DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nan and trpv4

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_005165208.1	Gene:	trpv4 / 557850	ZFINID:	ZDB-GENE-030912-7	Length:	859	Species:	Danio rerio

Alignment Length:	680	Identity:	176/680 - (25%)
Similarity:	279/680 - (41%)	Gaps:	191/680 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 AVGETILHLCLLNASSLH----------ADLAKR---LLKFYPKLILDIYMSDEYYGESVLHIAI 188
            :.|:|.|...|||   ||          .|:|::   |.:|......|:|    |.|:..|||||
Zfish   199 STGKTCLPKALLN---LHNGQNDTIPILVDIAEQTGNLREFINTPFRDVY----YRGQMALHIAI 256

  Fly   189 VNEDPAMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLS 253
            .......|:.|::..|||..:..|.|....|.                     .||.|:||.|||
Zfish   257 ERRCKQYVELLVEKGADVHAQARGRFFQPRDE---------------------GGYFYFGELPLS 300

  Fly   254 FAACLSQEECFRLVLARG---ADPDFQDTNGNTVLHMLV-IYEK--------IEMFDV----GYE 302
            .|||.:|.:....:...|   ||...||:.||||||.|| |.:.        .:|||:    ..:
Zfish   301 LAACTNQPDMVHYLTENGHKKADLRRQDSRGNTVLHALVHIADNTRDNTRFVTKMFDLLLIKCAK 365

  Fly   303 VGTNIHIKNIQN---LTPLTLAAKLGRVEMFFHVMSIEREIY-------------WQLGSITCAA 351
            :..:.:::||.|   ::||.:|||||::.:|.|:  |.|||.             |..|.:....
Zfish   366 LYPDCNLENILNNDGMSPLMMAAKLGKIGVFQHI--IRREIKDEEARHLSRKFKDWAYGPVYSNL 428

  Fly   352 YPLLMIDTINEETGNINKDSVLNFVVFGDKLE--HLELLDGVVIDLLKTKWDTFCKSRFYKQFYM 414
            |.|..:||..||.      |||..:|:..|:|  |..|....:.:||:.||..|....||...:.
Zfish   429 YDLSSLDTCGEEV------SVLEILVYNSKIENRHEMLAVEPINELLRAKWQKFAAVTFYISVFS 487

  Fly   415 FALYFLISLFSFILRPG----PDAKDEDED----GANSTTAKSDLYRQNGSDSYHLHSKRATMTT 471
            :.:..:|.......||.    |.|.|..||    .....|..|.|:               ...|
Zfish   488 YLVTMIIFTLVAYYRPSVGKPPYAYDTTEDKVRLAGEIITVGSGLF---------------FFVT 537

  Fly   472 EYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMN---LESDLAKLRIMAELLNFVGAILYLLVA 533
            ..|..:|.                     :||.:|   ::.....|..:..:|..|.|.|||
Zfish   538 NIKDLFLK---------------------KCPGVNSIFVDGSFQLLYFIYSVLVLVSAALYL--- 578

  Fly   534 LREARFLGLKMFIENLMTAPSRVMFLFSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYFLFF 598
                  .|::.::..::.|             :|:.|:..                      |:|
Zfish   579 ------SGIEAYVSVMVFA-------------LTLGWMNT----------------------LYF 602

  Fly   599 CRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTF--------DN-PSSPEDQ 654
            .||.|..|.:.:||.::::.||.||:.:|::|::|::.|. :..||.        :| |:.||.:
Zfish   603 TRGLKLTGTYSIMIQKILIKDLFRFLLVYVLFMIGYASAL-VSLLTICPDKDTCKENCPTYPECR 666

  Fly   655 DAESNPMPSPMESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILFFLFMVIVSVLLVNMLIAMMG 719
            |..:.     .|.::.:|.::: ..||....:...|:.....||...::::..|||:|||||:||
Zfish   667 DTNTF-----SEFLLDLFKLTI-GIGDLDNMLKGAQYPAVFLILLVTYIILTFVLLLNMLIALMG 725

  Fly   720 NTYQKIA-EIRNEWQRQWARIVLVVERSVP 748
            .|..::: |.:..|:.|||..:|.:|||.|
Zfish   726 ETVGQVSKESKKIWKLQWATTILDIERSFP 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	26/84 (31%)
		ANK	<131..200	CDD:238125	22/75 (29%)
		ANK repeat	138..174	CDD:293786	13/48 (27%)
		ANK	178..329	CDD:238125	54/169 (32%)
		ANK repeat	179..229	CDD:293786	14/49 (29%)
		Ank_2	184..311	CDD:289560	42/142 (30%)
		ANK repeat	231..278	CDD:293786	15/49 (31%)
		ANK repeat	280..311	CDD:293786	12/43 (28%)
		Ion_trans	519..727	CDD:278921	51/217 (24%)
trpv4	XP_005165208.1	trp	159..857	CDD:273311	176/680 (26%)
		ANK repeat	247..278	CDD:293786	11/30 (37%)
		ANK	248..400	CDD:238125	55/174 (32%)
		ANK repeat	294..328	CDD:293786	12/33 (36%)
		ANK repeat	330..364	CDD:293786	12/33 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578398
Domainoid	1	1.000	73	1.000	Domainoid score	I9182
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4007
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6594
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4284
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.890