DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nan and LOC100494817

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_017950396.2	Gene:	LOC100494817 / 100494817	-ID:	-	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	627	Identity:	157/627 - (25%)
Similarity:	260/627 - (41%)	Gaps:	165/627 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 GESVLHIAIVNEDPAMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGY 244
            |::.|||||.......|:.|:...|||..:..|.|...:|.                     .|.
Frog    10 GQTALHIAIERRCKDYVELLVQKGADVHAQAKGRFFQPKDE---------------------GGC 53

  Fly   245 VYWGEYPLSFAACLSQEECFRLV---LARGADPDFQDTNGNTVLHMLV-IYEKIE--------MF 297
            .|:||.|||.|||..|::....:   :...||...||:.||||||.|| |.:..|        |:
Frog    54 FYFGELPLSLAACTKQDDIVDYLTENVYNKADLCRQDSRGNTVLHALVAIADNTEETTTFVTKMY 118

  Fly   298 D----VGYEVGTNIHIKNIQN---LTPLTLAAKLGRVEMFFHVMSIE-------------REIYW 342
            |    ...::.....::.|.|   ::||.:||:||::::|.|::.:|             |:  |
Frog   119 DRLVVKCAKLNKECRLETILNNDKMSPLMMAAQLGKIDIFQHIIQLEIKDEEAQHLSRKFRD--W 181

  Fly   343 QLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVFGD--KLEHLELLDGVVIDLLKTKWDTFCK 405
            ..|.:..:.|.|..:||.  |.|    ||||..:|:..  |..|..|....:.:|||.||..|..
Frog   182 NYGPLHSSLYDLATLDTY--EDG----DSVLEILVYKSTAKNRHEMLAVEPINELLKEKWKKFGA 240

  Fly   406 SRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMT 470
            ..||..|  ||..||:.:|:.|
Frog   241 VFFYLSF--FAYLFLMIIFTLI------------------------------------------- 260

  Fly   471 TEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNLESDLAKLRIMAELLNFVGAILYLLVALR 535
                       .||.|.|            ..|.....:....||::.|::..:..|::|:..::
Frog   261 -----------SYYRPME------------GTPPYPYRTTTDHLRLVGEIIILLTGIVFLIGNMK 302

  Fly   536 EARFLGLKMF--IENLMT--APSRVMFLFSCALMMTIPWLRVSCLTEIDDHVTVVIMLTTAPYF- 595
            :   |.:|.:  :.:|.|  ....:.|::|..:::|    ....|..|:.::.|:::.....:.
Frog   303 D---LIMKKYPGVYSLFTDGCFQLLNFIYSVLVIIT----ATLYLAGIEAYLAVMVIALVLGWIN 360

  Fly   596 -LFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNP--------SSP 651
             |:|.||.|..|.:.||:.:::..||.||:.:||:|::|::.|...:.    ||        ...
Frog   361 ALYFTRGLKLTGMYSVMLQKVLFKDLFRFLLVYLLFMVGYASALVSLL----NPCTNEMICNDGQ 421

  Fly   652 EDQDAESNPMPSPMESIVAMFLMSLT---NFGDYYGAMVSTQHEYEAK--ILFFLFMVIVSVLLV 711
            |:.....||......:.:::.|...|   ..||   ..|.:..:|.|.  :|...:::|..|||:
Frog   422 ENCTVSENPSCQHSTTFISLLLNLFTLTIGMGD---LEVISHAKYPAVFIVLLVTYLIITFVLLL 483

  Fly   712 NMLIAMMGNTYQKIA-EIRNEWQRQWARIVLVVERSVPPAER 752
            |||||:||.|..::: |.:..||.|||..:|.:||.:|...|
Frog   484 NMLIALMGETVGEVSKESKQIWQLQWATTILDIERYLPACMR 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	11/28 (39%)
		ANK	<131..200	CDD:238125	7/19 (37%)
		ANK repeat	138..174	CDD:293786
		ANK	178..329	CDD:238125	49/167 (29%)
		ANK repeat	179..229	CDD:293786	14/48 (29%)
		Ank_2	184..311	CDD:289560	40/142 (28%)
		ANK repeat	231..278	CDD:293786	13/49 (27%)
		ANK repeat	280..311	CDD:293786	12/43 (28%)
		Ion_trans	519..727	CDD:278921	55/227 (24%)
LOC100494817	XP_017950396.2	ANK repeat	9..40	CDD:293786	11/29 (38%)
		TRPV	10..571	CDD:424068	157/627 (25%)
		ANK repeat	56..90	CDD:293786	11/33 (33%)
		ANK repeat	92..131	CDD:293786	12/38 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010