DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and SOX4

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_003098.1	Gene:	SOX4 / 6659	HGNCID:	11200	Length:	474	Species:	Homo sapiens

Alignment Length:	305	Identity:	109/305 - (35%)
Similarity:	147/305 - (48%)	Gaps:	61/305 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 QQTLSPNSSIGSAGSLGSQSSLGSNGSGL-----NSSSGHQSAGMHSLATSPG----QEGHIKRP 145
            |||   |::..:...|..:||  .:|:||     :|.:...:|.....|..|.    ..||||||
Human     3 QQT---NNAENTEALLAGESS--DSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIKRP 62

  Fly   146 MNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHMKEHPDYK 210
            ||||||||:::||:|.:.:|.|||:|||||||..||||.:|:|.|||.||:|||..||.::||||
Human    63 MNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIREAERLRLKHMADYPDYK 127

  Fly   211 YRPRRK-------------------PKNPLTAGPQGGLQMQAGGMGQQKL-GAGPGAGAGGYNPF 255
            ||||:|                   .|.....|..||.....||.|.... |.|.||..||.|.
Human   128 YRPRKKVKSGNANSSSSAAASSKPGEKGDKVGGSGGGGHGGGGGGGSSNAGGGGGGASGGGANS- 191

  Fly   256 HQLPPYFAPSHHLDQGYPVPYFGGFDPLALSKLHQ----------SQAAAAAAVNNQGQQQGQAP 310
                   .|:.....|..|.  ||... .:||.|.          .:||||||.:...:|.|.|
Human   192 -------KPAQKKSCGSKVA--GGAGG-GVSKPHAKLILAGGGGGGKAAAAAAASFAAEQAGAA- 245

  Fly   311 PQLPPTSLSSFYSGIYSGISAPSLYAAHSANAAGLYPSSSTSSPG 355
             .|.|...::.:..:|.. ..||..|:.|:.|:.   |::.::||
Human   246 -ALLPLGAAADHHSLYKA-RTPSASASASSAASA---SAALAAPG 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	47/70 (67%)
SOX4	NP_003098.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		14/59 (24%)
		SOX-TCF_HMG-box	58..129	CDD:238684	47/70 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..228		27/110 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..286		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..416
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1275
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860