DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and SOX11

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_003099.1	Gene:	SOX11 / 6664	HGNCID:	11191	Length:	441	Species:	Homo sapiens

Alignment Length:	402	Identity:	113/402 - (28%)
Similarity:	150/402 - (37%)	Gaps:	162/402 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 IGSAGSLGSQSSLGSNGSGLNSSSGHQSAGMHSLATSP------------GQEGHIKRPMNAFMV 151
            :..|.||.::|:|..  ..|::..|      ..:|.||            ...||||||||||||
Human     2 VQQAESLEAESNLPR--EALDTEEG------EFMACSPVALDESDPDWCKTASGHIKRPMNAFMV 58

  Fly   152 WSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHMKEHPDYKYRPRRK 216
            ||:::||:|.:.:|.|||:|||||||..||:|.:|||.|||.||:|||..||.::||||||||:|
Human    59 WSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKK 123

  Fly   217 PKNPLTAGPQ-----------GGLQMQAGGMG---------------------QQKLGAGPGAGA 249
            ||...:|.|.           ||.....||.|                     ..|.|||..|.:
Human   124 PKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKKCGKLKAPAAAGAKAGAGKAAQS 188

  Fly   250 GGYNPFHQLPPYFAPSHHLDQGYPVPYFGGFDPLALSKLHQSQAAAAAA---------------- 298
            |.|.                        |..|...|..|..|.:....|
Human   189 GDYG------------------------GAGDDYVLGSLRVSGSGGGGAGKTVKCVFLDEDDDDD 229

  Fly   299 ---------VNNQGQQQ-------------GQAPPQL-----------PPTSLSSFYS------- 323
                     :..:..::             ||.|.||           .||..||..|
Human   230 DDDDELQLQIKQEPDEEDEEPPHQQLLQPPGQQPSQLLRRYNVAKVPASPTLSSSAESPEGASLY 294

  Fly   324 -----GIYSG---------------------ISAPSLYAAHSANAAGLYPSSSTSSPGSSPGTIT 362
                 |..||                     ::.|:|..|.|.:.:    :||:||.|||.|:..
Human   295 DEVRAGATSGAGGGSRLYYSFKNITKQHPPPLAQPALSPASSRSVS----TSSSSSSGSSSGSSG 355

  Fly   363 PNGMDGSMDSAL 374
            .:..|...|.:|
Human   356 EDADDLMFDLSL 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	47/70 (67%)
SOX11	NP_003099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		6/20 (30%)
		SOX-TCF_HMG-box	48..119	CDD:238684	47/70 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..216		29/123 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..292		10/51 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	319..359		12/43 (28%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250\|UniProtKB:Q7M6Y2	409..441
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910