DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nuf and Rab11fip3

DIOPT Version :9

Sequence 1:	NP_001246751.1	Gene:	nuf / 39572	FlyBaseID:	FBgn0013718	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	XP_036016358.1	Gene:	Rab11fip3 / 215445	MGIID:	2444431	Length:	1118	Species:	Mus musculus

Alignment Length:	320	Identity:	97/320 - (30%)
Similarity:	163/320 - (50%)	Gaps:	58/320 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 LQRKVDDLSDTQNIAEDRTTRTKTEYAVLQARYHMLEEQYRESELRAEERLAEEQKRHREILARV 307
            |:|:|.:|......|.::..|.:.|...|..|.:.||||.:|.|.||:|::.||.::.:|:|.::
Mouse   831 LERRVSELEKDSAAAGEQHGRLRQENLQLVHRANALEEQLKEQEFRAQEKVLEETRKQKELLCKM 895

  Fly   308 EREASLQNENCQMKIRATEIEATALREEAARLRVLCDKQANDLHRTEEQLELARDQIGVLQQEHE 372
            |||.|::.||.|.:::..:.|.:.||.....|:.       ::.|.||:.:...|:|..|.|...
Mouse   896 EREKSIEIENLQARLQQLDEENSELRSCTPCLKA-------NIERLEEEKQKMLDEIEELTQRLS 953

  Fly   373 EQAQALR---------RH--EQEKKSTEELMLELGRELQ------------RAREES-GARAMPT 413
            |:.:..|         ||  :::|::|:||:.:|.::|:            |.|..| |.:...:
Mouse   954 EEQENKRKMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLRLEVEQRRGRSSSLGLQEYNS 1018

  Fly   414 TSPESIRLEELHQELEEMRQKNRTLEEQNEELQATMLTNQATMLTNGVEQGRHLLNGT--LNSLA 476
            .:.||    ||.||:..::|.||.|:|||:||...::|...        ||...|..|  ..|||
Mouse  1019 RARES----ELEQEVRRLKQDNRNLKEQNDELNGQIITLSI--------QGAKSLFSTSFSESLA 1071

  Fly   477 QELEEMSQAQDSVDSATLASLSQLQQAFQEKEDENVRLKHYIDTILLNIVENYPQLLEVK 536
            .|:..:|:             .:|.:|.|::|:.|.||:.|||.|::.|:|..|.:||||
Mouse  1072 AEISSVSR-------------DELMEAIQKQEEINFRLQDYIDRIIVAILETNPSILEVK 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nuf	NP_001246751.1	VirB5_like	436..>506	CDD:295212	19/71 (27%)
nuf	NP_001246751.1	RBD-FIP	496..536	CDD:255374	16/39 (41%)
Rab11fip3	XP_036016358.1	PTZ00449	<12..331	CDD:185628
		EF-hand_7	500..557	CDD:404394
		Smc	<853..1116	CDD:224117	87/294 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836879
Domainoid	1	1.000	105	1.000	Domainoid score	I6651
eggNOG	1	0.900	-	-		E1_KOG0982
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4611
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419449at2759
OrthoFinder	1	1.000	-	-		FOG0002087
OrthoInspector	1	1.000	-	-		otm43504
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15726
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4084
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.930