Protein Alignment bbg and pdzd2

DIOPT Version :10

• Sequence 1: NP_648705.2
• Gene: bbg / 39583
• FlyBaseID: FBgn0087007
• Length: 2637
• Species: Drosophila melanogaster
• Sequence 2: XP_031750652.1
• Gene: pdzd2 / 100495319
• XenbaseID: XB-GENE-6044665
• Length: 2535
• Species: Xenopus tropicalis
• Alignment Length: 2748
• Identity: 527/2748 - (19%)
• Similarity: 918/2748 - (33%)
• Gaps: 948/2748 - (34%)

  Fly   434 IKLHLPAPKQQSPQSKSRIPIVSTPTAQKTVPKPVSPTMNG--TPLSSNIPRLLQKQK-SETDLK 495
            ||...|.|.....:|.:     |.|.|..:....|..|.||  |.....|.|..::.| ||..::
 Frog   180 IKRKAPLPPSHGSKSSA-----SEPKAASSSHPSVRTTQNGKRTRKFGVISRTGKESKDSEEAVQ 239

  Fly   496 LNLYRSKSK------------ESSPRPPLQRANSAEAPERTFIPVLLNGNSKSSNS--------- 539
            .|.:.|..:            ....:....|::.|:.......|   ||:...|.|
 Frog   240 ENGHYSPMEVDGSHSADEALGNDGDKQRTSRSSDADVQHGYQFP---NGDCSDSRSNDHPARNEG 301

  Fly   540 --------LESVSSIGSSSSG--NSVRSPKGPKPKPPERVQSLQKTQIPKLQA---LPTTPPQQI 591
                    |:....:|...:|  .|.|||.|......|...|..:.  .:|:|   |.....|.:
 Frog   302 CCIWKMHMLKGADGLGIQITGGRGSKRSPHGIVVAHVEEGGSADRD--GRLKAGDELLMINGQSL 364

  Fly   592 PKLSMQTFKQSPPTPRSTPVGTPSPTSNREIRFKIQTYESKTQDEDKLP--SLFDLVHS------ 648
            ..||.|   ::....||: :|.        ::..:.:.||...|..|.|  ||.|||.:
 Frog   365 VGLSHQ---EAVALLRSS-MGI--------VQLVVASRESSNVDFCKYPSTSLPDLVSASSAQDV 417

  Fly   649 ------QENDK---DKDRDSDSLKTHNSITALLAAAAAEAADLSRESPPPLVVGKCMKIVDDT-- 702
                  :||::   ::.:|..:..:|.       ||.:|......:....:..|.|.   ..|
 Frog   418 GASSDDKENEEPYVEEGQDYGTSPSHQ-------AAESETDKFQEKGSSEVPKGVCR---SPTLG 472

  Fly   703 NTTTCYTSSSS---------GEEDE-----DDLDASNREYICEDGEKLGPPELINGPGPSEAYFN 753
            |:...|.|.|.         ||:||     .||...|.:.|...|.|...|:.::..|..:.|..
 Frog   473 NSLLKYRSRSQGSGSRLESVGEDDELTVANGDLYRDNGDKISRGGRKHSLPQQLDSVGSRQDYNI 537

  Fly   754 MFWHSNMLPTIGEVEEEFSSLEPQSLTNGNLVKSEESKKLPKMEV----NAGGLAQLTDDKIADH 814
            :...:..|.|: :||..:...:|..::|..|:|. :.|.|....|    :|.|...:....|..:
 Frog   538 VKKTTRSLSTV-QVESPWRLAQPSIISNIVLMKG-QGKGLGFSIVGGQDSARGRMGIFVKTIFSN 600

  Fly   815 DASATRADTR----DEVTTNQTQEISSSSSSSVKSQKT--------------TTTTRV------- 854
            .|:|  ||.|    ||:.     |::..|...:..|:.              |..||:
 Frog   601 GAAA--ADGRLKEGDEIL-----EVNGESLQGLTHQEAIHKFKQLKKGVVTLTVRTRLRSPSLTP 658

  Fly   855 --TTTKTSSSSSSSSCSS--TVIP------DVAFKLQPYEERDDILSEPITTIHEERRV------ 903
              |.|..|.|||.:|..|  |.:|      ..:...:....:|.|:.|  .|:::|..|
 Frog   659 CPTPTMMSRSSSPNSNISLGTSMPGSEDGDSTSGSRKGPGPKDRIIME--VTLNKEPGVGLGIGA 721

  Fly   904 --LSEQKTL-----------SESRTRDALTGEEQLVTSANSKSSSARFKKISSNDNLL-DLG--- 951
              |:.:.:.           |.::....|:..:|::   .:.|.|.|...:|....:| :.|
 Frog   722 CCLTLENSSPGIYIHSLAPGSVAKMDGRLSRGDQIL---EADSVSLRHAALSEAYAILSECGPGP 783

