DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nuf and rab11fip3

DIOPT Version :9

Sequence 1:	NP_001246751.1	Gene:	nuf / 39572	FlyBaseID:	FBgn0013718	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_005162938.1	Gene:	rab11fip3 / 573631	ZFINID:	ZDB-GENE-040724-138	Length:	1920	Species:	Danio rerio

Alignment Length:	519	Identity:	130/519 - (25%)
Similarity:	246/519 - (47%)	Gaps:	112/519 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 SASQNPLS-----NAYSLG----------VTGGAGSDYCGFGKH---PPILIDQETFLSLNP--- 119
            |..:|.|:     |.::||          |.||....:..||:.   ..:|:..:....:.|
Zfish  1456 SGIENTLTDGDDRNRFTLGSDLNGHTVVAVIGGEEEHFEDFGESNNTSDLLLANQEEGRVRPDGE 1520

  Fly   120 ADFEDIVPSNSE-PNSLVFI-----------ENKLETNNNSLESNNNHINNNNNNKIYNLENLTS 172
            .|.|.:..|:|. |:.|:.:           :|.|:  :.:||....|.    :.:|..||:|::
Zfish  1521 GDAEPLPHSDSPLPHPLMLLSPSPSSFPASFQNFLQ--SEALEFFCTHC----HKQISRLEDLST 1579

  Fly   173 KFNNKTNNTNTNGFKLENLKNFKNKLLCDFEDTNSGGGGGGGSGGSGPVGMMNGALSAEICD--- 234
            :.  :....|::..:|.:.|..::     .:.:|:             :.:| |.|:.:|.|
Zfish  1580 RL--QLLEMNSSSKRLSSKKAARH-----LQQSNN-------------LDVM-GDLTQDILDLAD 1623

  Fly   235 -NLNEQLELLQRKVDDLSDTQNIAEDRTTRTKTEYAVLQARYHMLEEQYRESELRAEERLAEEQK 298
             ::.:::.||:::|.:|......:|::..|.:.|...|..|.:.||||.:|.|||.||.|..:.:
Zfish  1624 RDITDKVLLLEKRVCELEKDSLESEEQHARLRQENLTLVHRANALEEQLKEQELRTEEDLLAQTR 1688

  Fly   299 RHREILARVEREASLQNENCQMKIRATEIEATALREEAARLRVLCDKQANDLHRTEEQLELARDQ 363
            :||:.|.:::||..|:.||.|.::...:.|.:.||.....||.       ::.|.||:....:|:
Zfish  1689 KHRDALNKLQRERDLEIENLQARLHQLDEENSELRSCVPCLRA-------NIERLEEEKRKLQDE 1746

  Fly   364 IGVLQQEHEEQAQALR---------RH--EQEKKSTEELMLELGRE---LQRAREESGARAMPTT 414
            ...:.|...|::::.|         ||  ::||:.|:.|:.:|.::   ||..:.|:.||...::
Zfish  1747 ADDITQRLNEESESRRKMSDKLSHERHTNQKEKECTQGLIEDLRKQLEHLQLFKLETEARRGRSS 1811

  Fly   415 S------PESIRLEELHQELEEMRQKNRTLEEQNEELQATMLTNQATMLTNGVEQGRHLLNGTLN 473
            |      ...:|..||.||:..::|.||:|:|||:||       ...::...::..:.|...:|:
Zfish  1812 SNGLQEYNTHMRENELEQEIRRLKQDNRSLKEQNDEL-------NGQIINLSIQGAKSLFTESLS 1869

  Fly   474 -SLAQELEEMSQAQDSVDSATLASLSQLQQAFQEKEDENVRLKHYIDTILLNIVENYPQLLEVK 536
             |||.|:..:|:|             :|.:|..::|:.|.||:.|||.|::.|:|:.|.:||||
Zfish  1870 ESLAAEINNVSRA-------------ELMEAIHKQEEINFRLQDYIDRIIVAIMESNPSILEVK 1920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nuf	NP_001246751.1	VirB5_like	436..>506	CDD:295212	17/70 (24%)
nuf	NP_001246751.1	RBD-FIP	496..536	CDD:255374	15/39 (38%)
rab11fip3	XP_005162938.1	EFh	1326..1383	CDD:238008
		EF-hand_7	1326..1382	CDD:290234
		BCAS2	<1650..1741	CDD:283380	32/97 (33%)
		SPEC	1661..1843	CDD:295325	56/188 (30%)
		YscO	1662..1798	CDD:284686	41/142 (29%)
		RBD-FIP	1880..1920	CDD:255374	17/52 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580392
Domainoid	1	1.000	97	1.000	Domainoid score	I7171
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419449at2759
OrthoFinder	1	1.000	-	-		FOG0002087
OrthoInspector	1	1.000	-	-		otm25927
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15726
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4084
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.980