DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nan and osm-9

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_500372.1	Gene:	osm-9 / 177117	WormBaseID:	WBGene00003889	Length:	937	Species:	Caenorhabditis elegans

Alignment Length:	803	Identity:	232/803 - (28%)
Similarity:	384/803 - (47%)	Gaps:	149/803 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LYKFVNLKGGGLLVDMMKRACQ--TKQFAEIDHAIKTKVEPFLYNKGAGRYFPISKLVLLRNRDR 85
            |||:|.::.||.|:::.:|..:  ..:|||      .|:...||::|..     .|||...:
Worm    39 LYKWVAVRKGGELINIYERDGEEGVLKFAE------EKLLTILYDEGQN-----PKLVTYSD--- 89

  Fly    86 PRTRQLPEIRALENPDDDFNIHDYCPEVSEAEYISNPTAYRFVCWDLNMRGAVGETILHLCLLNA 150
                   .|:..:..:....:.:...::.::.:..:     :..|.||.||..||.::||.|...
Worm    90 -------YIKWKKGVNVQLGLSEESVDMQQSRFKEH-----YALWKLNKRGVEGENLIHLLLNRE 142

  Fly   151 SSLHADLAKRLLKFYPKLILDIYMSDEYYGESVLHIAIVNEDPAMVKYLLDANADVQERCCGAFM 215
            ..:..::|:.|||.:|.:..|||:.||.:|:|.||:|||::|...|..||::.|||..|.||.|.
Worm   143 QQVCYEIARILLKRFPGMANDIYLGDEQFGQSALHLAIVHDDYETVSLLLNSKADVNARACGNFF 207

  Fly   216 SAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACLSQEECFRLVLARGADPDFQDTN 280
            ..||.|.:.            .:|:|.||.|:|||||:||||...::.:.|::..||:|:.||:.
Worm   208 LPEDFKLTN------------KITDYQGYAYYGEYPLAFAACFGNKDIYDLLIQFGANPNLQDSF 260

  Fly   281 GNTVLHMLVIYEKIEMFDVGYEV-----GTNIHIKNIQNLTPLTLAAKLGRVEMFFHVMSIEREI 340
            |||:|||.||.....|:  .|.|     ..:.|:.|....||||||.||||.::|..::.|.:..
Worm   261 GNTILHMCVINYSSSMY--SYAVRHWAKPADPHVVNHAGFTPLTLATKLGRKQIFEEMLEIMKVE 323

  Fly   341 YWQLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVFGDKLEHLELLDGVVID-LLKTKWDTFC 404
            :|:...:||:||||..:|||..: |:.|.||.|..|:.|...|||:::...||. ||..||..|.
Worm   324 FWRFSDMTCSAYPLNTLDTIQPD-GSTNYDSALMTVINGSTPEHLDMIGSEVIQRLLADKWKAFA 387

  Fly   405 KSRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATM 469
            :.:..::..:..:..:.......:||
Worm   388 QRKLIERLVLLIVQLITLSIVVYIRP--------------------------------------- 413

  Fly   470 TTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNLESDLAKLRIMAELLNFVGAILYL-LVA 533
             ||....::.     ||.        |:.|              :|...|||..:..|.:: ...
Worm   414 -TELPRLYME-----DPQ--------WDDY--------------IRTACELLTILNCIFFVGYQQ 450

  Fly   534 LREARFLGLKMFIENLMTAPSRVMF-LFSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYFLF 597
            |.|.|..|::.::.||.|||::.:| :.:..|::.||: |:....||::.:.|..:..:..:.||
Worm   451 LGEIRTQGMRGYLRNLKTAPAKAVFCIANLFLLLCIPF-RLMKKHEIEEALFVFALPGSWIFLLF 514

  Fly   598 FCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQDAES---- 658
            |.|..|..||||.|||.|:.||::||..|..:|::.|||.||.:....|.....||.:..:
Worm   515 FARSAKLTGPFVQMIYSMIAGDMIRFAIISAIFLVSFSQVFYFVGKDMDAKQKLEDTNPHACRIS 579

  Fly   659 -------NPMPSPMESIVAMFLMSLTNFGDY-YGAMVSTQHEYEAKILFFLFMVIVSVLLVNMLI 715
                   |..|   |:.:.:|..|:   |.| |.......::...|.||.|:|.::.::::|:||
Worm   580 GYTIYTYNTFP---ETFITLFRASM---GGYDYEEFSCANYQALTKTLFVLYMFVMPIMMINILI 638

  Fly   716 AMMGNTYQK-IAEIRNEWQRQWARIVLVVERSVPPAERLKNFMQYSQSMSDGRRALVLRLNMTEE 779
            |||||||.. ||:....|::|:|:||:|:||||.......:.::||           :||:....
Worm   639 AMMGNTYTTVIAQAEKAWRQQYAQIVMVLERSVGKERLAASQLEYS-----------IRLDQEGS 692

  Fly   780 EKEEMKEVQEMKRIHQRFAKKRQ 802
            ...|::.:..:|:..:..|::|:
Worm   693 SGMEVRGLMVIKQTKKTRARQRK 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	33/77 (43%)
		ANK	<131..200	CDD:238125	28/68 (41%)
		ANK repeat	138..174	CDD:293786	12/35 (34%)
		ANK	178..329	CDD:238125	64/155 (41%)
		ANK repeat	179..229	CDD:293786	21/49 (43%)
		Ank_2	184..311	CDD:289560	51/131 (39%)
		ANK repeat	231..278	CDD:293786	18/46 (39%)
		ANK repeat	280..311	CDD:293786	12/35 (34%)
		Ion_trans	519..727	CDD:278921	72/222 (32%)
osm-9	NP_500372.1	trp	49..789	CDD:273311	227/793 (29%)
		ANK repeat	171..202	CDD:293786	14/30 (47%)
		ANK repeat	227..258	CDD:293786	13/30 (43%)
		ANK repeat	260..294	CDD:293786	12/35 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820