DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nan and Trpv5

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001007573.1	Gene:	Trpv5 / 194352	MGIID:	2429764	Length:	723	Species:	Mus musculus

Alignment Length:	716	Identity:	194/716 - (27%)
Similarity:	320/716 - (44%)	Gaps:	143/716 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 DLNMRGAVGETILHLCLLNASSLHADLAKRLLKFYPKLILDIYMSDEYYGESVLHIAIVNEDPAM 195
            |...|||:|||.||:..|..   :.|.|..|::..|.|:.:..:.:.:.|::.||||::|::..:
Mouse    65 DFRQRGALGETALHVAALYD---NLDAAIMLMEAAPYLVTESTLCEPFVGQTALHIAVMNQNVNL 126

  Fly   196 VKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACLSQ 260
            |:.||...|....|..|       :.|.|:.               ...:|:||:|||||||:..
Mouse   127 VRALLARGASASARATG-------SAFHRSS---------------HNLIYYGEHPLSFAACVGS 169

  Fly   261 EECFRLVLARGADPDFQDTNGNTVLHMLVI----------YEKIEMFDVGYEVGTNIHIKNIQNL 315
            ||..||::..|||...||:.||||||:||:          |..:..:|.|..:.:...:.|.|.|
Mouse   170 EEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGL 234

  Fly   316 TPLTLAAKLGRVEMFFHVMSIEREIYWQLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVFGD 380
            ||..||...|...||.|:|...:.|.|..|.:|.:.|.|..||:..||.      |.|..||...
Mouse   235 TPFKLAGVEGNTVMFQHLMQKRKRIQWSFGPLTSSLYDLTEIDSWGEEL------SFLELVVSSK 293

  Fly   381 KLEHLELLDGV-VIDLLKTKWDTFCKSRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDGANS 444
            |.|..::|:.. |.:|:..||..:.:..|.....::..|.:......:.||   .|..|   ||.
Mouse   294 KKEARQILEQTPVKELVSLKWKKYGQPYFCLLGALYIFYMVCFTTCCVYRP---LKFRD---ANR 352

  Fly   445 TTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNLES 509
            |               |:   |.....|.|:....:..|.|
Mouse   353 T---------------HV---RDNTIMEQKSLQEAYVTYQD------------------------ 375

  Fly   510 DLAKLRIMAELLNFVGAILYLLVALREARFLGL-KMFIENLMTAPSRVMFLFSCALMMTIPWLRV 573
               |:|::.||:..:||::.||:.:.:...:|. :.|.:.::..|..|:.:...:|::....:|
Mouse   376 ---KIRLVGELVTVIGAVIILLLEIPDIFRVGASRYFGQTVLGGPFHVIIITYASLVLLTMAMR- 436

  Fly   574 SCLTEIDDHVTVVIMLTTAPY--FLFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQ 636
              ||.::..|..:.|.....:  .::|.|||:.:|||.:||.:|:.||||||..:..:.::||:.
Mouse   437 --LTNVNGEVVPMSMALVLGWCSVMYFARGFQMLGPFTIMIQKMIFGDLLRFCWLMAMVILGFAS 499

  Fly   637 AFYIIFLTFDNPSSPEDQD--AESNPMPSPMESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILF 699
            ||||||.|       ||.|  .|.:..|:.|.|...:||..:....:|   .|.....|  .:.:
Mouse   500 AFYIIFQT-------EDPDNLGEFSDYPTAMFSTFELFLTIIDGPANY---RVDLPFMY--SVTY 552

  Fly   700 FLFMVIVSVLLVNMLIAMMGNTYQKIAEIRNE-WQRQWARIVLVVERSVPP-------------- 749
            ..|.:|.::|::|:.|||||:|:.::|:.|:| |:.|.....:::||.:|.
Mouse   553 ATFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGCEYG 617

  Fly   750 -AERLKNFMQYSQSMSDGRRALVLRL--NMTEEEKEEMKEVQEMKRIHQRFAKKRQMEREARALR 811
             .:|....:::.|..:..|   |||.  .....:|||::|         :.::|:....|...|.
Mouse   618 LGDRWFLRVEHHQEQNPYR---VLRYVEAFKSSDKEEVQE---------QLSEKQPSGTETGTLA 670

  Fly   812 R 812
            |
Mouse   671 R 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	25/77 (32%)
		ANK	<131..200	CDD:238125	22/68 (32%)
		ANK repeat	138..174	CDD:293786	11/35 (31%)
		ANK	178..329	CDD:238125	52/160 (33%)
		ANK repeat	179..229	CDD:293786	14/49 (29%)
		Ank_2	184..311	CDD:289560	43/136 (32%)
		ANK repeat	231..278	CDD:293786	17/46 (37%)
		ANK repeat	280..311	CDD:293786	11/40 (28%)
		Ion_trans	519..727	CDD:278921	63/212 (30%)
Trpv5	NP_001007573.1	trp	5..701	CDD:273311	194/716 (27%)
		ANK 1. /evidence=ECO:0000255	38..68		1/2 (50%)
		ANK 2. /evidence=ECO:0000255	72..101		11/31 (35%)
		ANK repeat	73..101	CDD:293786	11/30 (37%)
		ANK 3. /evidence=ECO:0000255	110..139		10/28 (36%)
		ANK repeat	111..154	CDD:293786	14/64 (22%)
		ANK repeat	156..187	CDD:293786	16/30 (53%)
		ANK 4. /evidence=ECO:0000255	156..185		16/28 (57%)
		ANK 5. /evidence=ECO:0000255	189..222		11/32 (34%)
		ANK repeat	189..219	CDD:293786	10/29 (34%)
		ANK 6. /evidence=ECO:0000255	232..261		12/28 (43%)
		Interaction with S100A10. /evidence=ECO:0000269\|PubMed:12660155	591..595		0/3 (0%)
		Involved in Ca(2+)-dependent inactivation. /evidence=ECO:0000250	643..646		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..673		6/30 (20%)
		Involved in Ca(2+)-dependent inactivation. /evidence=ECO:0000250	693..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835191
Domainoid	1	1.000	104	1.000	Domainoid score	I6693
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	223	1.000	Inparanoid score	I3510
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	1	1.000	-	-		mtm8679
orthoMCL	1	0.900	-	-		OOG6_105955
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4284
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.790