DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and tcf7l1b

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_571371.2	Gene:	tcf7l1b / 30556	ZFINID:	ZDB-GENE-991110-10	Length:	550	Species:	Danio rerio

Alignment Length:	387	Identity:	95/387 - (24%)
Similarity:	143/387 - (36%)	Gaps:	109/387 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LEDYAPQSQLQLSPGMDMDIKRVL--------HYSQSLAAMGGSPNGPA-GQGVNGSSGMGHHMS 75
            |..|.|     ||||....|...|        .:...:.|.|.....|| ....:.||.:....|
Zfish   211 LSPYYP-----LSPGAVGQIPHPLGWLVPQQGQHMYPITAGGFRHPYPALAMNASMSSLVSSRFS 270

  Fly    76 SHMTPHHMHQAVSAQQTLSPNSSIGSAGSLGSQSSLGSNGSGLNSSSGHQSAGMHSLATSPG--- 137
            .|:.|||.|   ...||..|:.:|.|  .:..|...|.....:|:.             |||
Zfish   271 PHLVPHHPH---GLHQTGIPHPAIVS--PVIKQEPNGELSPPVNTK-------------SPGPNK 317

  Fly   138 ----QEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRL 198
                ::.|||:|:||||::.:..|.::..:.....::.|::.||..|..|:..|:..:.:.|::.
Zfish   318 KDEDKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKE 382

  Fly   199 RALHMKEHP------DYKYRPRRKPKNPLTAGPQGGLQMQAGG-----MGQQKLGAGPGAGAGGY 252
            |.||.:.:|      :|..|.:||..|...:.|: ...|::..     :.|:|:...||:..|..
Zfish   383 RQLHSQLYPGWSARDNYGKRKKRKRDNKTDSTPE-DFSMRSKKPCVQYLPQEKMIDSPGSSHGSM 446

  Fly   253 NPFHQLPPYFAPSHHLDQGYPVPYFGGFDPLALSKLHQSQAAAAAAVNNQGQQQGQAPPQLPPTS 317
                           ||           .|...|....|.||.||..:.|.|          |.|
Zfish   447 ---------------LD-----------SPATPSAALASPAAPAATHSEQAQ----------PLS 475

  Fly   318 LSSFYSGIYSGISAPSLYAAHSANAAGLYPSSSTSSPGSSPGTITPNGMDGSMDSALRRPVP 379
            |:          :.|..:...|...    ||||:||..||.|..||        ..|.||:|
Zfish   476 LT----------TKPERFPLLSKPP----PSSSSSSSSSSSGLPTP--------PLLSRPLP 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	21/76 (28%)
tcf7l1b	NP_571371.2	CTNNB1_binding	1..231	CDD:285538	9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..76
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..326		6/40 (15%)
		SOX-TCF_HMG-box	325..396	CDD:238684	20/70 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	58	1.000	Inparanoid score	I5417
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960