  Fly   952 -------------DEQDMQEQPLTATITQES-----SLRERLECPQD-------------NQSID 985
                         .||:|.| .:|.|..:||     |:...|:.|..             :.::.
 Frog   784 VSLIISRHPNPKVSEQEMDE-VITRTTHRESKDSFHSMGLHLKSPSPACKPKHGDGPTSLSWTMK 847

  Fly   986 RGTLTLSERGKQLSEKEGLTTYTECETSEKESYLE-------GQQVLNGKGGFVSQDENSDQPTY 1043
            |.....|.:|...||.| |:.|...:.....|:.:       .::.|....|..|.|:||..|..
 Frog   848 RFLEPASRQGSVSSEAE-LSQYFSQDAPSHSSFSDTVATGSSDEEQLRPASGSNSLDDNSAPPCA 911

  Fly  1044 EREVSETLTIVNDGEKQVTKKLE---------------QNKEIAGKKGAKLLKKTDEERRLEQEA 1093
            .            ..|:...|.|               .||.|...:.:. |..:.:..|.....
 Frog   912 A------------NAKECGAKAECCIPASHRNGNIPSPCNKHIVSTRQSS-LNSSPQSIRSPLLR 963

  Fly  1094 QKLIESYQ--------KVKKEAEKLYKLEL---ADDDQGFDLSAFEQAEEEDKPEVSEEIKEVKD 1147
            |:.|.||:        .:.::.|..||..|   ||:|.|..:|..         :|.|||.:  .
 Frog   964 QRRIVSYEDEDGSEDGDISRKDEGNYKDHLKKNADEDSGIVMSTL---------DVDEEIPD--H 1017

  Fly  1148 SQPVKVDIQIEEEVKTPNQVIG-EVKVEDVNKEIKETVQVSQQEIKKEVKVSHQETKETFKSEEK 1211
            :.|||    ...|..|  .:.| .|:.||.:                   |.|......|..:..
 Frog  1018 NLPVK----CASEAGT--SLCGSSVESEDSS-------------------VEHMVDSPFFAIKSF 1057

  Fly  1212 DESNELKIVKEEVKVTHQDLRE----QIQEIEAVKVVHKEVKVIKESAKVTTTTSHKQATKEVII 1272
            |.|     .|.:.:.....|:|    .|:...:.|:.||.|..:|....:...:|
 Frog  1058 DYS-----AKADARPCSLALKEPTEGPIENKRSPKLEHKAVTRVKSMMSIEYPSS---------- 1107

  Fly  1273 SKEDHKNDSALPAVSTTKVEIISPPLEDDLGYVLHKHIIFPQEKVKTAPTPLPKPKPKPPVPTNK 1337
                                                                ||||.:.....:|
 Frog  1108 ----------------------------------------------------PKPKAEESCLPSK 1120

  Fly  1338 PKMPVNLTKPKSAPPPVPSKRSELSGSGGKPTPTQRRGS--LETAQ---------------PPKP 1385
            |..|:.|.|                    ||..::..|.  .:|.|               ...|
 Frog  1121 PTKPLPLVK--------------------KPEGSEHSGKCITDTVQLFCSEYESVGLDLEIKESP 1165

  Fly  1386 LERIIVGVEQRDEPEKP--------QPIINLASVDLPNVAPNSKQATVE--------TTPVVEMP 1434
            |..||.|:....|.||.        ..||::..:   .|:..|.|.|.:        .|..|..|
 Frog  1166 LSVIITGLRPAREGEKDSVGKLAAGDEIISINGI---QVSEMSYQQTCDFIQCLPSSVTLGVRKP 1227

  Fly  1435 PDELQFESHQLPDDG-------EKEKDLHQESNDLLSGSSSSSVTTPITTPILVSATSSM----- 1487
            ...:...||.:...|       |:.:.|.||::.......::..:||  ..:.:.|.:|:
 Frog  1228 LSAVDRLSHIIMASGGDQQGPVEQVEILRQENSQCKGPQHTADCSTP--AKVTIEAGNSLTIQCL 1290

  Fly  1488 -----DSVQSVIEVVN-----GMPI--ISNQQTDDDDIDEVAAYDDGMHLEAE------------ 1528
                 .:|.::.:.:|     |.|.  .:......::::...|...|..::||
 Frog  1291 EAGNDSTVTNIDDFINELDFSGAPSCDFAKDSNTTEEMEACVASGQGNRVDAETEEAKTELCSSI 1355

  Fly  1529 --------GTKDVRPVQEVTTLTLDREHESDLGTLSNHHSNISSISG---------INASSNIPA 1576
                    .::::.....:.:|:::::...|...||::..|.||::.         :::|.::|.
 Frog  1356 TNFDESTSQSENILAFSVLDSLSMEKKFAVDKSCLSSYSRNFSSLTEEDFSLSDQILSSSLDLPI 1420

