Protein Alignment nan and trpv4l.2

DIOPT Version :10

• Sequence 1: NP_001261833.1
• Gene: nan / 39571
• FlyBaseID: FBgn0036414
• Length: 834
• Species: Drosophila melanogaster
• Sequence 2: XP_012820642.2
• Gene: trpv4l.2 / 100494502
• XenbaseID: XB-GENE-22066247
• Length: 806
• Species: Xenopus tropicalis
• Alignment Length: 710
• Identity: 165/710 - (23%)
• Similarity: 265/710 - (37%)
• Gaps: 233/710 - (32%)

  Fly   139 GETILHLCLLNASSLHADLAKRLLKFYPKL-----ILDIYMSDEYY-GESVLHIAIVNEDPAMVK 197
            |:|.|...|:|......|....|:....|.     .:::..:|:|| |::.|||||.......|:
 Frog   125 GKTCLSKALMNLKDGKNDTIPVLIDIAEKTGNLQEFINLPFTDKYYNGQTALHIAIERRCKHYVE 189

  Fly   198 YLLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACLSQEE 262
            .|:...|||..:..|.|...:|.                     .||.|:||.|||.|||.:|.:
 Frog   190 LLVQKGADVHAQAKGCFFQPKDE---------------------GGYFYFGELPLSLAACTNQSD 233

  Fly   263 CFRLVLARG---ADPDFQDTNGNTVLHMLV----------------------------------- 289
            ....:....   ||...||:.||||||.||
 Frog   234 IVEYLTENAHNKADLCRQDSRGNTVLHALVAIADNSPENTIFVTEMYNHLVIKCAKLCAKRSLNG 298

  Fly   290 ------------IYEKIEMFDVGYEVGTNIHIKNIQNLTPLTLAAKLGRVEMFFHVMSIE----- 337
                        |.||.|...:.       .:.|.:|::||.:|||||::.:|.|:|.:|
 Frog   299 IPPLMMATKPGKIEEKQETLSLE-------AVLNKENMSPLMMAAKLGKIGIFQHIMQLEMKDEE 356

  Fly   338 --------REIYWQLGSITCAAYPLLMIDTINEETGNINKDSVLNFVVFGD--KLEHLELLDGVV 392
                    |:  |..|.:..:.|.|.|:            ||||..:|:..  |..|..|....:
 Frog   357 ALHLSRKFRD--WNYGPVYSSLYDLSML------------DSVLEILVYKSTAKNRHEMLAVEPI 407

  Fly   393 IDLLKTKWDTFCKSRFYKQFYMFALYFLISLFSFILRPGPDAKDEDEDGANSTTAKSDLYRQNGS 457
            .:||..||..|....||..|..:.:..:|.......||                       ..|:
 Frog   408 NELLSDKWKKFGAVSFYLSFIAYLIMMIIFTLIAYYRP-----------------------MKGT 449

  Fly   458 DSYHLHSKRATMTTEYKTFWLNFTEYYDPSEVEVLPAWWESYAQCPLMNLESDLAKLRIMAELLN 522
            ..|...:     ||::                                               |.
 Frog   450 PPYPYRT-----TTDH-----------------------------------------------LR 462

  Fly   523 FVGAILYLLVALREARFLGLKMFIENLMT------APSRVMFLFSCALMMTIPWLRVSCLTE--- 578
            .||.|:.||.        |:..||.|:..      ..:..:|...|..::.|.:..:..:|.
 Frog   463 LVGEIIILLT--------GIVFFISNMKNLFMKKYPGANSLFTDGCFQLLYIIYSVLVIITATLY 519

  Fly   579 ---IDDHVTVVIMLTTAPYF--LFFCRGFKTVGPFVVMIYRMVMGDLLRFVSIYLVFVMGFSQAF 638
               |:.::.|:::.....:.  |:|.||.|..|.:.:|:.:::..||.||:.:||:|::||:.|.
 Frog   520 LAGIEAYLAVMVIALVLGWINALYFTRGLKLTGMYSIMLQKILFKDLFRFLLVYLLFMVGFASAL 584

  Fly   639 YIIFLTFDNPSSPED--QDAESN----PMPSPMES------IVAMFLMSLTNFGDYYGAMVSTQH 691
            ..:.    ||.:.|:  .|.:.|    ..||...|      ::.:|.::: ..||.  .|:| ..
 Frog   585 VSLL----NPCTNEEICNDGQENCTVPENPSCQHSTTFSKLLLDLFTLAI-GMGDL--EMIS-HA 641

  Fly   692 EYEAK--ILFFLFMVIVSVLLVNMLIAMMGNTYQKIA-EIRNEWQRQWARIVLVVERSVP 748
            :|.|.  ||...:::|..:||:|||||:||.|..::: |.:..||.|||..:|.:|..:|
 Frog   642 KYPAVFIILLVTYLIITFILLLNMLIALMGGTVGEVSKESKQIWQLQWATTILDIENYLP 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	TRPV	131..748	CDD:454755	164/708 (23%)
		ANK repeat	138..174	CDD:293786	8/39 (21%)
		ANK repeat	179..229	CDD:293786	15/50 (30%)
		ANK repeat	231..278	CDD:293786	14/49 (29%)
		ANK repeat	280..311	CDD:293786	12/77 (16%)
trpv4l.2	XP_012820642.2	TRPV	50..763	CDD:454755	165/710 (23%)
		ANK repeat	124..167	CDD:293786	8/41 (20%)
		ANK repeat	171..202	CDD:293786	11/30 (37%)
		ANK repeat	218..252	CDD:293786	11/33 (33%)
		ANK repeat	254..293	CDD:293786	8/38 (21%)