DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nan and trpv3

DIOPT Version :9

Sequence 1:	NP_001261833.1	Gene:	nan / 39571	FlyBaseID:	FBgn0036414	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_031751640.1	Gene:	trpv3 / 100487056	XenbaseID:	XB-GENE-1013149	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	748	Identity:	190/748 - (25%)
Similarity:	328/748 - (43%)	Gaps:	172/748 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 KLVLLRNRDRPRTRQLPEIRALENPDDDFNIHDYCPEVSEAEYISNPT-AYRFVCWDLNMRGAVG 139
            |..|.||..:|..:.|  .:|:...|.:. :.|...|...:..:.:.| |..|....|..:. .|
Frog    93 KPALTRNTRKPTKKLL--FKAVSEGDTEM-LTDLLSEAKSSSRVYSVTQAKEFFMHKLTSKD-TG 153

  Fly   140 ETILHLCLLNASSLHADLAKRLLKFYPKL-ILDI-----YMSDEYYGESVLHIAIVNEDPAMVKY 198
            :|.|...|||.:....::.:.||.|..:. ||:.     |..:.|.|::.|:|||......:|||
Frog   154 KTCLMKALLNINEKTPEVVRSLLTFAEENDILETFINAEYTEENYKGQTALNIAIERRQVELVKY 218

  Fly   199 LLDANADVQERCCGAFMSAEDTKFSRTDSPDHEYVALCPMTNYDGYVYWGEYPLSFAACLSQEEC 263
            |::..|.:..|..|.|.:                    |...|:|: |:||.||:.|||.:|.|.
Frog   219 LIEKGAKIDVRAQGRFFN--------------------PKNKYEGF-YFGETPLALAACTNQPEI 262

  Fly   264 FRLVLARGAD-PDFQDTNGNTVLHMLV-IYEKIE--------MFDVGYEVGTNIHIKNIQN---L 315
            .:|::.:... ...||:.||||||.|| :.:..|        |:|.......|..::.|.|   |
Frog   263 VQLIMDKSPTIGTIQDSLGNTVLHALVNVADNSEAQNDFIIGMYDTILRNCKNKSLEQIPNNEGL 327

  Fly   316 TPLTLAAKLGRVEMFFHVMSIEREIY-------------WQLGSITCAAYPLLMIDTINEETGNI 367
            |.:.||||||:.|:..:::|  |||.             |..|.::.:.|.|..|||       .
Frog   328 TSMQLAAKLGKTEILHYILS--REIKEKENMVLSRKFTDWAYGPVSSSLYDLTSIDT-------C 383

  Fly   368 NKDSVLNFVVFGDKLEH------LELLDGVVIDLLKTKWDTFCKSRFYKQFYMFALYFLISLFSF 426
            ..:|||..||:...:::      ||.|.    .||:.||..|.:       |||.|.||:|.
Frog   384 WPNSVLEIVVYNTDIDNRHELLTLEPLH----TLLQMKWKKFAR-------YMFFLSFLLSF--- 434

  Fly   427 ILRPGPDAKDEDEDGANSTTAKSDLYRQNGSDSYHLHSKRATMTTEYKTFWLNFTEYYDP-SEVE 490
                                            :|::.              |....||.| .|.:
Frog   435 --------------------------------TYNIA--------------LTLVSYYRPRGEQD 453

  Fly   491 VLPAWWESYAQCPLMNLESDLAKLRIMAELLNFVGAILYLLVALREARFLGLKMFIENLMT-APS 554
            |.|           :||..:...|:::.::...|.| .||:|......||..:..:::::: |..
Frog   454 VYP-----------LNLSYENGWLQLVGQMFIIVCA-TYLMVKEAVVMFLVKQSDLKSVLSDAWF 506

  Fly   555 RVMFLFSCALMMTIPWLRVSC-LTEIDDHVTVVIMLTTAPY--FLFFCRGFKTVGPFVVMIYRMV 616
            .::|.....|::    :.|.| |..:|.::..:::.....:  .|::.|||:::|.:.|||.:::
Frog   507 HILFFIQAVLVI----VSVFCYLFGVDFYLVFLVLAMALGWMNLLYYTRGFQSLGIYSVMIQKVI 567

  Fly   617 MGDLLRFVSIYLVFVMGFSQAFYIIFLTFDNPSSPEDQDAESNPMPSPMESIVAMFLMSLTNFGD 681
            :.|:|:|:.:|::|::||..|...:   .:|....|:..:.|.       :|:.:|.:::    .
Frog   568 LNDVLKFLFVYILFLLGFGVALASL---LENCEDGEECQSLST-------AILELFELTI----G 618

  Fly   682 YYGAMVSTQHEYEAKILFFL--FMVIVSVLLVNMLIAMMGNTYQKIA-EIRNEWQRQWARIVLVV 743
            ..|..:....:|....||.|  |:::..|||:|||||:||.|.:||: |..:.|:.|.||.:|..
Frog   619 LRGLEMDKDPKYPVLFLFLLITFVILTFVLLLNMLIALMGETVEKISQESEHIWRLQRARTILEF 683

  Fly   744 ERSVPPAERLKNFMQYSQSMSDG-RRALVLRLN 775
            |:|:|...:.:..:..|.::|.| ...:.||:|
Frog   684 EKSLPAWLQARFQLGESCTVSKGDNNRICLRIN 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nan	NP_001261833.1	Ank_2	<131..209	CDD:289560	24/83 (29%)
		ANK	<131..200	CDD:238125	22/74 (30%)
		ANK repeat	138..174	CDD:293786	11/41 (27%)
		ANK	178..329	CDD:238125	52/163 (32%)
		ANK repeat	179..229	CDD:293786	13/49 (27%)
		Ank_2	184..311	CDD:289560	40/136 (29%)
		ANK repeat	231..278	CDD:293786	14/47 (30%)
		ANK repeat	280..311	CDD:293786	12/39 (31%)
		Ion_trans	519..727	CDD:278921	54/214 (25%)
trpv3	XP_031751640.1	TRPV3	58..736	CDD:411978	190/748 (25%)
		ANK repeat	108..151	CDD:293786	9/45 (20%)
		ANK repeat	153..197	CDD:293786	12/43 (28%)
		ANK repeat	200..230	CDD:293786	10/29 (34%)
		ANK repeat	246..278	CDD:293786	10/31 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I7950
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386733at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9325
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4284
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040