DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment D and sox17a

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_989425.1	Gene:	sox17a / 395066	XenbaseID:	XB-GENE-484295	Length:	383	Species:	Xenopus tropicalis

Alignment Length:	311	Identity:	90/311 - (28%)
Similarity:	131/311 - (42%)	Gaps:	107/311 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 LGSNGSG-LNSSSGHQSAGMHSLATSPGQ-EGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEIS 173
            :.|.|.| |.|.:|.        |.|.|: |..|:|||||||||::.:|:::|:.||.:||:|:|
Frog    36 MNSLGEGKLKSDAGS--------ANSRGKAEARIRRPMNAFMVWAKDERKRLAQQNPDLHNAELS 92

  Fly   174 KRLGAEWKLLAESEKRPFIDEAKRLRALHMKEHPDYKYRPRRK------------------PKNP 220
            |.||..||.|..:|||||::||:|||..||::||:|||||||:                  |...
Frog    93 KMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRADTGFMHMAEPPES 157

  Fly   221 LTAGPQGGLQMQAGGMGQQKLGAGPGAGAGGYN----PFHQLPPYFAPSHHLDQGYPVPYFGGF- 280
            ...|..|.:.:::..:              ||:    |..|||   ..||:.:.....|::.|:
Frog   158 AVLGTDGRMCLESFSL--------------GYHEQTYPHSQLP---QGSHYREPQAMAPHYDGYS 205

  Fly   281 ------DPLAL-------------------------SKLHQSQAAAAAAVNN--QGQQQGQAPPQ 312
                  .||.|                         |..||..:.|:..|..  |.:|.||..|
Frog   206 LPTPESSPLDLAEADPVFFTSPPQDECQMMPYSYNASYTHQQNSGASMLVRQMPQAEQMGQGSP- 269

  Fly   313 LPPTSLSSFYSGIYSGISAPSLY---------AAHSANAAGLYPSSSTSSP 354
                     ..|:....|:|.:|         |.|..     .|.:..:||
Frog   270 ---------VQGMMGCQSSPQMYYGQMYLPGSARHHQ-----LPQAGQNSP 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	40/70 (57%)
sox17a	NP_989425.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..58		9/28 (32%)
		SOX-TCF_HMG-box	60..131	CDD:238684	40/70 (57%)
		Sox17_18_mid	191..239	CDD:371880	5/47 (11%)
		Required for transcriptional activity and interaction with ctnnb1. /evidence=ECO:0000250\|UniProtKB:Q3KQ35	332..337
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040