DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nan and trpv1

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_005165384.1	Gene:	trpv1 / 561195	ZFINID:	ZDB-GENE-030912-8	Length:	819	Species:	Danio rerio

Alignment Length:	839	Identity:	181/839 - (21%)
Similarity:	320/839 - (38%)	Gaps:	277/839 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 IHDY----CPEVSEAEYISNPTAYRFVCWDLNMRGAVGETILHLCLLNASSLHADLAKRLLKFYP 166
            :|:|    ...:::::|.||                 |:|.|...|||......|..::||....
Zfish   100 LHEYLHKNMKRLTDSQYKSN-----------------GKTALLKALLNLRQGENDTIEQLLDIAE 147

  Fly   167 KL-----ILDIYMSDEYY-GESVLHIAIVNEDPAMVKYLLDANADVQERCCGAFMSAEDTKFSRT 225
            |:     .::...:|.|| |::.||:||.......|:.|:...|||..:.||.|.
Zfish   148 KMGDLKNFINAAYTDSYYKGQTALHVAIERRSMKFVQMLVKKGADVHAKACGKFF---------- 202

  Fly   226 DSPDHEYVALCPMTNYDGYVYWGEYPLSFAACLSQEECFRLVLA---RGADPDFQDTNGNTVLHM 287
             .|:.:   :|        .|:||.|||.|||.:|::....::.   :..|...:|.:||||||.
Zfish   203 -QPNQK---MC--------FYFGELPLSLAACTNQQDIVDFLMENPHQAVDVRERDCHGNTVLHA 255

  Fly   288 LVIYEK---------IEMFDVGYEVGTNIH-------IKNIQNLTPLTLAAKLGRVEMFFHVMSI 336
            ||....         |.|:|........:|       |:|.:.|||:|||||.|::.:|.|:  :
Zfish   256 LVSVADNSPENTEFVIAMYDHILIKADQLHPKTKLEEIENNEGLTPITLAAKKGKLGLFKHI--V 318

  Fly   337 EREIY-----------WQLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVFGDKL-EHLELLD 389
            :||:.           |..|.:..:.|.|..:||       ..|:|.|..||:|.:: ..||:|.
Zfish   319 QRELMGCRHLSRKITEWAYGPVCSSLYDLSSLDT-------YEKNSALEIVVYGSEIPNRLEMLQ 376

  Fly   390 GVVID-LLKTKWDTFCKSRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYR 453
            ...:: |::.|||.|....|...|.::.:|    ||.|                   || |..|.
Zfish   377 IEPLNRLIEEKWDQFAHRMFLFNFIVYVIY----LFIF-------------------TA-SAFYH 417

  Fly   454 QNGSDSYHLHSKRATMTTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNLESDLAKLRIMA 518
            :.|.|                                     :.:..:.|.:..:|....|.:..
Zfish   418 EEGKD-------------------------------------YANQTKPPYLYAKSREGYLLLTG 445

  Fly   519 ELLNFVGAILYLLVAL-----REARFLGL--------KMFIENLMTAPSRVMFLFS-------CA 563
            .:::..||..:.:..|     :..||..|        ..|::.|:...|.|::.:.       ..
Zfish   446 HIISITGAFYFFIRGLIDMVRKRPRFQSLIIDGYTDQLFFVQGLLFLASVVLYCYGQYEYLAFLV 510

  Fly   564 LMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYFLFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYL 628
            |.:.:.|:.:                      |:|.||.|.:|.:.|||.:||:|::.||:.:|:
Zfish   511 LCLALSWINL----------------------LYFSRGSKNLGIYNVMIQKMVLGEIRRFLVVYM 553

  Fly   629 VFVMGFSQAFYIIF--------------LTFDNPSSPEDQDAESNPM------------------ 661
            ||::|||.|...:.              |:.|.||.....|: |||.
Zfish   554 VFLIGFSAALVTLLDQESIDSGSTRDFRLSEDIPSLNPTPDS-SNPQSRMTHHQPTTARDGRGRF 617

  Fly   662 -----------PSPMESIVAMFLMSLTNFGDYYGAMVSTQHEYEAK----ILFFLFMVIVSVLLV 711
                       ..|....:....:.|..|....|.:..|.| |:.|    :|..:::|:..:|::
Zfish   618 GLTTDNQYEVCKKPSYKNIYFTTLELFKFTIGMGDLEFTDH-YKYKEVFYVLLIVYIVMTYILML 681

  Fly   712 NMLIAMMGNTYQKIA-EIRNEWQRQWARIVLVVERSVPPAERLK--------------------- 754
            |||||:|..:.:.:: |..:.|:.|.|...|.:|..:|...:.|
Zfish   682 NMLIALMNQSVEMMSVESTSIWKLQRAITTLDMEWILPKCLQGKLRSGEEKDLGGGQEPDRRWCF 746

  Fly   755 -----NFMQYSQSMSDGRRALVLRLN---MTEEEKEEMKEVQEMKRIHQRFAKKRQMER 805
                 |:.|::::|     .:::..:   .|::......:.:..:.:.|.|:::|:.:|
Zfish   747 SVEEVNWTQWNRNM-----GIIINEDPGKCTQDPSPANVQREPSRGVLQTFSRRRRTQR 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	23/83 (28%)
		ANK	<131..200	CDD:238125	19/74 (26%)
		ANK repeat	138..174	CDD:293786	10/40 (25%)
		ANK	178..329	CDD:238125	52/170 (31%)
		ANK repeat	179..229	CDD:293786	14/50 (28%)
		Ank_2	184..311	CDD:289560	39/145 (27%)
		ANK repeat	231..278	CDD:293786	12/49 (24%)
		ANK repeat	280..311	CDD:293786	13/46 (28%)
		Ion_trans	519..727	CDD:278921	58/275 (21%)
trpv1	XP_005165384.1	ANK	74..187	CDD:238125	24/103 (23%)
		Ank_2	85..196	CDD:289560	28/112 (25%)
		ANK repeat	119..162	CDD:293786	11/59 (19%)
		ANK	165..318	CDD:238125	53/176 (30%)
		ANK repeat	167..197	CDD:293786	10/29 (34%)
		ANK repeat	212..246	CDD:293786	10/33 (30%)
		Ank_2	217..321	CDD:289560	33/105 (31%)
		Ion_trans	<485..689	CDD:278921	51/227 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578397
Domainoid	1	1.000	81	1.000	Domainoid score	I8466
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48943
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6594
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4284
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.990