DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nan and Trpv4

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_076460.1	Gene:	Trpv4 / 66026	RGDID:	69337	Length:	871	Species:	Rattus norvegicus

Alignment Length:	686	Identity:	167/686 - (24%)
Similarity:	275/686 - (40%)	Gaps:	199/686 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 AVGETILHLCLLNASS-------LHADLAKR---LLKFYPKLILDIYMSDEYYGESVLHIAIVNE 191
            :.|:|.|...|||.|:       :..|:|:|   :.:|......|||    |.|::.|||||...
  Rat   189 STGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIY----YRGQTALHIAIERR 249

  Fly   192 DPAMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAA 256
            ....|:.|:...|||..:..|.|...:|.                     .||.|:||.|||.||
  Rat   250 CKHYVELLVAQGADVHAQARGRFFQPKDE---------------------GGYFYFGELPLSLAA 293

  Fly   257 CLSQEECFRLVLA---RGADPDFQDTNGNTVLHMLVIY-----EKIEMFDVGYEV---------- 303
            |.:|......:..   :.||...||:.||||||.||..     |..:.....|::
  Rat   294 CTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFP 358

  Fly   304 GTNIH-IKNIQNLTPLTLAAKLGRVEMFFHVMSIEREIY-------------WQLGSITCAAYPL 354
            .:|:. :.|...|:||.:|||.|::.:|.|:  |.||:.             |..|.:..:.|.|
  Rat   359 DSNLETVLNNDGLSPLMMAAKTGKIGVFQHI--IRREVTDEDTRHLSRKFKDWAYGPVYSSLYDL 421

  Fly   355 LMIDTINEETGNINKDSVLNFVVFGDKLE--HLELLDGVVIDLLKTKWDTFCKSRFYKQFYMFAL 417
            ..:||..||.      |||..:|:..|:|  |..|....:.:||:.||..|..    ..||:..:
  Rat   422 SSLDTCGEEV------SVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGA----VSFYINVV 476

  Fly   418 YFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLNFTE 482
            .:|.::..|.|                                                    |.
  Rat   477 SYLCAMVIFTL----------------------------------------------------TA 489

  Fly   483 YYDPSEVEVLPAWWESYAQCPLMNLESDLAKLRIMAELLNFVGAILYLLVALREARFLGLK---- 543
            ||.|.|            ..|.....:.:..||:..|::..:..:|:...::::   |.:|
  Rat   490 YYQPLE------------GTPPYPYRTTVDYLRLAGEVITLLTGVLFFFTSIKD---LFMKKCPG 539

  Fly   544 ---MFIE---NLMTAPSRVMFLFSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYF--LFFCR 600
               :|::   .|:.....|:.:.|.||.          |..|:.::.|::......:.  |:|.|
  Rat   540 VNSLFVDGSFQLLYFIYSVLVVVSAALY----------LAGIEAYLAVMVFALVLGWMNALYFTR 594

  Fly   601 GFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDN-------------PSSPE 652
            |.|..|.:.:||.:::..||.||:.:||:|::|::.|...:.....|             ||.|.
  Rat   595 GLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVTLLNPCTNMKVCNEDQSNCTVPSYPA 659

  Fly   653 DQDAESNPMPSPMESIVAMFLMSL----TNFGDYYGAMVSTQHEYEAKILFFLFMVIVSVLLVNM 713
            .:|:|:          .:.||:.|    ...|| ...:.|.::.....:|...::::..|||:||
  Rat   660 CRDSET----------FSAFLLDLFKLTIGMGD-LEMLSSAKYPVVFILLLVTYIILTFVLLLNM 713

  Fly   714 LIAMMGNTYQKIA-EIRNEWQRQWARIVLVVERSVP 748
            |||:||.|..::: |.::.|:.|||..:|.:|||.|
  Rat   714 LIALMGETVGQVSKESKHIWKLQWATTILDIERSFP 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	26/81 (32%)
		ANK	<131..200	CDD:238125	22/72 (31%)
		ANK repeat	138..174	CDD:293786	13/45 (29%)
		ANK	178..329	CDD:238125	50/169 (30%)
		ANK repeat	179..229	CDD:293786	14/49 (29%)
		Ank_2	184..311	CDD:289560	40/145 (28%)
		ANK repeat	231..278	CDD:293786	14/49 (29%)
		ANK repeat	280..311	CDD:293786	11/46 (24%)
		Ion_trans	519..727	CDD:278921	54/237 (23%)
Trpv4	NP_076460.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		TRPV4	103..834	CDD:411979	167/686 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..143
		ANK repeat	191..231	CDD:293786	11/39 (28%)
		ANK repeat	237..268	CDD:293786	11/30 (37%)
		ANK 1	237..266		11/28 (39%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:A0A1D5PXA5	249..251		0/1 (0%)
		ANK repeat	284..318	CDD:293786	11/33 (33%)
		ANK 2	284..313		9/28 (32%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:A0A1D5PXA5	296..299		1/2 (50%)
		ANK 3	369..398		12/30 (40%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:O35433	679..682		0/2 (0%)
		Interaction with calmodulin and ITPR3. /evidence=ECO:0000250\|UniProtKB:Q9HBA0	812..831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338796
Domainoid	1	1.000	75	1.000	Domainoid score	I8820
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8914
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.810