Protein Alignment nan and trpv4l

DIOPT Version :10

• Sequence 1: NP_001261833.1
• Gene: nan / 39571
• FlyBaseID: FBgn0036414
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: XP_017950397.2
• Gene: trpv4l / 100494662
• XenbaseID: XB-GENE-22066240
• Length: 1014
• Species: Xenopus tropicalis
• Alignment Length: 807
• Identity: 198/807 - (24%)
• Similarity: 324/807 - (40%)
• Gaps: 241/807 - (29%)

  Fly    57 TKVEPFLYNKGAGRYFP-ISKLV--LLRNRDRPRTRQLPEIRALENPDDDFNIHDYCPEVSEAEY 118
            |:|.|:...:|....:| |.||.  |.....|....:|.|:|.|     .|.:|:. .::::.|:
 Frog   295 TEVTPYDPRRGPYPDYPDIKKLKEHLFDIVSRGSAAELEELRLL-----PFLLHEK-KQLTDEEF 353

  Fly   119 ISNPTAYRFVCWDLNMRGAVGETILHLCLLNASSLHADLAKRLLKF------YPKLILDIYMSDE 177
            :.:.|               |:|.|...|::.::...|....|:..      .|:.|...::  :
 Frog   354 LEDST---------------GKTCLSKALMHLNNGKNDTIPILIYIATITINVPQFINSPFL--K 401

  Fly   178 YY-GESVLHIAIVNEDPAMVKYLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNY 241
            || |::.|||||.......|:.|:...|||..:..|.|...:|.
 Frog   402 YYDGQTALHIAIERRCKDYVELLVQNGADVHAQAKGRFFQPKDE--------------------- 445

  Fly   242 DGYVYWGEYPLSFAACLSQEECFRLV---LARGADPDFQDTNGNTVLHMLVIYEK---------I 294
            .||.|:||.|||.|||.:|.:....:   :...||...:|:.||||||.||....         .
 Frog   446 GGYFYFGELPLSLAACTNQPDIVDYLTENVYNKADLCRRDSRGNTVLHALVAIADNTPENTKFVT 510

  Fly   295 EMFDVGYEVGTNIHIK--------------NIQNLTPLTLAAKLGRVEMFFHVMSIE------RE 339
            ||:|       ::.||              |...::||.:||:||::::|.|::.:|      |.
 Frog   511 EMYD-------HLVIKCAKLNKESSLETVTNNDKMSPLMMAAQLGKIDIFQHIIQLEIKDEEARH 568

  Fly   340 IY-----WQLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVFGD--KLEHLELLDGVVIDLLK 397
            :.     |..|.:..:.|.|..:||.  |.|    ||||..:|:..  |..|..|....:.:|||
 Frog   569 LSRKFRDWTYGPVYSSLYDLTTLDTY--EDG----DSVLEILVYKSTAKNRHEMLAVEPINELLK 627

  Fly   398 TKWDTFCKSRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHL 462
            .||..|....||..|  ||..||:.:|:.:
 Frog   628 EKWKKFGAVLFYLSF--FAYLFLMIIFTLV----------------------------------- 655

  Fly   463 HSKRATMTTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNLESDLAKLRIMAELLNFVGAI 527
                               .||.|  :|..|.:                 ..|...:.|..||.|
 Frog   656 -------------------AYYRP--MEGTPPY-----------------PYRTTTDHLRLVGEI 682

  Fly   528 LYLLVALREARFLGLKMFIENLMTAPSR----------------VMFLFSCALMMTIPWLRVSCL 576
            :.|||        |:..||.|:.....:                :.|::|..:::|    .:..|
 Frog   683 VILLV--------GIVFFIANIKDLIMKKYPGVYSLFTEGCFQLLNFIYSVLVLLT----AILYL 735

  Fly   577 TEIDDHVTVVIMLTTAPYF--LFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAFY 639
            ..|:.::.|:::.....:.  |:|.||.|..|.:.||:.:::..||.||:.:||:|::|::.|..
 Frog   736 AGIEAYLAVMVIALVLGWINALYFTRGLKLTGMYSVMLQKVLFKDLFRFLLVYLLFMVGYASALV 800

  Fly   640 IIFLTFDNPSSPE--DQDAESN----PMPSPMESI----VAMFLMSLT-NFGDYYGAMVSTQHEY 693
            .:.    ||.:.|  ..|.:.|    ..||...|.    :.:.|.:|| ..||   ..|.:..:|
 Frog   801 SLL----NPCTNEMICNDGQENCTVPENPSCQHSTTFSRLLLNLFTLTIGMGD---LEVISHAKY 858

  Fly   694 EAK--ILFFLFMVIVSVLLVNMLIAMMGNTYQKIA-EIRNEWQRQWARIVLVVERSVPPAERLKN 755
            .|.  ||...:::|..|||:|||||:||.|..::: |.:..||.|||..:|.:||.:|.
 Frog   859 PAVFIILLVTYLIITFVLLLNMLIALMGETVGEVSKESKQIWQLQWATTILDIERYLPA------ 917

  Fly   756 FMQYSQSMSDGRRALVLRLNMTEEEKE 782
            ||:  ::...| .|:::.|...:|:.|
 Frog   918 FMR--KAFRSG-EAVIIGLKQNKEQDE 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	TRPV	131..748	CDD:454755	172/694 (25%)
		ANK repeat	138..174	CDD:293786	8/41 (20%)
		ANK repeat	179..229	CDD:293786	15/50 (30%)
		ANK repeat	231..278	CDD:293786	14/49 (29%)
		ANK repeat	280..311	CDD:293786	13/53 (25%)
trpv4l	XP_017950397.2	TRPV	281..968	CDD:454755	198/807 (25%)
		ANK repeat	359..402	CDD:293786	8/44 (18%)
		ANK repeat	404..435	CDD:293786	11/30 (37%)
		ANK repeat	451..485	CDD:293786	11/33 (33%)
		ANK repeat	487..526	CDD:293786	13/45 (29%)