DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nan and Trpv4

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_071300.2	Gene:	Trpv4 / 63873	MGIID:	1926945	Length:	871	Species:	Mus musculus

Alignment Length:	677	Identity:	169/677 - (24%)
Similarity:	278/677 - (41%)	Gaps:	181/677 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 AVGETILHLCLLNASS-------LHADLAKR---LLKFYPKLILDIYMSDEYYGESVLHIAIVNE 191
            :.|:|.|...|||.|:       :..|:|:|   :.:|......|||    |.|::.|||||...
Mouse   189 STGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIY----YRGQTSLHIAIERR 249

  Fly   192 DPAMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAA 256
            ....|:.|:...|||..:..|.|...:|.                     .||.|:||.|||.||
Mouse   250 CKHYVELLVAQGADVHAQARGRFFQPKDE---------------------GGYFYFGELPLSLAA 293

  Fly   257 CLSQEECFRLVLA---RGADPDFQDTNGNTVLHMLVIY-----EKIEMFDVGYEV---------- 303
            |.:|......:..   :.||...||:.||||||.||..     |..:.....|::
Mouse   294 CTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCSRLFP 358

  Fly   304 GTNIH-IKNIQNLTPLTLAAKLGRVEMFFHVMSIEREIY-------------WQLGSITCAAYPL 354
            .:|:. :.|...|:||.:|||.|::.:|.|:  |.||:.             |..|.:..:.|.|
Mouse   359 DSNLETVLNNDGLSPLMMAAKTGKIGVFQHI--IRREVTDEDTRHLSRKFKDWAYGPVYSSLYDL 421

  Fly   355 LMIDTINEETGNINKDSVLNFVVFGDKLE--HLELLDGVVIDLLKTKWDTFCKSRFYKQFYMFAL 417
            ..:||..||.      |||..:|:..|:|  |..|....:.:||:.||..|..    ..||:..:
Mouse   422 SSLDTCGEEV------SVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGA----VSFYINVV 476

  Fly   418 YFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLNFTE 482
            .:|.::..|.|                                                    |.
Mouse   477 SYLCAMVIFTL----------------------------------------------------TA 489

  Fly   483 YYDPSEVEVLPAWWESYAQCPLMNLESDLAKLRIMAELLNFVGAILYLLVALRE---ARFLGL-K 543
            ||.|.|            ..|.....:.:..||:..|::.....:|:...::::   .:..|: .
Mouse   490 YYQPLE------------GTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTSIKDLFTKKCPGVNS 542

  Fly   544 MFIE---NLMTAPSRVMFLFSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYF--LFFCRGFK 603
            :|::   .|:.....|:.:.|.||.          |..|:.::.|::......:.  |:|.||.|
Mouse   543 LFVDGSFQLLYFIYSVLVVVSAALY----------LAGIEAYLAVMVFALVLGWMNALYFTRGLK 597

  Fly   604 TVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSS-----PEDQDAESNP-MP 662
            ..|.:.:||.:::..||.||:.:||:|::|::.|    .:|..||.:     .|||...:.| .|
Mouse   598 LTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASA----LVTLLNPCTNMKVCDEDQSNCTVPTYP 658

  Fly   663 SPMES-IVAMFLMSL----TNFGDYYGAMVSTQHEYEAKILFFLFMVIVSVLLVNMLIAMMGNTY 722
            :..:| ..:.||:.|    ...|| ...:.|.::.....:|...::::..|||:|||||:||.|.
Mouse   659 ACRDSETFSAFLLDLFKLTIGMGD-LEMLSSAKYPVVFILLLVTYIILTFVLLLNMLIALMGETV 722

  Fly   723 QKIA-EIRNEWQRQWARIVLVVERSVP 748
            .::: |.::.|:.|||..:|.:|||.|
Mouse   723 GQVSKESKHIWKLQWATTILDIERSFP 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	26/81 (32%)
		ANK	<131..200	CDD:238125	22/72 (31%)
		ANK repeat	138..174	CDD:293786	13/45 (29%)
		ANK	178..329	CDD:238125	50/169 (30%)
		ANK repeat	179..229	CDD:293786	14/49 (29%)
		Ank_2	184..311	CDD:289560	40/145 (28%)
		ANK repeat	231..278	CDD:293786	14/49 (29%)
		ANK repeat	280..311	CDD:293786	11/46 (24%)
		Ion_trans	519..727	CDD:278921	56/228 (25%)
Trpv4	NP_071300.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..143
		trp	149..803	CDD:273311	169/677 (25%)
		ANK repeat	191..231	CDD:293786	11/39 (28%)
		ANK repeat	237..268	CDD:293786	11/30 (37%)
		ANK 1	237..266		11/28 (39%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:A0A1D5PXA5	249..251		0/1 (0%)
		ANK repeat	284..318	CDD:293786	11/33 (33%)
		ANK 2	284..313		9/28 (32%)
		Phosphatidylinositol 4,5-bisphosphate binding. /evidence=ECO:0000250\|UniProtKB:A0A1D5PXA5	296..299		1/2 (50%)
		ANK 3	369..398		12/30 (40%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:12093812	679..682		0/2 (0%)
		Interaction with calmodulin and ITPR3. /evidence=ECO:0000250\|UniProtKB:Q9HBA0	812..831
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835195
Domainoid	1	1.000	76	1.000	Domainoid score	I8918
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8679
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4284
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.830