Protein Alignment D and SOX17

DIOPT Version :9

• Sequence 1: NP_001261830.1
• Gene: D / 39570
• FlyBaseID: FBgn0000411
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_071899.1
• Gene: SOX17 / 64321
• HGNCID: 18122
• Length: 414
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 104/326 - (31%)
• Similarity: 146/326 - (44%)
• Gaps: 80/326 - (24%)

  Fly    94 SPNSSIGSAGSLGSQSSLGSNGSGLN--------------SSSGHQSAGMHSLATSPGQ---EGH 141
            ||::...|.....:||:|.:..:||.              ...|...|...:.|.:.|:   |..
Human     3 SPDAGYASDDQSQTQSALPAVMAGLGPCPWAESLSPIGDMKVKGEAPANSGAPAGAAGRAKGESR 67

  Fly   142 IKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHMKEH 206
            |:|||||||||::.:|:::|:.||.:||:|:||.||..||.|..:|||||::||:|||..||::|
Human    68 IRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDH 132

  Fly   207 PDYKYRPRRKPK----------------NPLTA--GPQGGLQMQAGGMG----QQKLGAGPGAGA 249
            |:|||||||:.:                .|..|  ||:|| ::...|:|    :|...|||
Human   133 PNYKYRPRRRKQVKRLKRVEGGFLHGLAEPQAAALGPEGG-RVAMDGLGLQFPEQGFPAGP---- 192

  Fly   250 GGYNPFHQLPPYFAPSHHLD---------QGYPVPY-----FGGFDP-LALSKLHQSQAAAAAAV 299
                |.  |||:.. .|:.|         .|||:|.     ..|.|| .|...........||..
Human   193 ----PL--LPPHMG-GHYRDCQSLGAPPLDGYPLPTPDTSPLDGVDPDPAFFAAPMPGDCPAAGT 250

  Fly   300 NNQGQQQGQA-PPQLPPTSLSSFYSGIYSGISAPSLYAAHSA-----NAAGLYPSSSTSSPGSSP 358
            .:..|....| ||:.|...:........:|.|.|.|.|..||     .|.|        |||:..
Human   251 YSYAQVSDYAGPPEPPAGPMHPRLGPEPAGPSIPGLLAPPSALHVYYGAMG--------SPGAGG 307

  Fly   359 G 359
            |
Human   308 G 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	40/70 (57%)
SOX17	NP_071899.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		6/18 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..66		4/29 (14%)
		SOX-TCF_HMG-box	67..138	CDD:238684	40/70 (57%)
		Sox_C_TAD	201..412	CDD:288887	30/116 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..286		7/29 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..352		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940