DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nan and TRPV6

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_061116.5	Gene:	TRPV6 / 55503	HGNCID:	14006	Length:	765	Species:	Homo sapiens

Alignment Length:	690	Identity:	187/690 - (27%)
Similarity:	318/690 - (46%)	Gaps:	134/690 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 LNMRGAVGETILHLCLLNASSLHADLAKRLLKFYPKLILDIYMSDEYYGESVLHIAIVNEDPAMV 196
            ::.|||:|||.||:..| ..:|.|  |..|::..|:|:.:...|:.|.|::.||||:||::..:|
Human   112 VHQRGAMGETALHIAAL-YDNLEA--AMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLV 173

  Fly   197 KYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACLSQE 261
            :.||...|.|..|..|       |.|.|  ||       |.:      :|:||:|||||||::.|
Human   174 RALLARRASVSARATG-------TAFRR--SP-------CNL------IYFGEHPLSFAACVNSE 216

  Fly   262 ECFRLVLARGADPDFQDTNGNTVLHMLVI----------YEKIEMFDVGYEVGTNIH----IKNI 312
            |..||::..|||...||:.||||||:|::          |..:..:|   ..|.::.    :.|.
Human   217 EIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYD---RHGDHLQPLDLVPNH 278

  Fly   313 QNLTPLTLAAKLGRVEMFFHVMSIEREIYWQLGSITCAAYPLLMIDTINEETGNINKDSVLNFVV 377
            |.|||..||...|...||.|:|...:...|..|.:|...|.|..||:..:|      .|:|..::
Human   279 QGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDE------QSLLELII 337

  Fly   378 FGDKLEHLELLDGV-VIDLLKTKWDTFCKSRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDG 441
            ...|.|..::||.. |.:|:..||..:.:..|.....::.||.:......|.||.....:.....
Human   338 TTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSP 402

  Fly   442 ANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMN 506
            .::|..:..|.::                           .|..|.:
Human   403 RDNTLLQQKLLQE---------------------------AYMTPKD------------------ 422

  Fly   507 LESDLAKLRIMAELLNFVGAILYLLVALREARFLGL-KMFIENLMTAPSRVMFL-FSCALMMTIP 569
                  .:|::.||:..:|||:.|||.:.:...:|: :.|.:.::..|..|:.: ::..:::|:.
Human   423 ------DIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTMV 481

  Fly   570 WLRVSCLTEIDDHVTVVIMLTTAPYF-----LFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLV 629
            ...:|...|       |:.::.|...     ::|.|||:.:|||.:||.:|:.|||:||..:..|
Human   482 MRLISASGE-------VVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAV 539

  Fly   630 FVMGFSQAFYIIFLTFDNPSSPEDQDAESNPMPSPMESIVAMFLMSLTNFGDYYGAMVSTQHEYE 694
            .::||:.||||||.|.|    ||:. ......|..:.|...:||..:....:|     :....:.
Human   540 VILGFASAFYIIFQTED----PEEL-GHFYDYPMALFSTFELFLTIIDGPANY-----NVDLPFM 594

  Fly   695 AKILFFLFMVIVSVLLVNMLIAMMGNTYQKIAEIRNE-WQRQWARIVLVVERSVPPAERLKNFMQ 758
            ..|.:..|.:|.::|::|:||||||:|:.::|..|:| |:.|.....:::||.:|..       .
Human   595 YSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRC-------L 652

  Fly   759 YSQSMSDGRR-ALVLRLNMTEEEKEEMKEVQEMKRIHQRF 797
            :.:|...||. .|..|..:..|:::::.. |.::|..|.|
Human   653 WPRSGICGREYGLGDRWFLRVEDRQDLNR-QRIQRYAQAF 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	29/76 (38%)
		ANK	<131..200	CDD:238125	25/67 (37%)
		ANK repeat	138..174	CDD:293786	12/35 (34%)
		ANK	178..329	CDD:238125	58/164 (35%)
		ANK repeat	179..229	CDD:293786	18/49 (37%)
		Ank_2	184..311	CDD:289560	48/140 (34%)
		ANK repeat	231..278	CDD:293786	18/46 (39%)
		ANK repeat	280..311	CDD:293786	10/44 (23%)
		Ion_trans	519..727	CDD:278921	62/214 (29%)
TRPV6	NP_061116.5	trp	52..698	CDD:273311	187/690 (27%)
		ANK 1	84..114		0/1 (0%)
		ANK repeat	86..116	CDD:293786	0/3 (0%)
		ANK repeat	118..150	CDD:293786	12/34 (35%)
		ANK 2	118..147		12/31 (39%)
		ANK	119..242	CDD:238125	58/147 (39%)
		Interaction with calmodulin. /evidence=ECO:0000250	133..143		3/11 (27%)
		ANK repeat	156..187	CDD:293786	12/30 (40%)
		ANK 3	156..185		12/28 (43%)
		ANK	201..>303	CDD:238125	41/104 (39%)
		ANK repeat	202..233	CDD:293786	16/30 (53%)
		ANK 4	202..231		16/28 (57%)
		ANK 5	235..277		10/44 (23%)
		ANK 5	279..308		11/28 (39%)
		Selectivity filter. /evidence=ECO:0000305\|PubMed:29258289	581..585		0/3 (0%)
		Interaction with S100A10. /evidence=ECO:0000250	638..642		0/3 (0%)
		Interaction with calmodulin. /evidence=ECO:0000269\|PubMed:11248124, ECO:0000269\|PubMed:15184369	731..751
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145085
Domainoid	1	1.000	98	1.000	Domainoid score	I7198
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3588
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	1	1.000	-	-		mtm8438
orthoMCL	1	0.900	-	-		OOG6_105955
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4284
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790