Protein Alignment D and SOX18

DIOPT Version :9

• Sequence 1: NP_001261830.1
• Gene: D / 39570
• FlyBaseID: FBgn0000411
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_060889.1
• Gene: SOX18 / 54345
• HGNCID: 11194
• Length: 384
• Species: Homo sapiens
• Alignment Length: 254
• Identity: 88/254 - (34%)
• Similarity: 124/254 - (48%)
• Gaps: 45/254 - (17%)

  Fly   139 EGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALHM 203
            |..|:|||||||||::.:|:::|:.||.:||:.:||.||..||.|..:|||||::||:|||..|:
Human    82 ESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNAAEKRPFVEEAERLRVQHL 146

  Fly   204 KEHPDYKYRPRRKPKNPLTAGPQGGLQMQAGGMGQQKLGAGP-GAGAGGYNPFHQLPPYFAPSHH 267
            ::||:||||||||.:.......:.||.:.  |:...:....| .|.:|....|.:|||..|....
Human   147 RDHPNYKYRPRRKKQARKARRLEPGLLLP--GLAPPQPPPEPFPAASGSARAFRELPPLGAEFDG 209

  Fly   268 LDQGYPVPYFGGFDPLALSKLHQSQAAAAAAVNNQGQQQGQA----PPQLP-------------P 315
            |  |.|.|.....|                     |.:.|:|    ||..|             |
Human   210 L--GLPTPERSPLD---------------------GLEPGEAAFFPPPAAPEDCALRPFRAPYAP 251

  Fly   316 TSLSSFYSGIYSGISAPSLYAA-HSANAAGLYPSSSTSSPGSSPGTITPNGMDGSMDSA 373
            |.||....|.|....|.:|..| .:|..|||| ..:..:||..||.::|......::||
Human   252 TELSRDPGGCYGAPLAEALRTAPPAAPLAGLY-YGTLGTPGPYPGPLSPPPEAPPLESA 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	38/70 (54%)
SOX18	NP_060889.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..88		2/5 (40%)
		SOX-TCF_HMG-box	84..155	CDD:238684	38/70 (54%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:P43680	87..100		9/12 (75%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:P43680	111..123		6/11 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..218		25/75 (33%)
		Important for transcriptional activation. /evidence=ECO:0000250|UniProtKB:P43680	166..231		19/89 (21%)
		Sox_C_TAD	193..382	CDD:288887	37/141 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..312		5/17 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940