DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and SOX8

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_055402.2	Gene:	SOX8 / 30812	HGNCID:	11203	Length:	446	Species:	Homo sapiens

Alignment Length:	443	Identity:	117/443 - (26%)
Similarity:	155/443 - (34%)	Gaps:	152/443 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GGSPNGPAGQGVNGSSGMGHHMSSHMTPHHMHQAVSAQQTLSPNSSIGSAGSLGSQSSLGSNGSG 117
            |....|.||..|.|:.|.....:....|..:..|||  |.|.     |...||......|..|..
Human    38 GSEGLGRAGVAVGGARGDPAEAADERFPACIRDAVS--QVLK-----GYDWSLVPMPVRGGGGGA 95

  Fly   118 LNSSSGHQSAGMHSLATSPGQEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKL 182
            |.:                  :.|:||||||||||::..||::|...|.:||:|:||.||..|:|
Human    96 LKA------------------KPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRL 142

  Fly   183 LAESEKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKNPLTAG-------------PQGGLQMQA- 233
            |:|||||||::||:|||..|.|:||||||:|||  :....||             |.||...:|
Human   143 LSESEKRPFVEEAERLRVQHKKDHPDYKYQPRR--RKSAKAGHSDSDSGAELGPHPGGGAVYKAE 205

  Fly   234 GGMGQ-------------------------QKLGAGPGAGAGGYNP------------------- 254
            .|:|.                         |:.||.|.....|..|
Human   206 AGLGDGHHHGDHTGQTHGPPTPPTTPKTELQQAGAKPELKLEGRRPVDSGRQNIDFSNVDISELS 270

  Fly   255 -----------FHQLPPYFAPSHHLDQGYPVP------YFGGFDPLALSKL--HQSQAAAAAAVN 300
                       .|:...|      |..|.|.|      |.|.:.....|.:  |:|..:|:|:..
Human   271 SEVMGTMDAFDVHEFDQY------LPLGGPAPPEPGQAYGGAYFHAGASPVWAHKSAPSASASPT 329

  Fly   301 NQG-----------------------------QQQGQAPPQLPPTSLSSFYSGIYSGISAPSLYA 336
            ..|                             ..|..|.|..|....:. ..|.|..:.|.|.|.
Human   330 ETGPPRPHIKTEQPSPGHYGDQPRGSPDYGSCSGQSSATPAAPAGPFAG-SQGDYGDLQASSYYG 393

  Fly   337 AHSANAAGLYPSSSTSSPGSSPGTITPNGM------------DGSMDSALRRP 377
            |:...|.|||......||.....:...||:            |..:.:.|.||
Human   394 AYPGYAPGLYQYPCFHSPRRPYASPLLNGLALPPAHSPTSHWDQPVYTTLTRP 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	44/70 (63%)
SOX8	NP_055402.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		7/19 (37%)
		Sox_N	18..89	CDD:315171	16/57 (28%)
		Dimerization (DIM). /evidence=ECO:0000303\|PubMed:31194875	58..100		12/66 (18%)
		SOX-TCF_HMG-box	101..171	CDD:238684	43/69 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..259		29/105 (28%)
		Transactivation domain (TAM). /evidence=ECO:0000303\|PubMed:31194875	224..298		12/79 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..378		9/59 (15%)
		Transactivation domain (TAC). /evidence=ECO:0000303\|PubMed:31194875	335..446		20/111 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..446		2/20 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810