DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D and sox12

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001025449.1	Gene:	sox12 / 562381	ZFINID:	ZDB-GENE-040724-33	Length:	355	Species:	Danio rerio

Alignment Length:	252	Identity:	92/252 - (36%)
Similarity:	124/252 - (49%)	Gaps:	45/252 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 GHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHMK 204
            ||||||||||||||:::||:|.:..|.|||:|||||||..||||.:.||.|||.||:|||..||.
Zfish    51 GHIKRPMNAFMVWSQIERRKIMEQWPDMHNAEISKRLGKRWKLLPDYEKIPFIKEAERLRLKHMA 115

  Fly   205 EHPDYKYRPRRKPK--NPLTAGPQGGLQM--------QAGGMGQQKLGAGPGAGAG----GYNPF 255
            ::||||||||:|.|  .|:..|.:  |.|        ::.|:..:.|...|.:...    ..|.:
Zfish   116 DYPDYKYRPRKKSKGSTPVKLGEK--LPMKSSKPLPGRSSGLSCKGLKIKPASSKHKMNFSSNKY 178

  Fly   256 HQLPPYFAPSHHLDQGYPVPYFGGFDPLALSK--LHQSQAAAAAAVNNQGQQQGQAP-PQL---P 314
            .......:....:|.....|.....|....|.  |||.     |.|.::.||    | |:|   .
Zfish   179 KSYSESMSDDDTMDVNLESPVTQQDDRNTSSHFVLHQQ-----ATVQSEDQQ----PIPELRVKV 234

  Fly   315 PTSLSSFYSGIYSGISAPSLYAAHSANAAGLYPSSSTSSP-GSSPG-TITPNGMDGS 369
            |.|.:|            |:.:..|.:....:|.|:||.| ||:.| :.||.....|
Zfish   235 PISQTS------------SIQSLSSDSECQAFPESTTSEPRGSTSGRSSTPTSTSSS 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	47/70 (67%)
sox12	NP_001025449.1	SOX-TCF_HMG-box	52..123	CDD:238684	47/70 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.940