DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and SOX12

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_008874.2	Gene:	SOX12 / 6666	HGNCID:	11198	Length:	315	Species:	Homo sapiens

Alignment Length:	133	Identity:	69/133 - (51%)
Similarity:	86/133 - (64%)	Gaps:	16/133 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 ATSPG----QEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFID 193
            |..||    ..||||||||||||||:.:||:|....|.|||:|||||||..|:||.:|||.||:.
Human    27 AREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVR 91

  Fly   194 EAKRLRALHMKEHPDYKYRPRRKPKN-PLTAGPQ------GGLQMQAG----GMGQQKLGAGP-G 246
            ||:|||..||.::||||||||:|.|. |..|.|:      ||.:::.|    |.|.::...|| |
Human    92 EAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGSGGGSRLKPGPQLPGRGGRRAAGGPLG 156

  Fly   247 AGA 249
            .||
Human   157 GGA 159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	46/70 (66%)
SOX12	NP_008874.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		4/12 (33%)
		SOX-TCF_HMG-box	39..110	CDD:238684	46/70 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..288		25/60 (42%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250\|UniProtKB:Q04890	283..315
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.890