DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13481 and RFWD3

DIOPT Version :9

Sequence 1:	NP_001097605.1	Gene:	CG13481 / 39579	FlyBaseID:	FBgn0036421	Length:	176	Species:	Drosophila melanogaster
Sequence 2:	NP_001357463.1	Gene:	RFWD3 / 55159	HGNCID:	25539	Length:	774	Species:	Homo sapiens

Alignment Length:	152	Identity:	45/152 - (29%)
Similarity:	74/152 - (48%)	Gaps:	36/152 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 FNSE-RTRILEQLQLNIF----GQISVEHHNAMNMSE--NLYELREGLDGLSRRME--------- 107
            ::|| |..:.|:||::..    ...|.|:...::.:|  ....|.|.|.|:|...|
Human   196 YDSETRNPVSEELQVSSSSDSDSDSSAEYGGVVDQAEESGAVILEEQLAGVSAEQEVTCIDGGKT 260

  Fly   108 -----------------SMQED--ITCSICLSPWSSNGRHRVVSLRCGHLFGNSCIRTAIR-RSH 152
                             ||.|:  .||:|||..|::.|.||:.:||||||||..||.|.:: :..
Human   261 LPKQPSPQKSEPLLPSASMDEEEGDTCTICLEQWTNAGDHRLSALRCGHLFGYRCISTWLKGQVR 325

  Fly   153 RCPICRRRALHADVRRIFSRRI 174
            :||.|.::|.|:|:..:::|.:
Human   326 KCPQCNKKARHSDIVVLYARTL 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13481	NP_001097605.1	zf-RING_2	114..158	CDD:290367	22/44 (50%)
RFWD3	NP_001357463.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..116
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..225		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..280		1/22 (5%)
		mRING-C3HGC3_RFWD3	283..331	CDD:319364	22/47 (47%)
		WD40	<486..774	CDD:225201
		WD 1	495..537
		WD40 repeat	500..537	CDD:293791
		WD 2	539..577
		WD40 repeat	543..580	CDD:293791
		WD 3	583..628
		WD40 repeat	588..655	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146167
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1451258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750