DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment D and tcf7l1a

DIOPT Version :9

Sequence 1:	NP_001261830.1	Gene:	D / 39570	FlyBaseID:	FBgn0000411	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_571344.1	Gene:	tcf7l1a / 30523	ZFINID:	ZDB-GENE-980605-30	Length:	560	Species:	Danio rerio

Alignment Length:	370	Identity:	94/370 - (25%)
Similarity:	135/370 - (36%)	Gaps:	75/370 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LEDYAPQSQLQLSPGMDMDIKRVLHYSQSLAAMGGS------PNG-----PA-GQGVNGSSGMGH 72
            |..|.|     ||||.   :.::.|....|....|.      |.|     || ....:.||.:..
Zfish   213 LSPYYP-----LSPGA---VGQIPHPLGWLVPQQGQHMYSIPPGGFRHPYPALAMNASMSSLVSS 269

  Fly    73 HMSSHMTPHHMHQAVSAQQTLSPNSSIGSAGSLGSQSSLGSNGSGLNSSSGHQSAGMHSLATSPG 137
            ..|.||.||..|   ...||..|:.:|.|...  .|...|.:.|  ||:.|..|.   .:.....
Zfish   270 RFSPHMVPHPPH---GLHQTGIPHPAIVSPAI--KQEPNGESPS--NSTHGKPSV---PVKKEEE 324

  Fly   138 QEGHIKRPMNAFMVWSRLQRRQIAKDNPKMHNSEISKRLGAEWKLLAESEKRPFIDEAKRLRALH 202
            ::.|||:|:||||::.:..|.::..:.....::.|::.||..|..|:..|:..:.:.|::.|.||
Zfish   325 KKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLH 389

  Fly   203 MKEHPDY----KYRPRRKPKNPLTAGPQGGLQMQAGGMGQQKLGAGPGAGAGGYNPFHQLPPYFA 263
            .:.:|.:    .|..|:|.|....:.                   .|........|..|..||.:
Zfish   390 SQLYPGWSARDNYGKRKKRKRDCKSD-------------------SPSESNFSPQPKKQCVPYLS 435

  Fly   264 PSHHLDQGYPVPYFGGF--DPLALSKLHQSQAAAAAAVNNQGQ-------QQGQAPPQLPPTSLS 319
            .....|.  |....|..  .|...|....|.||.||..:.|.|       .:|:|....|...|.
Zfish   436 SEKMCDS--PTSSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPEGRAHHNHPHFPLP 498

  Fly   320 SFYSGIYSGISAPSLYAAHSANAAGLYPSSSTSSPGSSPGTITPN 364
            ...||..||    |..|.||.:.    |...||.|   |..:.||
Zfish   499 GKSSGSGSG----SSMALHSLSR----PIPFTSLP---PSLLGPN 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
D	NP_001261830.1	SOX-TCF_HMG-box	141..212	CDD:238684	20/74 (27%)
tcf7l1a	NP_571344.1	CTNNB1_binding	1..233	CDD:285538	8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..328		7/37 (19%)
		SOX-TCF_HMG-box	328..399	CDD:238684	20/70 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..513		31/142 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	58	1.000	Inparanoid score	I5417
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960