DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nuf and Rab11fip4

DIOPT Version :9

Sequence 1:	NP_001246751.1	Gene:	nuf / 39572	FlyBaseID:	FBgn0013718	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001100493.1	Gene:	Rab11fip4 / 303337	RGDID:	1305063	Length:	637	Species:	Rattus norvegicus

Alignment Length:	469	Identity:	123/469 - (26%)
Similarity:	213/469 - (45%)	Gaps:	81/469 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 ILIDQETFLSLNPADFEDIVPSNSEPNSLVFIENKLETNNNSLESNNNHINNN------NNNKIY 165
            ::.::|.|......|..|..||:..|:.        ||..|......:.::::      .....|
  Rat   210 LISNEEQFEDYGEGDDVDCAPSSPCPDD--------ETRTNVYSDLGSSVSSSAGQTPRKMRHAY 266

  Fly   166 N---LENLTSKFNNKTNNTNTNGFKLENLK-NFKNKLLCDFEDTNSGGGGGGGSGGSGPVGMMNG 226
            |   |:...|:...|.|..|....:|:||| |..|:.:       |....|.....|......||
  Rat   267 NSDLLDVYCSQCCKKINLLNDLEARLKNLKANSPNRKI-------SSTAFGRQLMHSSNFSSSNG 324

  Fly   227 AL------SAEICDN-LNEQLELLQRKVDDLSDTQNIAEDRTTRTKTEYAVLQARYHMLEEQYRE 284
            :.      |.:.||| :.|::..|::||.:|.:....:....::.|.|...|..|.|.|||..::
  Rat   325 STEDLFRDSIDSCDNDITEKVSFLEKKVTELENDSLASGGLKSKLKLENVQLVHRVHELEEMVKD 389

  Fly   285 SELRAEERLAEEQKRHREILARVEREASLQNENCQMKIRATEIEATALREEAARLRVLCDKQAND 349
            .|..||:.|.||.:||||:..::|||.|.:.|....:::..|.|.|.||....||:...:|...:
  Rat   390 QETTAEQALEEEARRHREVYCKLEREKSTELELLNTRVQQLEEENTDLRTTVTRLKSQTEKLDEE 454

  Fly   350 LHRTEEQLE----LARDQIGVLQQEHEEQAQALRRHEQEKKSTEELMLELGRELQ---------- 400
            ..|..::||    ..:|::.:.::..::..|.....::|:::|:||:.:|.|||:
  Rat   455 RQRMSDRLEDTSLRLKDEMDLYKRMMDKLRQNRLEFQKEREATQELIEDLRRELEHLQMYKLDCE 519

  Fly   401 ---RAREESG-----ARAMPTTSPESIRLEELHQELEEMRQKNRTLEEQNEELQATMLTNQATML 457
               |.|..||     |||         |..||..|::.::|:|..|.:||::|...:|:..
  Rat   520 RPGRGRSSSGLGEFNARA---------REVELEHEVKRLKQENHKLRDQNDDLNGQILSLS---- 571

  Fly   458 TNGVEQGRHLLNGTLNSLAQELEEMSQAQDSVDSATLASLSQLQQAFQEKEDENVRLKHYIDTIL 522
                      |....|..|.:.:..|.|.: :|:   ||..:|.:|.:|:|:.|.||:.|:|.|:
  Rat   572 ----------LYEAKNLFATQTKAQSLAAE-IDT---ASRDELMEALKEQEEINFRLRQYMDKII 622

  Fly   523 LNIVENYPQLLEVK 536
            |.|:::.|.:||:|
  Rat   623 LAILDHNPSILEIK 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nuf	NP_001246751.1	VirB5_like	436..>506	CDD:295212	15/69 (22%)
nuf	NP_001246751.1	RBD-FIP	496..536	CDD:255374	16/39 (41%)
Rab11fip4	NP_001100493.1	EF-hand_7	21..78	CDD:290234
		GrpE	428..>512	CDD:295646	21/83 (25%)
		RBD-FIP	596..636	CDD:255374	16/39 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340594
Domainoid	1	1.000	103	1.000	Domainoid score	I6622
eggNOG	1	0.900	-	-		E1_KOG0982
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4553
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419449at2759
OrthoFinder	1	1.000	-	-		FOG0002087
OrthoInspector	1	1.000	-	-		otm45566
orthoMCL	1	0.900	-	-		OOG6_107919
Panther	1	1.100	-	-	O	PTHR15726
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.800