DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and SOX9

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_000337.1	Gene:	SOX9 / 6662	HGNCID:	11204	Length:	509	Species:	Homo sapiens

Alignment Length:	551	Identity:	135/551 - (24%)
Similarity:	175/551 - (31%)	Gaps:	244/551 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QAQGLEDYAPQSQLQLSPGMDMDIKRVLHYSQSLAAMGGSPNGPAGQGVN-------------GS 67
            |.:||.. ||      ||.|..|             ..||| .|:|.|.:             |.
Human    14 QEKGLSG-AP------SPTMSED-------------SAGSP-CPSGSGSDTENTRPQENTFPKGE 57

  Fly    68 SGMGHHMSSHMTPHHMHQAVSA-----QQTLSPNSSIGSAGSLGSQSSLGSNGSGLNSSSGHQSA 127
            ..:.........|..:.:|||.     ..||.|             ..:..|||..|
Human    58 PDLKKESEEDKFPVCIREAVSQVLKGYDWTLVP-------------MPVRVNGSSKN-------- 101

  Fly   128 GMHSLATSPGQEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFI 192
                       :.|:||||||||||::..||::|...|.:||:|:||.||..|:||.|||||||:
Human   102 -----------KPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFV 155

  Fly   193 DEAKRLRALHMKEHPDYKYRPRRKPK-------------------NPLTAGPQGGLQMQAGGM-- 236
            :||:|||..|.|:||||||:|||:..                   |.:....|......:.||
Human   156 EEAERLRVQHKKDHPDYKYQPRRRKSVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSE 220

  Fly   237 --------GQQ----------KLGAGPGAG----------AGGYNP------------------- 254
                    ||.          |....||..          .||..|
Human   221 VHSPGEHSGQSQGPPTPPTTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISN 285

  Fly   255 -----FHQLPPYFAPSHHLDQGYP-----VPYFGGF-------DPLALSKLHQS----------- 291
                 .::...|..|:.|  .|.|     |.|.|.:       .|.:...:..|
Human   286 IETFDVNEFDQYLPPNGH--PGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQ 348

  Fly   292 --QAAAAAAVNNQGQ----QQGQAPPQLPP----TSLS------------------SFYSG---- 324
              ||..|.....|.|    ||..||||.|.    |:||                  |.||.
Human   349 PPQAPPAPQAPPQPQAAPPQQPAAPPQQPQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQH 413

  Fly   325 -----IYSGISAP----------------------SLYAAHSA-NAAGLY--------------- 346
                 .||..:.|                      |.|.:|:| ...|||
Human   414 SPQQIAYSPFNLPHYSPSYPPITRSQYDYTDHQNSSSYYSHAAGQGTGLYSTFTYMNPAQRPMYT 478

  Fly   347 PSSSTSSPGSSPGTITPNGMDGSMDSALRRP 377
            |.:.||...|.|.|.:|...:..:.:.|.||
Human   479 PIADTSGVPSIPQTHSPQHWEQPVYTQLTRP 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	44/70 (63%)
SOX9	NP_000337.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		16/73 (22%)
		Sox_N	22..94	CDD:403592	19/104 (18%)
		Dimerization (DIM). /evidence=ECO:0000305\|PubMed:31194875	63..103		11/71 (15%)
		PQA. /evidence=ECO:0000305\|PubMed:31194875	63..103		11/71 (15%)
		SOX-TCF_HMG-box	104..174	CDD:238684	43/69 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..273		26/112 (23%)
		Transactivation domain (TAM). /evidence=ECO:0000269\|PubMed:31194875	224..307		12/84 (14%)
		9aaTAD 1. /evidence=ECO:0000269\|PubMed:31194875	275..284		0/8 (0%)
		9aaTAD 2. /evidence=ECO:0000269\|PubMed:31194875	290..298		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..415		19/84 (23%)
		Transactivation domain (TAC). /evidence=ECO:0000269\|PubMed:8640233	394..509		21/114 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..509		8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810