DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nan and TRPV4

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_011536932.2	Gene:	TRPV4 / 59341	HGNCID:	18083	Length:	922	Species:	Homo sapiens

Alignment Length:	681	Identity:	174/681 - (25%)
Similarity:	276/681 - (40%)	Gaps:	189/681 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 AVGETILHLCLLNASS-------LHADLAKR---LLKFYPKLILDIYMSDEYYGESVLHIAIVNE 191
            :.|:|.|...|||.|:       :..|:|:|   :.:|......|||    |.|::.|||||...
Human   240 STGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIY----YRGQTALHIAIERR 300

  Fly   192 DPAMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAA 256
            ....|:.|:...|||..:..|.|...:|.                     .||.|:||.|||.||
Human   301 CKHYVELLVAQGADVHAQARGRFFQPKDE---------------------GGYFYFGELPLSLAA 344

  Fly   257 CLSQEECFRLVLA---RGADPDFQDTNGNTVLHMLVIY-----EKIEMFDVGYEV---------- 303
            |.:|......:..   :.||...||:.||||||.||..     |..:.....|::
Human   345 CTNQPHIVNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFP 409

  Fly   304 GTNIH-IKNIQNLTPLTLAAKLGRVEMFFHVMSIEREIY-------------WQLGSITCAAYPL 354
            .:|:. :.|...|:||.:|||.|::.:|.|:  |.||:.             |..|.:..:.|.|
Human   410 DSNLEAVLNNDGLSPLMMAAKTGKIGIFQHI--IRREVTDEDTRHLSRKFKDWAYGPVYSSLYDL 472

  Fly   355 LMIDTINEETGNINKDSVLNFVVFGDKLE--HLELLDGVVIDLLKTKWDTFCKSRFYKQFYMFAL 417
            ..:||..||.      |||..:|:..|:|  |..|....:.:||:.||..|..    ..||:..:
Human   473 SSLDTCGEEA------SVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGA----VSFYINVV 527

  Fly   418 YFLISLFSFILR----------PGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTE 472
            .:|.::..|.|.          |.|                   ||.. .|...|..:..|:.|.
Human   528 SYLCAMVIFTLTAYYQPLEGTPPYP-------------------YRTT-VDYLRLAGEVITLFTG 572

  Fly   473 YKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMN---LESDLAKLRIMAELLNFVGAILYLLVAL 534
            ...|:.|..:.:              ..:||.:|   ::.....|..:..:|..|.|.|||
Human   573 VLFFFTNIKDLF--------------MKKCPGVNSLFIDGSFQLLYFIYSVLVIVSAALYL---- 619

  Fly   535 REARFLGLKMFIENLMTAPSRVMFLFSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYFLFFC 599
                 .|::.::..::.|             :.:.|:..                      |:|.
Human   620 -----AGIEAYLAVMVFA-------------LVLGWMNA----------------------LYFT 644

  Fly   600 RGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSS-----PEDQDAESN 659
            ||.|..|.:.:||.:::..||.||:.:||:|::|::.|...:.    ||.:     .|||...:.
Human   645 RGLKLTGTYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLL----NPCANMKVCNEDQTNCTV 705

  Fly   660 P-MPSPMES-IVAMFLMSL----TNFGDYYGAMVSTQHEYEAKILFFLFMVIVSVLLVNMLIAMM 718
            | .||..:| ..:.||:.|    ...|| ...:.||::.....||...::::..|||:|||||:|
Human   706 PTYPSCRDSETFSTFLLDLFKLTIGMGD-LEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALM 769

  Fly   719 GNTYQKIA-EIRNEWQRQWARIVLVVERSVP 748
            |.|..::: |.::.|:.|||..:|.:|||.|
Human   770 GETVGQVSKESKHIWKLQWATTILDIERSFP 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	26/81 (32%)
		ANK	<131..200	CDD:238125	22/72 (31%)
		ANK repeat	138..174	CDD:293786	13/45 (29%)
		ANK	178..329	CDD:238125	50/169 (30%)
		ANK repeat	179..229	CDD:293786	14/49 (29%)
		Ank_2	184..311	CDD:289560	40/145 (28%)
		ANK repeat	231..278	CDD:293786	14/49 (29%)
		ANK repeat	280..311	CDD:293786	11/46 (24%)
		Ion_trans	519..727	CDD:278921	55/219 (25%)
TRPV4	XP_011536932.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145087
Domainoid	1	1.000	75	1.000	Domainoid score	I9056
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4284
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.980