||  ::|.:.:.|..::.||
Zfish  1377 EKGDEVLSINGQTLKNVTHSDATAILRQSR-------TLKQAVVV--VSKNKDAEGKSANANE-- 1430

  Fly  2442 TELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSPPQPASLHDEDAEATIAGIRA 2506
                                     |:.:|                        .||::|||
Zfish  1431 -------------------------SSCSG------------------------GAESSIAG--- 1443

  Fly  2507 RRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGG 2571
                                                :|    ||.....|:.|::.|:|||:|||
Zfish  1444 ------------------------------------DD----GGEVVTFELEKNAGGVGFSLEGG 1468

  Fly  2572 FDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSRMTRVDAWNYMKQL 2627
            ..|..|:|||.|.::|.|..|::.. :::|||:|.|..:|...:||.:||..:|.|
Zfish  1469 KGSISGDRPLAVNRIFTGSDAEQKG-LKSGDEVLQIQDSSLQGLTRFEAWTLIKNL 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	23/81 (28%)
		PDZ_signaling	2553..2634	CDD:238492	30/75 (40%)
il16	XP_021333386.1	PDZ_signaling	350..433	CDD:238492
		PDZ_signaling	489..571	CDD:238492
		MGC-24	620..>696	CDD:310122	15/81 (19%)
		GREB1	<795..>990	CDD:318077	44/242 (18%)
		Atrophin-1	1006..>1234	CDD:331285	51/269 (19%)
		PDZ_signaling	1331..1406	CDD:238492	22/74 (30%)
		PDZ	1448..1535	CDD:214570	30/77 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9486
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25655
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11324
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.100