DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nan and TRPV2

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_057197.2	Gene:	TRPV2 / 51393	HGNCID:	18082	Length:	764	Species:	Homo sapiens

Alignment Length:	811	Identity:	200/811 - (24%)
Similarity:	324/811 - (39%)	Gaps:	228/811 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 STQALYKFVNLKGG---GLLVDMMK------RACQTKQFAEIDHAIKTKVEPFL-YNKGAGRYFP 73
            |:..:::...|.||   |...|..|      ......||...|.....::...| |.||.|...|
Human     5 SSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNYRKGTGASQP 69

  Fly    74 ISKLVLLRNR-DRPR-----TRQLPEIRALENPDDDFNIHDYCPEVS----EAEYISNPTAYRFV 128
            ..      || ||.|     :|.:||        |...:.:|..:.|    ::||....|..  .
Human    70 DP------NRFDRDRLFNAVSRGVPE--------DLAGLPEYLSKTSKYLTDSEYTEGSTGK--T 118

  Fly   129 CW---DLNMRGAVGETILHLCLLNASSLHADLAKRLLKFYPKLILDIYMSDEYY-GESVLHIAIV 189
            |.   .||::..|...||.|..::..|.:           |:.:::...:|:|| |.|.|||||.
Human   119 CLMKAVLNLKDGVNACILPLLQIDRDSGN-----------PQPLVNAQCTDDYYRGHSALHIAIE 172

  Fly   190 NEDPAMVKYLLDANADVQERCCGA-FMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLS 253
            ......||.|::..|:|..|.||. |...:.|.|                       |:||.|||
Human   173 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCF-----------------------YFGELPLS 214

  Fly   254 FAACLSQEECFRLVLARGADP---DFQDTNGNTVLHMLVIY-----EKI----EMFDVGYEVGTN 306
            .|||..|.:....:|.....|   ...|:.||||||.||:.     |.|    .|:|...:.|..
Human   215 LAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGAR 279

  Fly   307 I-------HIKNIQNLTPLTLAAKLGRVEMFFHVMSIEREI-----------YWQLGSITCAAYP 353
            :       .|:|:|:||||.||||.|::|:|.|:  ::||.           .|..|.:..:.|.
Human   280 LCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHI--LQREFSGLSHLSRKFTEWCYGPVRVSLYD 342

  Fly   354 LLMIDTINEETGNINKDSVLNFVVFGDKLEHLELLDGVVID----LLKTKWDTFCKSRFYKQFYM 414
            |..:|:..|       :|||..:.|..|..|...:  ||::    ||:.|||.     ...:|::
Human   343 LASVDSCEE-------NSVLEIIAFHCKSPHRHRM--VVLEPLNKLLQAKWDL-----LIPKFFL 393

  Fly   415 FALYFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLN 479
            ..|..||.:|.|                   ||
Human   394 NFLCNLIYMFIF-------------------TA-------------------------------- 407

  Fly   480 FTEYYDPS-EVEVLPAWWESYAQCPLMNLESDLA-KLRIMAELLNFVGAILYLLVA-----LREA 537
             ..|:.|: :.:..|            :|::::. .:.:...:|..:|.| ||||.     .|..
Human   408 -VAYHQPTLKKQAAP------------HLKAEVGNSMLLTGHILILLGGI-YLLVGQLWYFWRRH 458

  Fly   538 RFLGLKMFIENLMTAPSRVMFLFSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPY--FLFFCR 600
            .|:.:. ||::..    .::|||. ||:..:.  :|.|...|:.::.:::......:  .|::.|
Human   459 VFIWIS-FIDSYF----EILFLFQ-ALLTVVS--QVLCFLAIEWYLPLLVSALVLGWLNLLYYTR 515

  Fly   601 GFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQDAESNPMPSP- 664
            ||:..|.:.|||.::::.|||||:.|||||:.||:.|...:......|.:|...:|..:..|..
Human   516 GFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEG 580

  Fly   665 -------------MESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILFFL--FMVIVSVLLVNML 714
                         :|:.:.:|..:: ..|:   .....|..:...:|..|  ::::..:||:|||
Human   581 QEDEGNGAQYRGILEASLELFKFTI-GMGE---LAFQEQLHFRGMVLLLLLAYVLLTYILLLNML 641

  Fly   715 IAMMGNTYQKIA-EIRNEWQRQWARIVLVVE 744
            ||:|..|...:| :..:.|:.|.|..||.:|
Human   642 IALMSETVNSVATDSWSIWKLQKAISVLEME 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	23/78 (29%)
		ANK	<131..200	CDD:238125	20/69 (29%)
		ANK repeat	138..174	CDD:293786	6/35 (17%)
		ANK	178..329	CDD:238125	58/171 (34%)
		ANK repeat	179..229	CDD:293786	19/51 (37%)
		Ank_2	184..311	CDD:289560	43/146 (29%)
		ANK repeat	231..278	CDD:293786	12/49 (24%)
		ANK repeat	280..311	CDD:293786	14/46 (30%)
		Ion_trans	519..727	CDD:278921	60/231 (26%)
TRPV2	NP_057197.2	Required for interaction with SLC50A1. /evidence=ECO:0000250	1..388		122/448 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		9/40 (23%)
		trp	27..764	CDD:273311	194/789 (25%)
		ANK repeat	116..159	CDD:293786	9/55 (16%)
		ANK repeat	162..193	CDD:293786	12/30 (40%)
		ANK	163..314	CDD:238125	59/175 (34%)
		ANK repeat	208..242	CDD:293786	11/33 (33%)
		ANK repeat	244..278	CDD:293786	12/33 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	562..585		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..756
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145086
Domainoid	1	1.000	75	1.000	Domainoid score	I9056
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48943
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.820