DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nan and TRPV3

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	NP_001245134.1	Gene:	TRPV3 / 162514	HGNCID:	18084	Length:	791	Species:	Homo sapiens

Alignment Length:	761	Identity:	178/761 - (23%)
Similarity:	306/761 - (40%)	Gaps:	221/761 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 GETILHLCLLNASSLHADLAKRLLKF------YPKLILDIYMSDEYYGESVLHIAIVNEDPAMVK 197
            |:|.|...|||.:....::.:.||.|      ..:.|...|..:.|.|::.|:|||......:..
Human   168 GKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAA 232

  Fly   198 YLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACLSQEE 262
            .|:.|.|||.....|||.:                    |...::|: |:||.||:.|||.:|.|
Human   233 LLIAAGADVNAHAKGAFFN--------------------PKYQHEGF-YFGETPLALAACTNQPE 276

  Fly   263 CFRLVLA-RGADPDFQDTNGNTVLHMLV---------------IYEKIEMFDVGYEVGTNIHIKN 311
            ..:|::. ...|...:|:.||.:||.||               :|:.|.:....:|:.|.   :|
Human   277 IVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETT---RN 338

  Fly   312 IQNLTPLTLAAKLGRVEMFFHVMSIEREIY-------------WQLGSITCAAYPLLMIDTINEE 363
            ...||||.||||:|:.|:..:::|  |||.             |..|.::.:.|.|..:||..:
Human   339 NDGLTPLQLAAKMGKAEILKYILS--REIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTD- 400

  Fly   364 TGNINKDSVLNFVVFGDKLEH------LELLDGVVIDLLKTKWDTFCKSRFYKQFYMFALYFLIS 422
                  :|||...|:...:::      ||.|.    .||..||..|.|..|   |..|..||..:
Human   401 ------NSVLEITVYNTNIDNRHEMLTLEPLH----TLLHMKWKKFAKHMF---FLSFCFYFFYN 452

  Fly   423 LFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLNFTEYYDPS 487
            :                                            |:|         ...||.|.
Human   453 I--------------------------------------------TLT---------LVSYYRPR 464

  Fly   488 EVEVLPAWWESYAQCPLMNLESDLAKLRIMAELLNFV---------GAILYLL------VALREA 537
            |.|.:|.        ||. |...:..|:::..:...:         |..::||      ..|.:|
Human   465 EEEAIPH--------PLA-LTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDA 520

  Fly   538 RFLGLKMFIENLMTAPSRVMFLF------SC-ALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYF 595
            .| ....||:.::...|..::||      :| .|.|.:.|..:
Human   521 WF-HFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANM---------------------- 562

  Fly   596 LFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQDAESNP 660
            |::.|||:::|.:.|||.::::.|:|:|:.:|:||::||..|...:.     ...|:| :.:.:.
Human   563 LYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLI-----EKCPKD-NKDCSS 621

  Fly   661 MPSPMESIVAMFLMSLTNFGDYYGAMVSTQHEYEAKILFFL--FMVIVSVLLVNMLIAMMGNTYQ 723
            ..|..::::.:|.::: ..||   ..:....:|....||.|  ::::..|||:|||||:||.|.:
Human   622 YGSFSDAVLELFKLTI-GLGD---LNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVE 682

  Fly   724 KIA-EIRNEWQRQWARIVLVVERSVPPAERLKNFMQYSQSMSDGRRALVLRLNMTEEEKEEMKEV 787
            .:: |....|:.|.||.:|..|:.:|...|.:..|.....:::....|.||:|       |:|..
Human   683 NVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRIN-------EVKWT 740

  Fly   788 QEMKRIHQRFAKKRQMEREARALRRQQEYEKFFGTAPKSECSDNNN 833
            :  .:.|..|     :..:...:||..::.|.      .:.|.||:
Human   741 E--WKTHVSF-----LNEDPGPVRRTADFNKI------QDSSRNNS 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	22/75 (29%)
		ANK	<131..200	CDD:238125	17/66 (26%)
		ANK repeat	138..174	CDD:293786	10/40 (25%)
		ANK	178..329	CDD:238125	49/166 (30%)
		ANK repeat	179..229	CDD:293786	13/49 (27%)
		Ank_2	184..311	CDD:289560	37/142 (26%)
		ANK repeat	231..278	CDD:293786	14/47 (30%)
		ANK repeat	280..311	CDD:293786	10/45 (22%)
		Ion_trans	519..727	CDD:278921	53/232 (23%)
TRPV3	NP_001245134.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..112
		ANK repeat	168..201	CDD:293786	9/32 (28%)
		Ank_2	172..293	CDD:289560	37/141 (26%)
		ANK	213..361	CDD:238125	50/171 (29%)
		ANK repeat	214..245	CDD:293786	10/30 (33%)
		ANK 1	214..243		10/28 (36%)
		ANK repeat	261..293	CDD:293786	11/31 (35%)
		ANK 2	261..291		11/29 (38%)
		Ank_2	266..366	CDD:289560	33/104 (32%)
		ANK 3	340..369		14/30 (47%)
		Ion_trans	517..689	CDD:278921	51/204 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145084
Domainoid	1	1.000	75	1.000	Domainoid score	I9056
eggNOG	1	0.900	-	-		E1_KOG3676
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10582
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4284
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.840