DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nan and Trpv3

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_017452952.1	Gene:	Trpv3 / 497948	RGDID:	1564531	Length:	793	Species:	Rattus norvegicus

Alignment Length:	737	Identity:	177/737 - (24%)
Similarity:	306/737 - (41%)	Gaps:	199/737 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 GETILHLCLLNASSLHADLAKRLLKFYPKL-ILDIYMSDE-----YYGESVLHIAIVNEDPAMVK 197
            |:|.|...|||.:....::.:.||.|..:. |||.:::.|     |.|::.|:|||......:..
  Rat   170 GKTCLMKALLNINPNTKEIVRILLAFAEENDILDRFINAEYTEEAYEGQTALNIAIERRQGDITA 234

  Fly   198 YLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACLSQEE 262
            .|:.|.|||.....|.|.:                    |...::|: |:||.||:.|||.:|.|
  Rat   235 VLIAAGADVNAHAKGVFFN--------------------PKYQHEGF-YFGETPLALAACTNQPE 278

  Fly   263 CFRLVLA-RGADPDFQDTNGNTVLHMLV---------------IYEKIEMFDVGYEVGTNIHIKN 311
            ..:|::. ...|...||:.||.:||.||               :|:.|.:....:|:.|   ::|
  Rat   279 IVQLLMENEQTDITSQDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELET---MRN 340

  Fly   312 IQNLTPLTLAAKLGRVEMFFHVM----------SIEREIY-WQLGSITCAAYPLLMIDTINEETG 365
            ...||||.||||:|:.|:..:::          |:.|:.. |..|.::.:.|.|..:||..:
  Rat   341 NDGLTPLQLAAKMGKAEILKYILGREIKEKPLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTD--- 402

  Fly   366 NINKDSVLNFVVFGDKLEH------LELLDGVVIDLLKTKWDTFCKSRFYKQFYMFALYFLISLF 424
                :|||..:|:...:::      ||.|.    .||..||..|.|   |..|..|..||..::
  Rat   403 ----NSVLEIIVYNTNIDNRHEMLTLEPLH----TLLHMKWKKFAK---YMFFLSFCFYFFYNI- 455

  Fly   425 SFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLNFTEYYDPSEV 489
                                                       |:|         ...||.|.|.
  Rat   456 -------------------------------------------TLT---------LVSYYRPRED 468

  Fly   490 EVLPAWWESYAQCPLMNLESDLAKLRIMAELLNFV---------GAILYLL------VALREARF 539
            |.||.        ||. |...::.|:::..:...:         |..::||      ..|.:|.|
  Rat   469 EALPH--------PLA-LTHKMSWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWF 524

  Fly   540 LGLKMFIENLMTAPSRVMFLF------SC-ALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYFLF 597
             ....|::.::...|..::||      :| .|.|.:.|..:                      |:
  Rat   525 -HFVFFVQAVLVILSVFLYLFAYKEYLACLVLAMALGWANM----------------------LY 566

  Fly   598 FCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQDAESNPMP 662
            :.|||:::|.:.|||.::::.|:|:|:.:|::|::||..|...:.    ...|.:.:|..|  ..
  Rat   567 YTRGFQSMGMYSVMIQKVILHDVLKFLFVYILFLLGFGVALASLI----EKCSKDKKDCSS--YG 625

  Fly   663 SPMESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILFFL--FMVIVSVLLVNMLIAMMGNTYQKI 725
            |..::::.:|.::: ..||......||   |....||.|  ::::..|||:|||||:||.|.:.:
  Rat   626 SFSDAVLELFKLTI-GLGDLNIQQNST---YPILFLFLLITYVILTFVLLLNMLIALMGETVENV 686

  Fly   726 A-EIRNEWQRQWARIVLVVERSVPPAERLKNFMQYSQSMSDGRRALVLRLNMTE--EEKEEMKEV 787
            : |....|:.|.||.:|..|:.:|...|.:..|.....::|....|.||:|..:  |.|..:..:
  Rat   687 SKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVADEDFRLCLRINEVKWTEWKTHVSFL 751

  Fly   788 QEMKRIHQRFAKKRQMEREARA 809
            .|.....:|.|...:::..:|:
  Rat   752 NEDPGPIRRTADSNKIQDSSRS 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	24/75 (32%)
		ANK	<131..200	CDD:238125	19/66 (29%)
		ANK repeat	138..174	CDD:293786	12/35 (34%)
		ANK	178..329	CDD:238125	49/166 (30%)
		ANK repeat	179..229	CDD:293786	12/49 (24%)
		Ank_2	184..311	CDD:289560	37/142 (26%)
		ANK repeat	231..278	CDD:293786	14/47 (30%)
		ANK repeat	280..311	CDD:293786	10/45 (22%)
		Ion_trans	519..727	CDD:278921	54/232 (23%)
Trpv3	XP_017452952.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338793
Domainoid	1	1.000	75	1.000	Domainoid score	I8820
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8914
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.810