DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nan and ocr-2

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_501380.1	Gene:	ocr-2 / 188314	WormBaseID:	WBGene00003839	Length:	900	Species:	Caenorhabditis elegans

Alignment Length:	927	Identity:	311/927 - (33%)
Similarity:	485/927 - (52%)	Gaps:	164/927 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNTESNVTSGVKKQAGV----STQALYKFVNLKGGGLLVDMMKRACQTKQFAEIDHAIKTKVEP 61
            ||:: |:..|.:....|:    ....:|:.|::.|||.|:..::.|..:...:.||..::|||:.
Worm     1 MGSS-SSTQSSMNNFVGMGRLREDMKIYQLVDMHGGGELLPWLRYAIISSDTSFIDAYLETKVKD 64

  Fly    62 FLYNKGAGRYFPISKLVLLRNRDRPR-----TRQLPEIRALENPDDDFNIHDYCPEVSEAEYIS- 120
            ||||.|.|:...:::||.|||::|..     :|:..:.::..|..||||        .|.|.:.
Worm    65 FLYNGGKGKLVTVTELVKLRNKERNERLGAFSRKKGKGKSGPNVLDDFN--------QEGENVGD 121

  Fly   121 ----------------NPTAYRFVCWDLNMRGAVGETILHLCLLNASSLHADLAKRLLKFYPKLI 169
                            |.:.||.:.|.|..||::||||:..|||:||.:|..|..::|.:||||:
Worm   122 LKKALKLLDGGGKGGRNESKYREISWKLEERGSMGETIIGCCLLHASDIHNALVLKILDYYPKLL 186

  Fly   170 LDIYMSDEYYGESVLHIAIVNEDPAMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVA 234
            .||::|:::||.|.||.||:|.|..:|...|...|||..||.|||..|:|.|.|||||.:||||.
Worm   187 NDIHISEDFYGLSPLHQAIINTDCKLVYKFLKLGADVNSRCYGAFFCADDQKASRTDSLEHEYVE 251

  Fly   235 LCPMTNYDGYVYWGEYPLSFAACLSQEECFRLVLARGADPDFQDTNGNTVLHMLVIYEKIEMFDV 299
            |...|||.|.:|.|||||||||||:|.|.|||:||..|:|:.||||||:||||.||:|.:.||.:
Worm   252 LSLKTNYTGNMYLGEYPLSFAACLNQPESFRLLLAFKANPNAQDTNGNSVLHMCVIHENMAMFKL 316

  Fly   300 GYEVGTNIHIKNIQNLTPLTLAAKLGRVEMFFHVMSIEREIYWQLGSITCAAYPLLMIDTINEET 364
            ..|.|.::...|.|:|:||||||||.:.|||..::.:|.:..|..|..:..||||..||||||.|
Worm   317 ALECGASLRTVNKQSLSPLTLAAKLAKKEMFDEILELEGDSVWAYGDASSTAYPLAKIDTINETT 381

  Fly   365 GNINKDSVLNFVVFGDKLEHLELLDGVVIDLLKTKWDTFCKSRFYKQFYMFALYFLISLFSFILR 429
            |.:|:.|.|:.||:|..:||||||||::..||:.||:.|.|......|..|.||::..:.:|.||
Worm   382 GELNEASALSLVVYGQTVEHLELLDGLLDTLLEAKWEAFAKRNMIVSFTAFTLYYICFVTAFTLR 446

  Fly   430 PGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKT-FWLNFTEYYDP------- 486
            |                                    ...:||..| .|:|  .|.:|
Worm   447 P------------------------------------IGFSTEMLTEGWIN--RYSEPFPGRYGK 473

  Fly   487 --SEVEVLPA----------WWESYAQCPLMNL-ESDL----AKLRIMAELLNFVGAILYLLVAL 534
              :..:|.|.          |.|..:||.|.|. :.|:    :.:|::.||...:|..:.:.:..
Worm   474 NSTLQQVKPVINATSRGLVEWSEPLSQCHLRNYWDPDIPFANSYIRLVFELFVVIGICVQVFLDF 538

  Fly   535 REARFLGLKMFIENLMTAPSRVMFLFSCALMMTIPWLRVSC-----LTEIDDHVTVVIMLTTAPY 594
            |:.:.:|.|.:...|...|:::.|..:..|::.:...|::|     |..:|:.:..|.|:.|..:
Worm   539 RDIKRIGRKKWWNVLTAFPAKITFKLTYFLVLAMIPTRLACDLSPVLLVVDNVLITVTMIFTTVH 603

  Fly   595 FLFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLT------------FDN 647
            :|::||..:.|||||:|:|.::..|:.||:.||.:|:|||||:|.:|||:            .|.
Worm   604 YLYYCRVIRFVGPFVLMVYTIIATDIFRFMLIYGIFLMGFSQSFSLIFLSCEREANVIKKLITDQ 668

  Fly   648 PSSPEDQD-------------------AE--SNPMPSPMESIVAMFLMSLTNFGDYY-------- 683
            ..:.|..|                   ||  .|.|.||:|:.|..|::::..|...|
Worm   669 SEASEGSDNKFNLTRQISAYDTAIVKNAEVFENVMQSPIEAFVRTFILTIGEFTVLYRNLALCPA 733

  Fly   684 GAMVSTQHEYEAKILFFLFMVIVSVLLVNMLIAMMGNTYQKIAEIRNEWQRQWARIVLVVERSVP 748
            ..||     :..|::|.||.:.||::..|||||||..||:.|.:.:.|::||.|:::|::|.|:.
Worm   734 NTMV-----WIGKVVFILFELFVSIMQFNMLIAMMTRTYETIFQTQLEYKRQRAQVILMLELSLS 793

  Fly   749 PAERLKNFMQYSQSMSDGR--RALVL--RLNMTEEEKEEMKEVQEMKRIHQRFAKKRQMEREARA 809
            |.||.:..::||:.....:  |:||:  :...:.:.|:..|.::|         |.::|..|.:|
Worm   794 PKERHQYLLKYSRPTGTNKKTRSLVVSKKSAFSRDSKKGQKVLEE---------KMKKMIEEKKA 849

  Fly   810 L--RRQQEYEKFFGTAP 824
            :  |:.::.|...|..|
Worm   850 VLKRKMKDMEIKEGIRP 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	36/77 (47%)
		ANK	<131..200	CDD:238125	32/68 (47%)
		ANK repeat	138..174	CDD:293786	18/35 (51%)
		ANK	178..329	CDD:238125	85/150 (57%)
		ANK repeat	179..229	CDD:293786	27/49 (55%)
		Ank_2	184..311	CDD:289560	71/126 (56%)
		ANK repeat	231..278	CDD:293786	29/46 (63%)
		ANK repeat	280..311	CDD:293786	14/30 (47%)
		Ion_trans	519..727	CDD:278921	74/253 (29%)
ocr-2	NP_501380.1	trp	137..789	CDD:273311	253/694 (36%)
		ANK repeat	196..262	CDD:293786	36/65 (55%)
		ANK repeat	264..295	CDD:293786	20/30 (67%)
		ANK repeat	297..328	CDD:293786	14/30 (47%)
		ANK repeat	330..355	CDD:293786	13/24 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48943
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105955
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.790