DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nan and ocr-4

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_501172.2	Gene:	ocr-4 / 177506	WormBaseID:	WBGene00003841	Length:	756	Species:	Caenorhabditis elegans

Alignment Length:	843	Identity:	324/843 - (38%)
Similarity:	464/843 - (55%)	Gaps:	113/843 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGNTESNVTSGVKKQAGVSTQALYKFVNLKGGGLLVDMMKRACQTKQFAEIDHAIKTKVEPFLYN 65
            |||..|.||:|:|.|...|..|:.|..::.|.|.|.|:...|.:|....|:|..|..||:|.|||
Worm     1 MGNASSAVTAGIKNQVNASNNAINKLADMSGRGFLADLAMDAVRTGNHEELDKQILEKVQPMLYN 65

  Fly    66 KGAGRYFPISKLVLLRNRDRP-RTRQLPEIRALENPDDDFNIHDYCPEVSEAEYISNPTAYRFVC 129
            .|.|...|:|.|:..|:::|. .|..:|                 .|.          |..||:|
Worm    66 NGQGEMIPLSDLIAQRHKERTGNTFAVP-----------------VPS----------TECRFIC 103

  Fly   130 WDLNMRGAVGETILHLCLLNASSLHAD-LAKRLLKFYPKLILDIYMSDEYYGESVLHIAIVNEDP 193
            |.||.|||||||:||.|.|.....|.. ||:||:..:||:|.|.|:|||||||:|||:.||:|:.
Worm   104 WKLNSRGAVGETLLHTCFLAGLPNHMKLLAERLIAIFPKIINDFYLSDEYYGETVLHMGIVSENA 168

  Fly   194 AMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACL 258
            ..|:|||.:.|||..||.|.|.:.:|.|.||||.|:.|:..:...|.|.|::|||||||||||||
Worm   169 EFVRYLLKSGADVHARCSGNFFTCDDQKGSRTDHPEVEHAIISKHTKYPGHIYWGEYPLSFAACL 233

  Fly   259 SQEECFRLVLARGADPDFQDTNGNTVLHMLVIYEKIEMFDVGYEVGTNIHIKNIQNLTPLTLAAK 323
            ||.||.|:::|.|||.:..||||||:||:..|:|..|||.:...:|.::||:|.||||||||||.
Worm   234 SQPECIRMLVAHGADVNAADTNGNTILHICTIHENYEMFKMALSLGADLHIQNRQNLTPLTLAAF 298

  Fly   324 LGRVEMFFHVMSIEREIYWQLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVFGDKLEHLELL 388
            |.:.||...::..||.:.|..|....|||||..:|:|...:|:||:.|||...|:|:|:|||.||
Worm   299 LAKKEMMQRIVEEERTVNWTYGRTQSAAYPLEHVDSIEPTSGSINQKSVLTIAVYGEKVEHLSLL 363

  Fly   389 DGVVIDLLKTKWDTFCKSRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYR 453
            ..::..|:..||..:.:...:.|..||.:||:.....|:|||.|  .:..:..||......|...
Worm   364 PHLLEQLVHHKWIAYGRKTLFAQLSMFCIYFICVTSCFLLRPSP--FERQQHIANDLICFYDFKT 426

  Fly   454 QNGSDS------YHLHSKRATMTTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNLESDLA 512
            :..::|      |||
Worm   427 RRFNESAVSTIIYHL-------------------------------------------------- 441

  Fly   513 KLRIMAELLNFVGAILYLLVALREARFLGLKMFIENLMTAPSRVMFLFSCALMMTIPWLRVSCLT 577
                 ..|:...||.|||:.||...:.:|..:::..|...|::.:|||||.||:...:||:.||.
Worm   442 -----LHLICVTGATLYLVQALLHIKNVGYHLYVLGLSGFPAKAIFLFSCILMVITFFLRIFCLD 501

  Fly   578 EIDDHVTVVIMLTTAPYFLFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIF 642
            |.:|.|.:||:|.|:..|||||||||:|||||:|:|::::.||:||..||||.|:|||||||:||
Worm   502 EAEDIVWIVIVLLTSLKFLFFCRGFKSVGPFVLMLYKIIIRDLMRFFLIYLVIVVGFSQAFYVIF 566

  Fly   643 LTFDNPSSPEDQDAESNPMPSPMESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILFFLFMVIVS 707
            |.:....|   .:.|.:.|.:..||.|.||:||||.|..::..:...:|....||.|.::|::|:
Worm   567 LGYKRSDS---GNREPSIMSNVAESYVRMFIMSLTEFTVFFEQLEECEHTVIGKITFVVYMLLVT 628

  Fly   708 VLLVNMLIAMMGNTYQKIAEIRNEWQRQWARIVLVVERSVPPAERLKNFMQYSQSMSDGRR-ALV 771
            :||:|||||||.|||.:::....||.|||:.|:|::|:|..||.||:...:|......|.: .|:
Worm   629 LLLINMLIAMMTNTYTEVSGNSLEWLRQWSAIILMMEQSFDPATRLRYQRRYGIRFDGGEKLVLL 693

  Fly   772 LRLNMTEEEKEEMKEVQEMKRIHQRFAKKRQMEREARALRRQQEYEKFFGTAPKSECSDNNNF 834
            |:..|||||.|     .:.|::|:   ::|:...|.|..:|::         |...|....|:
Worm   694 LKDKMTEEEFE-----CQRKKMHE---ERRKFREELRTNQRRR---------PVFICKQGANY 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	43/78 (55%)
		ANK	<131..200	CDD:238125	38/69 (55%)
		ANK repeat	138..174	CDD:293786	17/36 (47%)
		ANK	178..329	CDD:238125	82/150 (55%)
		ANK repeat	179..229	CDD:293786	26/49 (53%)
		Ank_2	184..311	CDD:289560	65/126 (52%)
		ANK repeat	231..278	CDD:293786	26/46 (57%)
		ANK repeat	280..311	CDD:293786	14/30 (47%)
		Ion_trans	519..727	CDD:278921	95/207 (46%)
ocr-4	NP_501172.2	trp	105..668	CDD:273311	258/622 (41%)
		ANK repeat	154..194	CDD:293786	20/39 (51%)
		ANK repeat	196..253	CDD:293786	32/56 (57%)
		ANK repeat	255..286	CDD:293786	14/30 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167763
Domainoid	1	1.000	184	1.000	Domainoid score	I2029
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H71056
Inparanoid	1	1.050	554	1.000	Inparanoid score	I608
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48943
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	1	1.000	-	-		oto19036
orthoMCL	1	0.900	-	-		OOG6_105955
Panther	1	1.100	-	-	LDO	PTHR10582
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4284
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800