  Fly  1577 ATLISSSIKKTSTEAATTKPAAPQIPGKMELLSS--NTGTTTTTTTAT----------------- 1622
            :..:::....:.:...:|.          :::||  |....:...|||
 Frog  1421 SMYVTAEDSDSESFLDSTS----------DMISSLQNQSCMSELQTATDSEEEQIEICCDIKKGD 1475

  Fly  1623 ---------HHLHQA--------------------------TTTKQLLVQDYLSYASP---PTYS 1649
                     |.|:.|                          |:..::.|::.::...|   ||.|
 Frog  1476 SGAHQFYDVHQLYPAATLSETPKDLPDERCGGNTLPGFGHYTSVDRVTVENIVNSGHPDASPTMS 1540

  Fly  1650 RLPPDGHEFPPNFSEPLIMHSHPLKVTTELSYEIQKGGKDESSAPPLPKTGPPATVPRKVYRQDL 1714
            .|..|..|.|.. ||..:.....|:|...::..::....|..:...:|.:      ...|||..|
 Frog  1541 LLNNDSQELPCR-SEISLNDYSALQVQDPMTLGVKDNSTDVHNVGLVPLS------EGNVYRCHL 1598

  Fly  1715 --------------VINVEPAPSLTRDYQRSLSGGTPRKPSDWRKDEK------SEKSVRDKIAM 1759
                          .|:....||.|              ..|..:|||      .|..|..:.|.
 Frog  1599 GPLDSGENMSAVEETIDSHVIPSCT--------------IVDPSEDEKCVTRSSMEPEVCPQEAS 1649

  Fly  1760 FSSNNE----------------LDAIP-----PAPAT-----------APISSSFTR-KPLNRSS 1791
            .::.||                .:.:|     .:|||           .|:|...|. |...:||
 Frog  1650 CANTNEGPITNCTVSTSNVQVKRETLPEGTTKKSPATRNCNLDMYKPNVPLSKLHTDIKTTLKSS 1714

  Fly  1792 ENLLDSCSSSSAPSLKTRAMSVENLNDVQRQYQLAKQLPQLHVADSMYSLNTATPTPSYASLPRR 1856
            .::|::..|...|.||  .:|:::.|..|.|...||       ||....|   :|.||...|.:|
 Frog  1715 LDILNTQVSKPGPKLK--GLSIKSKNKEQAQNHPAK-------ADDFRKL---SPQPSPKLLAKR 1767

  Fly  1857 SHGGSYSSGVERRISFSGEGGDAANRKAAITNILEQRRRSLSKLRGLVIPERPQLLEPILDLPEI 1921
            :.              ..:|..||..:|..:.::.::                         ||.
 Frog  1768 AS--------------MADGSTAARDRAVRSPVMTKK-------------------------PEH 1793

  Fly  1922 KSQVKAASGEDSTDSGLGESHRSTVNRNCQLG-----AGGAANN-----------------YRSI 1964
            |:.:...|.:....:.:..:..:..::|.::.     .|..||:                 .::|
 Frog  1794 KTGLSVQSVDSKASANVSANSSTCSSKNDKMSPFSRRTGKCANDKSKDEGFSLRVNSSECPNKTI 1858

  Fly  1965 LN------------TNQRRPLEQQLSQPPAKPPRTSLTPLQPRSMMIPPPPPPL------DQESD 2011
            .:            |.:|.|.:.....|.....|.:...::..|.:    |..|      ...||
 Frog  1859 TSSDSGTKELIEDITAERVPQQMATEGPETHDIRRTFIEVKLSSAL----PHALTSATRRQDGSD 1919

  Fly  2012 TDSVFS--HTARVATPPE--------KFALTRTLSSETNTSIASSNTSTLTSGSS--AGSQASCS 2064
            ..::.:  |.|.|...|.        | .:|||.|...:..|...:..|.|.|.:  ..||.|..
 Frog  1920 KANILTNDHFANVYMSPRINNKSIVCK-PVTRTYSMPAHLPIFMDDEGTQTKGQNHCLISQGSVD 1983

  Fly  2065 SL--------GSTPAVDLTRRVLKSQVINGEAVALSSRKSILASAKCRSAKSRGQEEDNDSTDGE 2121
            .:        .::|||  .:..|||::...:. .:|:.|.:..|...||.:.....|.|...|
 Frog  1984 CVLEKYLHAGNNSPAV--AQNQLKSKLPTQDG-QVSNEKYVSRSEIMRSIRRNYYYELNWCHD-- 2043

  Fly  2122 ACSLANRRMKPISSYKLQQQQIQLGKQL---------VVD------------------------K 2153
                      |:||..: :|:|:..:.|         |:|                        .
 Frog  2044 ----------PLSSLTV-KQRIKSFENLAHFDKTVMKVIDMNHSPFSSKPPICRRSSGSVPSEGS 2097

