DRSC/TRiP Functional Genomics Resources

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Protein Alignment nuf and RAB11FIP4

DIOPT Version :10

Sequence 1:NP_001246751.1 Gene:nuf / 39572 FlyBaseID:FBgn0013718 Length:541 Species:Drosophila melanogaster
Sequence 2:NP_116321.2 Gene:RAB11FIP4 / 84440 HGNCID:30267 Length:637 Species:Homo sapiens


Alignment Length:537 Identity:136/537 - (25%)
Similarity:227/537 - (42%) Gaps:123/537 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 STDSLEDLNLSFNTSASQNPLSNAYSLGVTGGAGSDYCGFGK---HPP--------------ILI 109
            ||.|||.   |..:.|.::           ||.|..:....|   |.|              ::.
Human   161 STQSLEG---SVGSPAEKD-----------GGLGGLFLPEDKSLVHTPSMTTSDLSTHSTTSLIS 211

  Fly   110 DQETFLSLNPADFEDIVPSNSEPNSLVFIENKLETNNNSLESNNNHINNN------NNNKIYNLE 168
            ::|.|......|..|..||:..|:.        ||..|......:.::::      ....:||.|
Human   212 NEEQFEDYGEGDDVDCAPSSPCPDD--------ETRTNVYSDLGSSVSSSAGQTPRKMRHVYNSE 268

  Fly   169 NL---TSKFNNKTNNTNTNGFKLENLK-NFKNKLLCDFEDTNSGGGGGGGSGGSGPVGMMNGAL- 228
            .|   .|:...|.|..|....:|:||| |..|:.:       |....|.....|......||:. 
Human   269 LLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKI-------SSTAFGRQLMHSSNFSSSNGSTE 326

  Fly   229 -----SAEICDN-LNEQLELLQRKVDDLSDTQNIAEDRTTRTKTEYAVLQARYHMLEEQYRESEL 287
                 |.:.||| :.|::..|::||.:|.:......|..::.|.|...|..|.|.|||..::.|.
Human   327 DLFRDSIDSCDNDITEKVSFLEKKVTELENDSLTNGDLKSKLKQENTQLVHRVHELEEMVKDQET 391

  Fly   288 RAEERLAEEQKRHREILARVEREASLQNENCQMKIRATEIEATALREEAARLRVLCDKQANDLHR 352
            .||:.|.||.:||||...::|||.:.:.|....:::..|.|.|.||....||:...:|...:..|
Human   392 TAEQALEEEARRHREAYGKLEREKATEVELLNARVQQLEEENTELRTTVTRLKSQTEKLDEERQR 456

  Fly   353 TEEQLE----LARDQIGVLQQEHEEQAQALRRHEQEKKSTEELMLELGRELQ------------- 400
            ..::||    ..:|::.:.::..::..|.....::|:::|:||:.:|.:||:             
Human   457 MSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRKELEHLQMYKLDCERPG 521

  Fly   401 RARE------ESGARAMPTTSPESIRLEELHQELEEMRQKNRTLEEQNEELQATMLTNQATMLTN 459
            |.|.      |..|||         |..||..|::.::|:|..|.:||::               
Human   522 RGRSASSGLGEFNARA---------REVELEHEVKRLKQENYKLRDQNDD--------------- 562

  Fly   460 GVEQGRHLLNGTLNSLA-QELEEMSQAQDSVDSAT----LASLSQLQQAFQEKEDENVRLKHYID 519
                    |||.:.||: .|.:.:..||....|..    .||..:|.:|.:|:|:.|.||:.|:|
Human   563 --------LNGQILSLSLYEAKNLFAAQTKAQSLAAEIDTASRDELMEALKEQEEINFRLRQYMD 619

  Fly   520 TILLNIVENYPQLLEVK 536
            .|:|.|:::.|.:||:|
Human   620 KIILAILDHNPSILEIK 636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nufNP_001246751.1 COG4913 <238..>405 CDD:443941 50/189 (26%)
VirB5_like 436..>506 CDD:445702 16/74 (22%)
RBD-FIP 496..536 CDD:462805 16/39 (41%)
RAB11FIP4NP_116321.2 EF-hand_7 20..78 CDD:463900
Necessary for interaction with RAB11A, subcellular location, homo-or heterooligomerization 82..637 136/537 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..175 7/16 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 219..256 8/44 (18%)
SMC_prok_B <338..621 CDD:274008 84/314 (27%)
RBD-FIP 596..636 CDD:462805 16/39 (41%)
Blue background indicates that the domain is not in the aligned region.

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