DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bbg and whrna

DIOPT Version :9

Sequence 1:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster
Sequence 2:	XP_002665968.3	Gene:	whrna / 100334777	ZFINID:	ZDB-GENE-091118-27	Length:	939	Species:	Danio rerio

Alignment Length:	1046	Identity:	200/1046 - (19%)
Similarity:	331/1046 - (31%)	Gaps:	355/1046 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1778 ISSSFTRKPLNRSSENLLDSCSSSSAPSLKTRAMSVEN-----LNDVQRQYQLAKQLPQLHVADS 1837
            :|:...|..||.||.|.:    :|||.||......:.|     |:|::|: |....|...|...:
Zfish     1 MSTDLERLSLNSSSGNSV----ASSARSLSANVKKLHNALNLLLSDLERE-QFIHCLNVYHSKRN 60

  Fly  1838 MYSLNTATPTPSYASLPRRSHGGSYSSGVERRISFSGEGGDAANRKAAITNILEQRRRSLSKLRG 1902
            :|                                      |.......|.|: ..:|:.|..||
Zfish    61 VY--------------------------------------DLVQTLKVILNV-PSKRQLLPMLR- 85

  Fly  1903 LVIPERPQLL------EPILDLPEIKSQVKAASGE-DSTDSGLGESHRSTVN-RNCQLGAGGAAN 1959
            ||||...|||      |.:.    :||::.|.:|: |....|...|.....| ...|:...|:.:
Zfish    86 LVIPRSDQLLFDQYTSEGLY----LKSEIHARNGDPDGAQEGANSSPTHGANFPASQVALRGSPD 146

  Fly  1960 NYRSILNTNQRRPLEQQLSQPPAKPPRTSLTPLQPRSMMIPPPPPPLDQ------ESDTDSVFS- 2017
            :..:                  :.....:|.||..|: .:|.||..:.|      :|:....||
Zfish   147 SIST------------------SSDGTATLIPLLGRN-FLPEPPGEIRQVILKRHKSNEGLGFSI 192

  Fly  2018 -----HTARV-ATPPEKFALTRTLSSETNTSIASSNTSTLTSGSSA-------GSQASC---SSL 2066
                 |...: .:..|..:|...........|...|.......:.|       ||:..|   .|:
Zfish   193 RGGSEHGVGIYVSLVEPGSLAEKEGLRMGDQIMKVNDKVFDRVTHADAVKVLKGSKKLCMSVRSV 257

  Fly  2067 GSTPAVDLTRRVLKSQVINGEAVALSSRKSILA---SAKCRSAKSRGQE-----EDNDS------ 2117
            |..|...:|..|.  ..::.:..::|....:||   ||..|.:.|:|:.     :|.|.
Zfish   258 GRIPGGYITNHVY--TWVDPQGRSVSPPPDLLAEHRSATLRRSNSQGRSHMQLLQDGDEKKVNLV 320

  Fly  2118 -TDGEACSLANRRMKPISSYKL--------QQQQIQLGKQLVVDKLINVAAYVELTSDTDD---- 2169
             .||.:..|   .::..:.|.|        :....:.|...|.|:::.|.....|:...|:
Zfish   321 LDDGRSLGL---MIRGGAEYSLGIYITGVDRGSAAECGGIKVGDQILEVNGRSFLSIPHDEAVRV 382

  Fly  2170 -------------------------------SSRRSDTPAKISAMFIDEERKAS-------FKGD 2196
                                           ||:.||:.|..|...|..::.||       :||.
Zfish   383 LKSSHHLMMTVKDVGRLPHTRTVVGETKWIASSQISDSSASSSVTGISLDQGASTSAKGGFYKGV 447

  Fly  2197 PNQQAKVKVEQVKPMVLPMLLPSAKREPLKQQTTAELREKFERSAAAQAQTQNHSPVIHKVTQKP 2261
            ...|..:                   ..|..|:.|.|.|        ||:        |.:|:..
Zfish   448 AGSQVTL-------------------SSLVNQSRAMLEE--------QAR--------HLLTEPE 477

  Fly  2262 HHERFSSLDSLASSSSGVSSTTQNVSTTQETATEFGSFSSLGSNQSLITAQDVQQIVEEADPPLK 2326
            .......:........||.   |.|....|.......||.|...:.::|.||    ||:.|.
Zfish   478 RQTMGYYIQEYRDGHVGVE---QLVMALFELFNTHAKFSLLSEVRGIVTPQD----VEKFDG--- 532

  Fly  2327 TPEAFIIVLQRENPESSIGITLAGGSDYEAKEITIH----------KILSNT---PAAKDGRLKK 2378
                  :||:||  ..::.....||:.::.....:.          ..::||   .|..||
Zfish   533 ------LVLRRE--IDALKARQGGGAGFQDSFSMVSYPDTLASSSASFMTNTTLSSARNDG---- 585

  Fly  2379 GDRILAVNGMSMRGLTHRESI----------------SVLKTPRPEVVLVVTRSESLVVKALTKK 2427
                :|.|......|.|..::                |....|.|.:....:|..:     |:|:
Zfish   586 ----VAENNGEQGSLEHSNALPDISLDEVHSTSDSPPSFKPPPPPGLQRRPSRKAT-----LSKR 641

  Fly  2428 RSSLGSLSSLNEKPTELDYERKRNYHKASRSL-----DLDLDLVSNE---AGESPVATTP----- 2479
            .||..|.|.|........:.|:..:.||.::.     .|.:|:.:::   ..:.|:...|
Zfish   642 PSSSSSQSGLYFTAPSRSHTRESKHPKAPKAFMSPPGTLKIDVPASQLSVVSQHPIGPFPRVQSP 706

  Fly  2480 -------STGSVSPPQP--------------------------------------ASLHDEDAEA 2499
                   |:..:.||.|                                      ..:|..:||.
Zfish   707 NKAKPAQSSSPIPPPAPNVPAPPGPPPPPPPPLPPPSCPDKPTPSSPASNQHFVMVEVHRPNAEP 771

  Fly  2500 TIAGIRARRQLSRGDAAKLSTS----------ELLERAAEARNAIAAEIRAQAEDAAASGGG--- 2551
            .:..:|...|:..|..::||.|          ::.|....:::......|.:|......||.
Zfish   772 DVNEVRPLPQVRGGTLSQLSDSGQTLSEDSGVDIPESGRLSKDTSPRPARTRAPRDGHGGGETSA 836

  Fly  2552 ---------ARCVEIVKDSCGLGFSIEGGFDS--PLGNRPLIVKKVFMGGAAQKTNQVRNGDEIL 2605
                     :..|.:.|.:..||.:||||.::  ||   |.|| .:..||:|....|::.|..||
Zfish   837 KPPGLLEPMSTLVRVAKSASTLGIAIEGGANTRQPL---PRIV-TIQRGGSAHNCGQLKVGQVIL 897

  Fly  2606 SINGAS 2611
            .:||.|
Zfish   898 EVNGVS 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	18/110 (16%)
		PDZ_signaling	2553..2634	CDD:238492	23/61 (38%)
whrna	XP_002665968.3	HN_L-whirlin_R1_like	25..102	CDD:259822	23/117 (20%)
		PDZ_signaling	174..255	CDD:238492	13/80 (16%)
		PDZ_signaling	314..394	CDD:238492	11/82 (13%)
		HN_L-whirlin_R2_like	459..538	CDD:259823	24/110 (22%)
		PDZ_signaling	848..919	CDD:238492	23/60 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900