  Fly  2154 LINVAAYV--ELTSDTDDSSRRS------DTPAKISAMFIDEERKASFKGDP-NQQAKVKVEQVK 2209
            |.:.:.|:  .|:|..|..|..:      .||..::...|::....:....| |::::.:.::..
 Frog  2098 LHDASRYLRRSLSSCCDSHSEVTLAAPIETTPPSVALAVIEKSASDNITQTPVNEESRTEKKESS 2162

  Fly  2210 PMVLPMLLPSAKREPLKQQTTAELREKFERSAAAQAQTQNHSPVIHKV-----TQKPHHERFSSL 2269
            |       |:|:....| .:::.:|....||...:.:..: .|.:.|:     |.:|...:|.:.
 Frog  2163 P-------PAAQIRKNK-TSSSHIRPSLSRSKIRELRALS-MPDLDKLCTDDFTVEPKAPQFKTE 2218

  Fly  2270 -------------DSLASSSSGVSSTTQNVSTTQETATEF------GSFS----SLGSNQSLITA 2311
                         .::..:||.:|:|.....:...|||:.      |:.|    ::...|.:::.
 Frog  2219 LEIIPARLCDLPGQNMEPASSNLSNTGLMGCSLSGTATDLDESRPDGTLSRKSWAISLEQLMVST 2283

  Fly  2312 QD--------------------VQQIVEEADPPLKTPEAFIIVLQRENPESSIGITLAGGSDYEA 2356
            ||                    :|:|..:::   |....|.:||.:|. .:.:|.::|||.|.|.
 Frog  2284 QDQQNLQAVLTSVSSRSDIISLIQEIKTQSE---KREGVFFVVLNKEE-GTGLGFSIAGGIDLEQ 2344

  Fly  2357 KEITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLKTPRPEVVLVVTRSESLVV 2421
            |.:|:|::.:...|::|..::|||.||::||.|::|..|..:::.|...:|....||
 Frog  2345 KSVTVHRVFAKAVASQDTMIEKGDGILSINGCSLQGAAHGYALNALHGAKPHRQAVV-------- 2401

  Fly  2422 KALTKKRSSLGSLSSLNEKPTELDYERKRNYHKASRSLDLDLDLVSNEAGESPVATTPSTGSVSP 2486
             .:.|:|.        .||.:.||..|.|  |..|              |:....|..:.|||
 Frog  2402 -VIQKERD--------GEKLSRLDASRGR--HTTS--------------GKDVSMTALAGGSV-- 2439

  Fly  2487 PQPASLHDEDAEATIAGIRARRQLSRGDAAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGG 2551
                     |...|:
 Frog  2440 ---------DLTDTM-------------------------------------------------- 2445

  Fly  2552 ARCVEIVKDSCGLGFSIEGGFDSPLGNRPLIVKKVFMGGAAQKTNQVRNGDEILSINGASTSRMT 2616
              |||:.|.|.|||||::||..|..|:|||.:|::|.||||::..:::.||||::|.|...:.:.
 Frog  2446 --CVELNKTSAGLGFSLDGGKASIYGDRPLFIKRIFKGGAAEQAGKIQAGDEIIAIGGKYLTGLM 2508

  Fly  2617 RVDAWNYMKQLPLGPVKI 2634
            ..||||.:|.:|.|||::
 Frog  2509 HYDAWNIIKAVPEGPVQL 2526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_648705.2	PDZ_canonical	90..177	CDD:467153
		PHA03247	<341..617	CDD:223021	47/219 (21%)
		PTZ00341	<926..1237	CDD:173534	76/383 (20%)
		PDZ6_PDZD2-PDZ3_hPro-IL-16-like	2330..2415	CDD:467243	29/84 (35%)
		PDZ7_PDZD2-PDZ4_hPro-IL-16-like	2552..2636	CDD:467244	38/83 (46%)
pdzd2	XP_031750652.1	PDZ1_PDZD2-like	86..179	CDD:467274
		PDZ2_PDZD2-like	303..390	CDD:467239	20/100 (20%)
		PDZ3_PDZD2-PDZ1_hPro-IL-16-like	563..648	CDD:467240	20/92 (22%)
		PDZ4_PDZD2-PDZ2_hPro-IL-16-like	701..790	CDD:467241	16/93 (17%)
		PDZ5_PDZD2-like	1142..1226	CDD:467242	18/86 (21%)
		PDZ6_PDZD2-PDZ3_hPro-IL-16-like	2319..2404	CDD:467243	29/94 (31%)
		PDZ7_PDZD2-PDZ4_hPro-IL-16-like	2444..2529	CDD:467244	39/135 (29%)