DRSC/TRiP Functional Genomics Resources

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Protein Alignment nan and TRPV2

DIOPT Version :10

Sequence 1:NP_001261833.1 Gene:nan / 39571 FlyBaseID:FBgn0036414 Length:834 Species:Drosophila melanogaster
Sequence 2:NP_057197.2 Gene:TRPV2 / 51393 HGNCID:18082 Length:764 Species:Homo sapiens


Alignment Length:811 Identity:200/811 - (24%)
Similarity:324/811 - (39%) Gaps:228/811 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 STQALYKFVNLKGG---GLLVDMMK------RACQTKQFAEIDHAIKTKVEPFL-YNKGAGRYFP 73
            |:..:::...|.||   |...|..|      ......||...|.....::...| |.||.|...|
Human     5 SSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNYRKGTGASQP 69

  Fly    74 ISKLVLLRNR-DRPR-----TRQLPEIRALENPDDDFNIHDYCPEVS----EAEYISNPTAYRFV 128
            ..      || ||.|     :|.:||        |...:.:|..:.|    ::||....|..  .
Human    70 DP------NRFDRDRLFNAVSRGVPE--------DLAGLPEYLSKTSKYLTDSEYTEGSTGK--T 118

  Fly   129 CW---DLNMRGAVGETILHLCLLNASSLHADLAKRLLKFYPKLILDIYMSDEYY-GESVLHIAIV 189
            |.   .||::..|...||.|..::..|.:           |:.:::...:|:|| |.|.|||||.
Human   119 CLMKAVLNLKDGVNACILPLLQIDRDSGN-----------PQPLVNAQCTDDYYRGHSALHIAIE 172

  Fly   190 NEDPAMVKYLLDANADVQERCCGA-FMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLS 253
            ......||.|::..|:|..|.||. |...:.|.|                       |:||.|||
Human   173 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCF-----------------------YFGELPLS 214

  Fly   254 FAACLSQEECFRLVLARGADP---DFQDTNGNTVLHMLVIY-----EKI----EMFDVGYEVGTN 306
            .|||..|.:....:|.....|   ...|:.||||||.||:.     |.|    .|:|...:.|..
Human   215 LAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGAR 279

  Fly   307 I-------HIKNIQNLTPLTLAAKLGRVEMFFHVMSIEREI-----------YWQLGSITCAAYP 353
            :       .|:|:|:||||.||||.|::|:|.|:  ::||.           .|..|.:..:.|.
Human   280 LCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHI--LQREFSGLSHLSRKFTEWCYGPVRVSLYD 342

  Fly   354 LLMIDTINEETGNINKDSVLNFVVFGDKLEHLELLDGVVID----LLKTKWDTFCKSRFYKQFYM 414
            |..:|:..|       :|||..:.|..|..|...:  ||::    ||:.|||.     ...:|::
Human   343 LASVDSCEE-------NSVLEIIAFHCKSPHRHRM--VVLEPLNKLLQAKWDL-----LIPKFFL 393

  Fly   415 FALYFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLN 479
            ..|..||.:|.|                   ||                                
Human   394 NFLCNLIYMFIF-------------------TA-------------------------------- 407

  Fly   480 FTEYYDPS-EVEVLPAWWESYAQCPLMNLESDLA-KLRIMAELLNFVGAILYLLVA-----LREA 537
             ..|:.|: :.:..|            :|::::. .:.:...:|..:|.| ||||.     .|..
Human   408 -VAYHQPTLKKQAAP------------HLKAEVGNSMLLTGHILILLGGI-YLLVGQLWYFWRRH 458

  Fly   538 RFLGLKMFIENLMTAPSRVMFLFSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPY--FLFFCR 600
            .|:.:. ||::..    .::|||. ||:..:.  :|.|...|:.::.:::......:  .|::.|
Human   459 VFIWIS-FIDSYF----EILFLFQ-ALLTVVS--QVLCFLAIEWYLPLLVSALVLGWLNLLYYTR 515

  Fly   601 GFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQDAESNPMPSP- 664
            ||:..|.:.|||.::::.|||||:.|||||:.||:.|...:......|.:|...:|..:..|.. 
Human   516 GFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEG 580

  Fly   665 -------------MESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILFFL--FMVIVSVLLVNML 714
                         :|:.:.:|..:: ..|:   .....|..:...:|..|  ::::..:||:|||
Human   581 QEDEGNGAQYRGILEASLELFKFTI-GMGE---LAFQEQLHFRGMVLLLLLAYVLLTYILLLNML 641

  Fly   715 IAMMGNTYQKIA-EIRNEWQRQWARIVLVVE 744
            ||:|..|...:| :..:.|:.|.|..||.:|
Human   642 IALMSETVNSVATDSWSIWKLQKAISVLEME 672

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nanNP_001261833.1 TRPV 131..748 CDD:454755 169/676 (25%)
ANK repeat 138..174 CDD:293786 6/35 (17%)
ANK repeat 179..229 CDD:293786 19/51 (37%)
ANK repeat 231..278 CDD:293786 12/49 (24%)
ANK repeat 280..311 CDD:293786 14/46 (30%)
TRPV2NP_057197.2 Required for interaction with SLC50A1. /evidence=ECO:0000250|UniProtKB:Q9WUD2 1..388 122/448 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46 9/40 (23%)
TRPV2 70..709 CDD:411981 184/746 (25%)
ANK repeat 116..159 CDD:293786 9/55 (16%)
ANK repeat 162..193 CDD:293786 12/30 (40%)
ANK repeat 208..242 CDD:293786 11/33 (33%)
ANK repeat 244..278 CDD:293786 12/33 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 562..585 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 725..756
Blue background indicates that the domain is not in the aligned region.

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