DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nan and LOC105947301

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_017949519.2	Gene:	LOC105947301 / 105947301	-ID:	-	Length:	639	Species:	Xenopus tropicalis

Alignment Length:	651	Identity:	163/651 - (25%)
Similarity:	278/651 - (42%)	Gaps:	147/651 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 WDLNMRGAVGETILHLCLLNASSLHADLAKRLLKFYPKLILDIYMSDEYYGESVLHIAIVNEDPA 194
            :|..::||:||.:||:..|..::   ::...||..:|.||......|.|.||:.|||||||::..
Frog    45 FDPTIKGALGENVLHIAALYNNN---EILVELLDAFPFLINKPIECDAYKGETALHIAIVNQNAE 106

  Fly   195 MVKYLLDANADVQE-RCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACL 258
            ||:.|:...||::. |..|.|.           :|..:           |..|:|||..||||.:
Frog   107 MVRELIARKADMENARATGNFF-----------APRRK-----------GQHYYGEYVTSFAAYV 149

  Fly   259 SQEECFRLVLARGADPDFQDTNGNTVLHMLVIYEKIEMFDVGYEVGTNI-------HIKNIQN-- 314
            ..:|..:.::...|..:.||:.||||.|:||:::...|....|:....|       :::.|.|
Frog   150 GNQEILQTLVENEAPLETQDSQGNTVFHILVLHQNKSMACKMYDFLAAIIPKKQLSYLETITNND 214

  Fly   315 -LTPLTLAAKLGRVEMFFHVMSIEREIYWQLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVF 378
             :||..|||:.|.|:||.:.:...|......|.:....|.|..||:.::..      ||::.:..
Frog   215 GMTPFKLAAQQGDVQMFEYFIKKRRHTILSFGPLGSTLYDLTGIDSWDDRL------SVIDIICT 273

  Fly   379 GDKLEHLELLDGVVI-DLLKTKWDTFCKSRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDGA 442
            .:......||:...: :||..||..|    .||.|.:..::::  :::.||
Frog   274 SNNNAARNLLEITPLKELLHYKWTAF----GYKYFLLCTIFYI--MYTVIL-------------- 318

  Fly   443 NSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNL 507
                                     |:...|:.....||  |...:.......:|:|      ..
Frog   319 -------------------------TLCCLYRPIMHTFT--YQDGKGNTRKPLYEAY------QT 350

  Fly   508 ESDLAKLRIMAELLNFVGAILYLLVALREARFLGLKMFIENLMT-APSRVMFLFSCALMMTIPWL 571
            .:|.  ||:..|::..||.||.|:..:.:....|.|.|..|.:| .|..|:.|.....::.:..|
Frog   351 RNDY--LRLSGEIIVVVGGILCLVSEILQFVRKGTKHFFGNTVTGGPFHVILLLYACFIIAVVIL 413

  Fly   572 RVSCLTEIDDHVTVVIMLTTAPYF---LFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMG 633
            |...    .|..|:::.|.....:   ::|.|||:.:||..:||.:||:||||:|..:.:..::|
Frog   414 RFLS----SDGETIMMSLALISAWCNVIYFARGFRLLGPLCIMIQKMVLGDLLKFCILLIAVLIG 474

  Fly   634 FSQAFYIIFLTFDNPSSPEDQDAESNPMPS---------------PMESIVAMFLMSLTNFGDYY 683
            |:.||.:.|...:..:.|     ..|..|.               |:.:.:.|..|.|
Frog   475 FAAAFNVHFQAMNTTAVP-----SFNGFPDITFTLFQLMMGLDSLPLPANIVMPKMIL------- 527

  Fly   684 GAMVSTQHEYEAKILFFLFMVIVSVLLVNMLIAMMGNTYQKIAEIRNE-WQRQWARIVLVVERSV 747
                         :|:.::|....|||||:|||:|.:|:.::...|.. |:.|.|...:::|||:
Frog   528 -------------VLYIVYMFFGFVLLVNLLIALMTHTHFRVTNDRTTLWRAQVAATTIMLERSI 579

  Fly   748 P 748
            |
Frog   580 P 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	29/78 (37%)
		ANK	<131..200	CDD:238125	26/68 (38%)
		ANK repeat	138..174	CDD:293786	10/35 (29%)
		ANK	178..329	CDD:238125	51/161 (32%)
		ANK repeat	179..229	CDD:293786	17/50 (34%)
		Ank_2	184..311	CDD:289560	39/134 (29%)
		ANK repeat	231..278	CDD:293786	11/46 (24%)
		ANK repeat	280..311	CDD:293786	10/37 (27%)
		Ion_trans	519..727	CDD:278921	58/226 (26%)
LOC105947301	XP_017949519.2	TRPV	21..609	CDD:424068	163/651 (25%)
		ANK repeat	53..88	CDD:293786	10/37 (27%)
		ANK repeat	91..122	CDD:293786	14/30 (47%)
		ANK repeat	133..169	CDD:293786	11/46 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7950
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3481
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	1	1.000	-	-		FOG0001377
OrthoInspector	1	1.000	-	-		mtm9325
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X396
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060