DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nuf and Rab11fip3

DIOPT Version :9

Sequence 1:	NP_001246751.1	Gene:	nuf / 39572	FlyBaseID:	FBgn0013718	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_220262.5	Gene:	Rab11fip3 / 303002	RGDID:	1308952	Length:	1110	Species:	Rattus norvegicus

Alignment Length:	329	Identity:	97/329 - (29%)
Similarity:	169/329 - (51%)	Gaps:	58/329 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 DNLNEQLELLQRKVDDLSDTQNIAEDRTTRTKTEYAVLQARYHMLEEQYRESELRAEERLAEEQK 298
            :::.:::..|:|:|.:|......|.::..|.:.|...|..|.:.||||.:|.|.||:|::.||.:
  Rat   814 EDIADKVIFLERRVSELEKDSAAAGEQHGRLRQENLQLVHRANALEEQLKEQEFRAQEKVLEETR 878

  Fly   299 RHREILARVEREASLQNENCQMKIRATEIEATALREEAARLRVLCDKQANDLHRTEEQLELARDQ 363
            :.:|:|.::|||.|::.||.|.:::..:.|.:.||.....|:.       ::.|.||:.:...|:
  Rat   879 KQKELLCKMEREKSIEIENLQARLQQLDEENSELRSCTPCLKA-------NIERLEEEKQKMLDE 936

  Fly   364 IGVLQQEHEEQAQALR---------RH--EQEKKSTEELMLELGRELQ------------RAREE 405
            |..|.|...|:.:..|         ||  :::|::|:||:.:|.::|:            |.|..
  Rat   937 IEELTQRLSEEQENKRKMGDKLSHERHQFQRDKEATQELIEDLRKQLEHLQLLRLEMEQRRGRSS 1001

  Fly   406 S-GARAMPTTSPESIRLEELHQELEEMRQKNRTLEEQNEELQATMLTNQATMLTNGVEQGRHLLN 469
            | |.:...:.:.||    ||.||:..::|.||.|:|||:||...::|...        ||...|.
  Rat  1002 SLGLQEYNSRARES----ELEQEVRRLKQDNRNLKEQNDELNGQIITLSI--------QGAKSLF 1054

  Fly   470 GT--LNSLAQELEEMSQAQDSVDSATLASLSQLQQAFQEKEDENVRLKHYIDTILLNIVENYPQL 532
            .|  ..|||.|:..:|:             .:|.:|.|::|:.|.||:.|||.|::.|:|..|.:
  Rat  1055 STSFSESLAAEISSVSR-------------DELMEAIQKQEEINFRLQDYIDRIIVAILETNPSI 1106

  Fly   533 LEVK 536
            ||||
  Rat  1107 LEVK 1110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nuf	NP_001246751.1	VirB5_like	436..>506	CDD:295212	19/71 (27%)
nuf	NP_001246751.1	RBD-FIP	496..536	CDD:255374	16/39 (41%)
Rab11fip3	XP_220262.5	EFh	516..573	CDD:238008
		EF-hand_7	517..573	CDD:290234
		BCAS2	<833..943	CDD:283380	35/116 (30%)
		TPR_MLP1_2	894..1042	CDD:285204	43/158 (27%)
		SynN	894..996	CDD:294095	24/108 (22%)
		WD40_alt	1001..1044	CDD:290784	17/46 (37%)
		RBD-FIP	1070..1110	CDD:255374	17/52 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I6622
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4553
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419449at2759
OrthoFinder	1	1.000	-	-		FOG0002087
OrthoInspector	1	1.000	-	-		otm45566
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15726
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.070